| Project/Area Number |
23659174
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Yokohama City University |
|---|
Principal Investigator |
OHNO Shigeo 横浜市立大学, 医学研究科, 教授 (10142027)
|
|---|
| Project Period (FY) |
2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
|
|---|
| Keywords | 細胞極性 / PAR3 / aPKC / podocytes / Nephrin |
|---|
| Research Abstract |
Previous studies on podocyte-specific aPKC KO mice that shows focal glomerular sclerosis have revealed the importance of the dynamics of Nephrin, a major slit membrane protein, for this disease. Here we evaluated the dunamics of Nephrin using epithelial cells, isolated glomerulus, and the cKO mice in vivo, and found the importance of the process of the membrane traffic in this disease.
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