| Project/Area Number |
23659155
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OHNISHI Hiroshi 群馬大学, 生体調節研究所, 准教授 (70334125)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 遺伝子 / シグナル伝達 / 生体分子 / マイクロアレイ / 老化 |
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| Research Abstract |
Cells constituting organs in the mammals have cell-type-specific life span after their terminal differentiation. The differences in cellular life span are though to be dependent on cell characteristics and functions. However, the molecular basis underlying the regulation of the life span of terminally differentiated cells is not fully elucidated. Moreover, the biological significance of cell-type-specific life span still remains unclear. To clarify the mechanism of the regulation of cellular life span, we performed approaches using mouse intestinal epithelial cells as a model.
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