Elucidation of the transcription factor network that regulates cancer-stroma interaction
| Project/Area Number |
23659168
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 分子腫瘍学 / 転写因子 / ケモカイン / サイトカイン / Bach1 |
|---|
| Research Abstract |
Interaction between stroma and cancer cells appears critical for the development of cancer. However, little is known about how the functions of stroma cells are regulated at the level of gene expression. In this project, we focused on the transcription factor Bach1 on which we had several preliminary observations suggesting its important roles in the cancer-stroma interaction. We found that Bach1 is critical for tumor formation in several mouse model systems. We identified downstream genes of Bach1 which appeared to be critical for the stroma function. We also studied the regulation of BACH1 in human stroma cells. These results will be an important foundation for future studies on the cancer-stroma interaction.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] BTB and CNC Homolog1 (Bach1) Deficiency Ameliorates TNBS Colitis in Mice: Role of M2 Macrophages and Heme Oxygenase-12013
Author(s)
Harusato A, Naito Y, Takagi T, Uchiyama K, Mizushima K, Hirai Y, Higashimura Y, Katada K, Handa O, Ishikawa T, Yagi N, Kokura S, Ichikawa H, Muto A, Igarashi K, Yoshikawa T
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Journal Title
Inflamm Bowel Disease
Volume: 19巻
Pages: 740-753
Related Report
Peer Reviewed
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[Journal Article] BTB and CNC Homolog 1 (Bach1) Deficiency Ameliorates TNBS Colitis in Mice: Role of M2 Macrophages and Heme Oxygenase-1.2013
Author(s)
Harusato A, Naito Y, Takagi T, Uchiyama K, Mizushima K, Hirai Y, Higashimura Y, Katada K, Handa O, Ishikawa T, Yagi N, Kokura S, Ichikawa H, Muto A, Igarashi K, Yoshikawa T.
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Journal Title
Inflamm Bowel Dis
Volume: 19
Pages: 740-753
Related Report
Peer Reviewed
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