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Generation of claudin targeted autoimmune disease mouse model

Research Project

Project/Area Number 23659172
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Pathological medical chemistry
Research InstitutionOsaka University

Principal Investigator

TSUKITA Sachiko  大阪大学, 生命機能研究科, 教授 (00188517)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords上皮細胞 / タイトジャンクション / 自己免疫疾患 / 自己抗体 / クローディン / ノックアウトマウス / Rag2/Jak3ノックアウトマウス / 炎症
Research Abstract

Autoimmune diseases, in which tissues of the body are pathologically attacked by an individual`s own immune system, are presently difficult to cure completely. Autoimmunogens are suggested to exist in almost all known autoimmune diseases, but their identity is not known in many cases. Notably, many autoimmune diseases are accompanied by inflammation in epithelial tissues. In this project, we propose that claudin, a major tight junction protein, is a target immunogen in some autoimmune diseases. To clarify the relationship between claudin and autoimmune diseases, we sought to generate a claudin-targeted autoimmune disease mouse model.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (25 results)

All 2013 2012 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (12 results) (of which Invited: 4 results) Remarks (5 results)

  • [Journal Article] Ezrin Is Required for the Functional Regulation of the Epithelial Sodium Proton Exchanger, NHE32013

    • Author(s)
      Hayashi H., et al
    • Journal Title

      PLoS One

      Volume: 8 Issue: 2 Pages: e55623-e55623

    • DOI

      10.1371/journal.pone.0055623

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Loss of claudins 2 and 15 from mice causes defects in paracellular Na(+) flow and nutritient transport in gut nad leads to death from malnutrition2013

    • Author(s)
      Wada, M., Tamura, A., Takahashi, N., and Tsukita, S.
    • Journal Title

      Gastroenterology

      Volume: 114 Pages: 369-380

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Loss of Claudins 2 and 15 From Mice Causes Defects in Paracellular Na(+) Flow and Nutrient Transport in Gut and Leads to Death from Malnutrition.2013

    • Author(s)
      Wada M., et al
    • Journal Title

      Gastroenterology

      Volume: 114 Pages: 369-380

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins2012

    • Author(s)
      Lei Z., et al
    • Journal Title

      Dev Biol.

      Volume: 371 Issue: 2 Pages: 136

    • DOI

      10.1016/j.ydbio.2012.07.005

    • URL

      https://pure.teikyo.jp/en/publications/7036e9cb-7d83-4ab2-942c-c4ab729fce84

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Moesin-deficient mice reveal a non-redundant role for moesin in lymphocyte homeostasis2012

    • Author(s)
      Hirata T., et al
    • Journal Title

      Int Immunol.

      Volume: 24 Issue: 11 Pages: 705

    • DOI

      10.1093/intimm/dxs077

    • URL

      https://pure.teikyo.jp/en/publications/a111f7cf-bfc5-40a3-9022-8915b8375687

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Claudin-based paracellular proton barrier in the stomach2012

    • Author(s)
      Tamura A., et al
    • Journal Title

      Ann N Y Acad Sci.

      Volume: 1258 Issue: 1 Pages: 108

    • DOI

      10.1111/j.1749-6632.2012.06570.x

    • URL

      https://pure.teikyo.jp/en/publications/01ea51f6-8f1c-48ec-af74-c96f40df7906

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rho GTP exchange factor ARHGEF11 regulates the integrity of epithelial junctions by connecting ZO-1 and RhoA-Myosin II signaling2012

    • Author(s)
      Itoh, M., Tsukita, S., Yamazaki, Y., and Sugimoto, H.
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 109 Issue: 25 Pages: 9905

    • DOI

      10.1073/pnas.1115063109

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of claudin-18 causes paracellular H<sup>+</sup> leakage, up-regulation of interleukin-1β, and atrophic gastritis in mice2012

    • Author(s)
      Hayashi, D., Tamura, A., Tanaka, H., Yamazaki, Y., Watanabe S. Suzuki, K., Suzuki, K. Sentani, K., Yasui, W., Rakugi, H., Isaka, Y., and Tsukita, S.
    • Journal Title

