| Project/Area Number |
23659147
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松本 絵里子 千葉大学, 医学(系)研究科(研究院), 技術職員 (20422256)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUMOTO Eriko 千葉大学, 大学院・医学研究院, 技術職員 (20422256)
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| Research Collaborator |
IWASE Katsuro 千葉大学, 大学院・医学研究院, 講師 (80322030)
OOHIRA Ayano 千葉大学, 大学院・医学研究院, 技術補佐員
ARITA Emiko 千葉大学, 大学院・医学研究院, 技術補佐員
TAIRA Akiko 千葉大学, 大学院・医学研究院, 博士課程大学院生
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 生体分子医学 / 生物時計 / 時間生物学 / 糖新生 / オルニチンサイクル / グルカゴン / 日周リズム / 概日リズム / 遺伝子発現 / 代謝調節 |
|---|
| Research Abstract |
In the liver of nocturnal mice fed on the standard diet, the gluconeogenic pathway, which synthesizes glucose from amino acids, is activated during the resting-fasting phase i.e. the light period. Here, we showed that in the liver of mice fed on high protein diets, compared to the standard diet, mRNA levels of gluconeogenic enzymes were increased during the acting-feeding phase i.e. the dark period. While corticosterone levels in the plasma showed no apparent change, glucagon increased prominently during the feeding phase of high protein diets, and was regarded as a candidate for the humoral factor that mediates the activation of gluconeogenic enzyme genes in response to dietary amino acids.
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