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Oxygen sensor as a target of type-2 DM treatment

Research Project

Project/Area Number 23659175
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Pathological medical chemistry
Research InstitutionKeio University

Principal Investigator

MINAMISHIMA Yoji Andrew  慶應義塾大学, 医学部, 講師 (20593966)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords低酸素 / HIF / PHD / 糖尿病 / インスリン感受性 / インスリン抵抗性 / 代謝 / 低酸素応答 / メタボローム
Research Abstract

Hypoxic response is mainly regulated by VHL-PHD-HIF pathway. Systemically activating HIF in mice clearly shows blood sugar lowering effect and upregulated insulin sensitivity. Our result would highlight on a new concept of type-II diabetes treatment which target hypoxic response pathway.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (30 results)

All 2014 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (17 results) (of which Invited: 8 results) Book (7 results) Remarks (4 results)

  • [Journal Article] Energy management by enhanced glycolysis in G1 phase in human colon cancer cells in vivo and in vitro2013

    • Author(s)
      Bao Y, Mukai K, Hishiki T, Kubo A, Ohmura M, Sugiura Y, Matsuura T, Nagahata Y, Hayakawa N, Yamamoto T, Fukuda R, Saya H, Suematsu M, Minamishima YA
    • Journal Title

      Mol Cancer Res

      Volume: 11(9) Pages: 973-985

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men12011

    • Author(s)
      Lin W, Cao J, Liu J, Beshiri ML, Fujiwara Y, Francis J, Cherniack AD, Geisen C, Blair LP, Zou MR, Shen X, Kawamori D, Liu Z, Grisanzio C, Watanabe H, Minamishima YA, et al
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 108 Issue: 33 Pages: 13379-86

    • DOI

      10.1073/pnas.1110104108

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] PHD2-HIF dependent hypoxic response regulates Cori cycle2014

    • Author(s)
      Masataka Kasahara, Tomohiro Suhara, Noriyo Hayakawa, Makoto Suematsu, Yoji Andrew Minamishima
    • Organizer
      Keystone Symposia "Sensing and Signaling of Hypoxia: Interfaces with Biology and Medicine (A1)"
    • Place of Presentation
      Breckenridge, CO, U.S.A
    • Year and Date
      2014-01-09
    • Related Report
      2013 Final Research Report
  • [Presentation] PHD2-HIF dependent hypoxic response regulates Cori cycle2014

    • Author(s)
      Masataka Kasahara, Tomohiro Suhara, Noriyo Hayakawa, Makoto Suematsu, Yoji Andrew Minamishima
    • Organizer
      Keystone Symposia “Sensing and Signaling of Hypoxia: Interfaces with Biology and Medicine (A1)"
    • Place of Presentation
      Breckenridge, CO, U.S.A
    • Related Report
      2013 Annual Research Report
  • [Presentation] 低酸素応答とin vivo 糖・乳酸代謝2013

    • Author(s)
      南嶋洋司, 笠原正貴, 寿原明宏, 早川典代, 末松誠
    • Organizer
      第11回がんとハイポキシア研究会
    • Place of Presentation
      東北大学片平さくらホール
    • Year and Date
      2013-12-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulation of energy metabolism by hypoxic response in vivo2013

    • Author(s)
      南嶋洋司, 笠原正貴, 早川典代, 寿原明宏, 末松誠
    • Organizer
      第36回分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2013-12-03
    • Related Report
      2013 Final Research Report
  • [Presentation] 低酸素応答や細胞周期と細胞内エネルギー代謝制御2013

    • Author(s)
      南嶋洋司, 末松誠
    • Organizer
      第1回がんと代謝研究会
    • Place of Presentation
      慶應義塾大学先端生命科学研究所 鶴岡メタボロームキャンパス
    • Year and Date
      2013-10-31
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 低酸素応答によるエネルギー代謝制御機構~臓器間のクロストーク~2013

    • Author(s)
      南嶋洋司, 末松誠
    • Organizer
      第1回低酸素研究会
    • Place of Presentation
      早稲田大学先端生命医科学センター (TWIns)
    • Year and Date
      2013-07-06
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 低酸素応答によるin vivoエネルギー代謝の制御2013