      Gastroenterology

      Volume: 142 Issue: 2 Pages: 292

    • DOI

      10.1053/j.gastro.2011.10.040

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Odf2 organizes two distinct appendage structures/functions in centrosomes and basalbodies2013

    • Author(s)
      Kazuhiro Tateishi
    • Organizer
      Computational Cell Biology: The Interplay between Models and Experimentation
    • Place of Presentation
      Cold Spring Harbor Laboratory, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Odf2 organizes two distinct appendage structures/functions in centrosomes and basalbodies.2013

    • Author(s)
      Kazuhiro Tateishi
    • Organizer
      Computational Cell Biology: The Interplay between Models and Experimentation.
    • Place of Presentation
      Cold Spring Harbor Laboratory
    • Related Report
      2012 Annual Research Report
  • [Presentation] Claudin species-specific biological functions in Digestive Epithelial Cells2012

    • Author(s)
      Sachiko Tsukita
    • Organizer
      International Conference Molecular Structure and Function of the Apical Junctional Complex in Epithelia and Endothelia.
    • Place of Presentation
      Hyatt Regency Hotel in Merida, Mexico
    • Year and Date
      2012-12-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Clitical Role of Basal Feet in Coorninated Ciliary Beating2012

    • Author(s)
      Sachiko Tsukita
    • Organizer
      ASCB annual meeting
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Molecular mechanisms of cell morphogenesis2012

    • Author(s)
      月田早智子
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Final Research Report
  • [Presentation] Tight Junction-based Building of Biological Systems2012

    • Author(s)
      Sachiko Tsukita
    • Organizer
      第33回日本肥満学会
    • Place of Presentation
      ホテルグランヴィア京都
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Tight Junction-based Building of Biological Systems2012

    • Author(s)
      Sachiko Tsukita
    • Organizer
      上皮バリアと上皮輸送に関する国際シンポジウム
    • Place of Presentation
      立命館大学びわ国際キャンパス
    • Related Report
      2012 Final Research Report
  • [Presentation] 上皮細胞間タイトジャンクションを起点とした生体システムの構築2012

    • Author(s)
      月田早智子
    • Organizer
      第21回日本バイオイメージング学会学術集会
    • Place of Presentation
      京都国際会館
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Clitical Role of Basal Feet in Coorninated Ciliary Beating.2012

    • Author(s)
      Sachiko Tsukita
    • Organizer
      ASCB annual meeting
    • Place of Presentation
      サンフランシスコ
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Molecular mechanisms of cell morphogenesis.2012

    • Author(s)
      月田早智子
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Tight Junction-based Building of Biological Systems.2012

    • Author(s)
      Sachiko Tsukita
    • Organizer
      上皮バリアと上皮輸送に関する国際シンポジウム
    • Place of Presentation
      立命館大学びわ国際キャンパス
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Claudin species-specific biological functions in Digestive Epithelial Cells.

    • Author(s)
      Sachiko Tsukita
    • Organizer
      International Conference Merida 2012 Molecular Structure and Function of the Apical Junctional Complex in Epithelia and Endothelia.
    • Place of Presentation
      Hyatt Regency Hotel in Merida
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Remarks] ホームページ

    • URL

      http://www.fbs.osaka-u.ac.jp/labs/tsukita/

    • Related Report
      2012 Final Research Report
  • [Remarks] 大阪大学大学院生命機能研究科分子生体情報学研究室

    • URL

      http://www.fbs.osaka-u.ac.jp/jpn/general/lab/13/

    • Related Report
      2012 Annual Research Report
  • [Remarks] 大阪大学大学院生命機能研究科/医学系研究科 月田研究室

    • URL

      http://www.fbs.osaka-u.ac.jp/labs/tsukita/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.fbs.osaka-u.ac.jp/jpn/general/lab/13/

    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.fbs.osaka-u.ac.jp/labs/tsukita/

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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