Molecular Mechanism of Unconventional Secretory Pathway for "Leaderless" Proteins
Project/Area Number |
23659154
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
General medical chemistry
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Research Institution | Kyoto University |
Principal Investigator |
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 分泌タンパク質 / シグナルペプチド / 非古典的分泌経路 / ナルディライジン / タンパク質分泌経路 / 細胞内輸送 |
Research Abstract |
Several “leaderless” proteins, which lack a consensus signal sequence, are secreted through unconventional secretory pathways. The mechanism by which leaderless proteins cross cell membranes is poorly understood. We have shown that nardilysin (N-arginine dibasic convertase: NRDc), a leaderless zinc peptidase, has localization-dependent multiple functions. Here, we demonstrate that the phosphorylation of NRDc is involved in the secretion.
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Report
(3 results)
Research Products
(39 results)
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[Presentation] Nardilysin, an Activator of Ectodomain Shedding, is a Novel and Potent Biomarker for Acute Coronary Syndrome2013
Author(s)
Ohno M, Watanabe S, Hiraoka Y, Matsuoka T, Nishi K, Saijo S, Sakamoto J, Chen PM, Inoue K, Kita T, Kimura T, Nishi E
Organizer
第77回日本循環器学会総会
Place of Presentation
横浜
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[Presentation] Nardilysin, an activator of ectodomain shedding, is a novel and potent biomarker for acute Nardilysin, an activator of ectodomain shedding, is a novel and potent biomarker for acute Nardilysin, an activator of ectodomain shedding, is a novel and potent bi2012
Author(s)
Ohno M, Watanabe S, Hiraoka Y, Matsuoka T, Nishi K, Saijo S, Kita T, Nishi E, Kimura T.
Organizer
ESC Congress 2012
Place of Presentation
Munich(Germany)
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[Presentation] NRDc regulates circulatory dynamics through modulating sinus node automaticity and cardiac sympathetic innervation2012
Author(s)
Ohno M, Hiraoka Y, Matsuura H, Matsuoka T, Nishi K, Saijo S, Sakamoto J, Chen PM, Kita T, Kimura T, Nishi E
Organizer
Neuro-Vascular Wiring Symposium2012
Place of Presentation
Nara
Related Report
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[Presentation] Nardilysin, an activator of ectodomain shedding, is a novel and potent biomarker for acute coronary syndrome2012
Author(s)
Ohno M, Watanabe S, Hiraoka Y, Matsuoka T, Nishi K, Saijo S, Kita T, Nishi E, Kimura T.
Organizer
European Society of Cardiology, Congress 2012
Place of Presentation
Munich- Germany
Related Report
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[Presentation] NRDc regulates circulatory dynamics through modulating sinus node automaticity and cardiac sympathetic innervation2012
Author(s)
Ohno M, Hiraoka Y, Matsuura H, Matsuoka T, Nishi K, Saijo S, Sakamoto J, Chen PM, Kita T, Kimura T, Nishi E.
Organizer
Neuro-Vascular Wiring Symposium 2012
Place of Presentation
奈良
Related Report
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