| Project/Area Number |
23659136
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Mie University |
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Principal Investigator |
TANAKA Toshio 三重大学, 大学院・医学系研究科, 教授 (00135443)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIMURA Yuuhei 三重大学, 大学院・医学系研究科, 講師 (30303720)
SHIMADA Yasuhito 三重大学, 大学院・医学系研究科, 助教 (40378427)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 創薬・ゲノム薬理学 / 肥満モデル / オミックス / 治療遺伝子 / トランスクリプトーム / 疾患モデル |
|---|
| Research Abstract |
We found new candidate genes for obesity treatment using DNA microarray experiments and pathway analyses with zebrafish model of diet-induced obesity. Gene knockdown studies of these candidates using morpholino antisense oligonucleotides revealed that several genes including mxd3 could ameliorated the disease phenotypes in model animals. In addition, we clarify the mechanism of these therapeutic effects by Omics research approach.
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