| Project/Area Number |
23659122
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUJITA Hirofumi 岡山大学, 大学院・医歯薬学総合研究科, 助教 (20423288)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ミトコンドリア / 機能性化合物 / エネルギー代謝 / 酸化ストレス / 筋管細胞 / 機能性分子 / 活性酸素 / 転写因子 / 酸化還元レベル / 生体成分 / 低分子化合物 / 酸化還元制御 / アミノレブリン酸 |
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| Research Abstract |
The decrease of the mitochondrial quantity and function is associated with the onset of the various disease including life-style related diseases. Therefore, that the compound to make increase mitochondrial quantity contributes to treatment and prevention of the mitochondrial associated diseases is expected. In this study, we found that several kinds of compounds increased mitochondrial quantity in murine skeletal muscle cells. Also, cells treated with a compound got resistance against the oxidative stress, and the compounds were found to increase the cellular functions. These compounds are promising to practical use in the therapies aimed at enhancement of mitochondrial quantity and functions.
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