| Project/Area Number |
23659173
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | エピジェネティクス / 遺伝子発現 / ヒストン / メチル化 / 代謝調節 / 肥満 / エネルギー代謝 / 高脂肪食 / LSD1 / 阻害薬剤 / FAD |
|---|
| Research Abstract |
Environmental factors such as nutritional state act on the epigenome. The lysine demethylase LSD1 utilizes flavin adenosine dinucleotide(FAD) as a cofactor. We found that LSD1 regulates energy expenditure genes in the cellular FAD-dependent manner. This study shows a novel mechanism where LSD1 is involved in metabolic regulation, leading to development of therapeutic potentials.
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