| Project/Area Number |
23659138
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General pharmacology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Fumi 九州大学, 大学院・医学研究院, 教授 (50274436)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 新規抗炎症薬 / mPGES-1 / 抗炎症薬 / 炎症 / がん |
|---|
| Research Abstract |
We previously found that DIF, synthesized by Dictyostelium discoideum, inhibited the expression of microsomal PGES-1 (mPGES-1).In this study, we tried to identify a new inhibitor of mPGES-1 by natural products library screening and found that niclosamide was more effective than DIF-1. Subsequently, we examined the changes of the gene expression profile induced by DIF-1, DIF-3 and niclosamide using DNA microarray chips. There were several genes affected by all these three compounds, whereas none of them did not seem to be related with inflammation
|
