Generation of claudin targeted autoimmune disease mouse model
| Project/Area Number |
23659172
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 上皮細胞 / タイトジャンクション / 自己免疫疾患 / 自己抗体 / クローディン / ノックアウトマウス / Rag2/Jak3ノックアウトマウス / 炎症 |
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| Research Abstract |
Autoimmune diseases, in which tissues of the body are pathologically attacked by an individual`s own immune system, are presently difficult to cure completely. Autoimmunogens are suggested to exist in almost all known autoimmune diseases, but their identity is not known in many cases. Notably, many autoimmune diseases are accompanied by inflammation in epithelial tissues. In this project, we propose that claudin, a major tight junction protein, is a target immunogen in some autoimmune diseases. To clarify the relationship between claudin and autoimmune diseases, we sought to generate a claudin-targeted autoimmune disease mouse model.
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] Deficiency of claudin-18 causes paracellular H+ leakage, up-regulation of interleukin-1β, and atrophic gastritis in mice.2012
Author(s)
Hayashi, D., Tamura, A., Tanaka, H., Yamazaki, Y., Watanabe S. Suzuki, K., Suzuki, K. Sentani, K., Yasui, W., Rakugi, H., Isaka, Y., and Tsukita, S.
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Journal Title
Gastroenterology
Volume: 142
Issue: 2
Pages: 292-304
DOI
Related Report
Peer Reviewed
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