| Project/Area Number |
23659154
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 分泌タンパク質 / シグナルペプチド / 非古典的分泌経路 / ナルディライジン / タンパク質分泌経路 / 細胞内輸送 |
|---|
| Research Abstract |
Several “leaderless” proteins, which lack a consensus signal sequence, are secreted through unconventional secretory pathways. The mechanism by which leaderless proteins cross cell membranes is poorly understood. We have shown that nardilysin (N-arginine dibasic convertase: NRDc), a leaderless zinc peptidase, has localization-dependent multiple functions. Here, we demonstrate that the phosphorylation of NRDc is involved in the secretion.
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