| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Interaction between stroma and cancer cells appears critical for the development of cancer. However, little is known about how the functions of stroma cells are regulated at the level of gene expression. In this project, we focused on the transcription factor Bach1 on which we had several preliminary observations suggesting its important roles in the cancer-stroma interaction. We found that Bach1 is critical for tumor formation in several mouse model systems. We identified downstream genes of Bach1 which appeared to be critical for the stroma function. We also studied the regulation of BACH1 in human stroma cells. These results will be an important foundation for future studies on the cancer-stroma interaction.
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