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Effect of Corticotropin-Releasing Hormone ( CRH ) and CRH Receptor1 ( CRH-R1 ) Gene Variants in Human Endometrial Cancer

Research Project

Project/Area Number 23659120
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionTohoku University

Principal Investigator

SATO Naoko  東北大学, 医学(系)研究科(研究院), 助教 (40457750)

Co-Investigator(Kenkyū-buntansha) SUZUKI Takashi  東北大学, 大学院医学系研究科, 教授 (10261629)
小澤 信義  独立行政法人国立病院機構(仙台医療センター臨床研究部), その他部局等, その他 (30169289)
Research Collaborator FUKUDO Shin  東北大学, 大学院医学系研究科, 教授 (80199249)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsがん / ストレス / CRH / QOL / CRHR1 / CRHR2 / 生存率
Outline of Final Research Achievements

Corticotropin-releasing hormone (CRH), a major regulator of the stress response, regulates various biological functions through its interaction with CRH receptors 1
(CRHR1) and 2 (CRHR2). CRH, CRHR1, and CRHR2 have recently been reported in several types of carcinoma.In our study results, CRH, CRHR1, and CRHR2 immunoreactivitywas detected in the cytoplasm of endometrial carcinoma cells. And suggest that intratumoral CRH-CRHR1 signaling plays an important role in the progression of endometrial carcinoma and that CRHR1 is a potent prognostic factor in patients with this disease.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (12 results)

All 2015 2014 2013 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (9 results) Remarks (1 results)

  • [Journal Article] Immunolocalization of corticotropin-releasing hormone (CRH) and its receptors (CRHR1 and CRHR2) in human endometrial carcinoma: CRHR1 as a potent prognostic factor.2014

    • Author(s)
      Sato N, Takagi K, Suzuki T, Miki Y, Tanaka S, Nagase S, Warita H, Fukudo S, Sato F, Sasano H, Ito K.
    • Journal Title

      Int J Gynecol Cancer

      Volume: 24 Issue: 9 Pages: 1549-1557

    • DOI

      10.1097/igc.0000000000000269

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Corticotropin-releasing hormone receptor 1 gene variants in irritable bowel syndrome2012

    • Author(s)
      Sato N, Suzuki N, Sasaki A, Aizawa E, Obayashi T, Kanazawa M, Mizuno T, Kano M, Aoki M, Fukudo S
    • Journal Title

      PLoS One

      Volume: 7(9) Issue: 9 Pages: e42450-e42450

    • DOI

      10.1371/journal.pone.0042450

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 膵腫瘍患者の手術後6ヶ月までのQOLに関する縦断研究2015

    • Author(s)
      佐藤菜保子,佐藤冨美子,片寄友,中川圭,元井冬彦,川口圭,海野倫明
    • Organizer
      第29回日本がん看護学会学術集会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2015-02-28 – 2015-03-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Quality Of Life (QOL) Evaluation For Pancreatic Tumor Surgery Patients At The Three And Six Months After Surgery In A Single Center Prospective Study2014

    • Author(s)
      Katayose Y., Sato N., Motoi, F., Nakagawa K., Yoshida H.,Morikawa T., Hayashi H., Mizuma M., Fukase K., Aoki T, Kawaguchi K., Naitoh T, Unno M
    • Organizer
      The 45thAnniversary Meeting of APA & JPS
    • Place of Presentation
      Hawaii (America)
    • Year and Date
      2014-11-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] SF36v2を用いた術前化学療法前後のQOL評価2014

    • Author(s)
      川口 桂,片寄 友,佐藤 菜保子,岡田 良,益田 邦洋,石田 晶玄,藪内 伸一,深瀬 耕二,大塚 英郎,水間 正道,坂田 直昭,中川 圭,岡田 恭穂,森川 孝則,林 洋毅,吉田 寛,元井 冬彦,海野 倫明
    • Organizer
      第9回膵癌術前治療研究会
    • Place of Presentation
      鹿児島県医師会館(鹿児島市)
    • Year and Date
      2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] SF36v2を用いた膵頭十二指腸切除術後のQOL評価2014

    • Author(s)
      川口桂,片寄友,佐藤菜保子,元井冬彦,海野倫明
    • Organizer
      第168回東北外科集談会・第83回日本小児外科学会東北地方会・第26回日本血管外科学会東北地方会
    • Place of Presentation
      秋田県総合保健センター(秋田市)
    • Year and Date
      2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 膵腫瘍患者の手術後3ヶ月時点のQOLとFACT-Hep 症状項目との関連2014

    • Author(s)
      佐藤菜保子, 片寄友, 元井冬彦, 中川圭, 吉田寛, 森川孝則, 川口桂, 薮内伸一,工藤克昌, 佐藤昌美, 佐藤冨美子, 海野倫明
    • Organizer
      第52回日本癌治療学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 健康関連QOL尺度SF36v2による膵腫瘍手術の術後3ヶ月評価:初期54例からの検討2014

    • Author(s)
      片寄友, 佐藤菜保子, 元井冬彦, 中川圭, 吉田寛, 森川孝則, 岡田恭穂, 林洋毅, 坂田直昭, 水間正道, 深瀬耕二, 青木豪, 薮内伸一, 川口桂, 江川新一, 内藤剛, 海野倫明
    • Organizer
      第45回日本膵臓学会大会
    • Place of Presentation
      北九州国際会議場(北九州市)
    • Year and Date
      2014-07-11 – 2014-07-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒト子宮内膜癌におけるCRH発現と予後の関連2013

    • Author(s)
      佐藤菜保子,高木清司,鈴木貴,三木康宏,割田仁,福土審,佐藤冨美子,八重樫伸夫,伊藤潔
    • Organizer
      第51回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] 過敏性腸症候群における副腎皮質刺激ホルモン放出ホルモン関連遺伝子

    • Author(s)
      佐々木彩加,佐藤菜保子,鈴木直輝,金澤素,青木正志,福土審
    • Organizer
      第76 回日本心身医学会東北地方会
    • Place of Presentation
      仙台
    • Related Report
      2012 Research-status Report
  • [Presentation] 過敏性腸症候群におけるコルチコトロピン放出ホルモン関連遺伝子多型

    • Author(s)
      佐々木彩加,佐藤菜保子,鈴木直輝,金澤素,青木正志,福土審
    • Organizer
      第3回Japan Gut Forum
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Remarks] 東北大学大学院医学系研究科 がん看護学分野 ホームページ

    • URL

      http://www.oncolnurs.med.tohoku.ac.jp/achievements.html

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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