    • Author(s)
      南嶋洋司、笠原正貴、早川典代、寿原明宏、末松誠
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 低酸素応答とin vivo糖・乳酸代謝2013

    • Author(s)
      南嶋洋司、笠原正貴、寿原明宏、早川典代、末松誠
    • Organizer
      第11回がんとハイポキシア研究会
    • Place of Presentation
      東北大学片平さくらホール
    • Related Report
      2013 Annual Research Report
  • [Presentation] 低酸素応答によるエネルギー代謝制御機構~臓器間のクロストーク~2013

    • Author(s)
      南嶋洋司、末松誠
    • Organizer
      第1回低酸素研究会
    • Place of Presentation
      早稲田大学先端生命医科学センター (TWIns)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] PHD as a therapeutic target2012

    • Author(s)
      Yoji Andrew Minamishima
    • Organizer
      The 33rd Naito Conference
    • Place of Presentation
      シャトレーゼガトーキングダムサッポロ(北海道)
    • Related Report
      2012 Research-status Report
  • [Presentation] In vivo Gas Biology~低酸素および硫化水素への生体応答が、細胞・個体に与える影響~2012

    • Author(s)
      南嶋 洋司
    • Organizer
      北海道大学大学院薬学研究院/日本薬学会北海道支部特別講演会
    • Place of Presentation
      北海道大学(北海道)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] In vivo Gas Biology~低酸素および硫化水素への生体応答が、細胞・個体に与える影響~2012

    • Author(s)
      南嶋 洋司
    • Organizer
      第6回東北眼疾患病態研究会
    • Place of Presentation
      東北大学(宮城)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] In vivo Gas Biology~低酸素および硫化水素への生体応答が、細胞・個体に与える影響~2012

    • Author(s)
      南嶋 洋司
    • Organizer
      宮崎大学先端的医学獣医学特論(大学院特別セミナー
    • Place of Presentation
      宮崎大学(宮崎)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] シンポジウム:低酸素応答が制御する多彩な生命現象 -生理機能の解明から疾患に迫る-2012

    • Author(s)
      南嶋 洋司
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場、マリンメッセ福岡(福岡)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Hypoxic response and cellular metabolism2012

    • Author(s)
      Yoji Andrew Minamishima
    • Organizer
      Cancer Area Meeting, Graduate School of Medicine, Kyoto University
    • Place of Presentation
      Kyoto University(京都)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 急性あるいは慢性的な低酸素応答が心筋に与える好影響と悪影響2011

    • Author(s)
      南嶋洋司
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Research-status Report
  • [Presentation] シンポジウム:低酸素バイオロジーの最前線:生理機能から疾患制御まで2011

    • Author(s)
      南嶋洋司
    • Organizer
      第84回日本生化学会大会(招待講演)
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2011 Research-status Report
  • [Book] 実験医学別冊 2013年別冊2013

    • Author(s)
      南嶋洋司
    • Related Report
      2013 Final Research Report
  • [Book] 血管医学 13(4)2012

    • Author(s)
      南嶋洋司
    • Related Report
      2013 Final Research Report
  • [Book] 腎臓 35(2)2012

    • Author(s)
      南嶋洋司, William G. Kaelin Jr., 末松誠
    • Related Report
      2013 Final Research Report
  • [Book] 実験医学 30(8)2012

    • Author(s)
      南嶋洋司, 末松誠
    • Related Report
      2013 Final Research Report
  • [Book] 実験医学2012

    • Author(s)
      南嶋 洋司
    • Total Pages
      6
    • Publisher
      羊土社
    • Related Report
      2012 Research-status Report
  • [Book] 血管医学2012

    • Author(s)
      南嶋 洋司
    • Total Pages
      7
    • Publisher
      メディカルビュー社
    • Related Report
      2012 Research-status Report
  • [Book] 腎臓2012

    • Author(s)
      南嶋 洋司
    • Total Pages
      5
    • Publisher
      日本腎臓財団
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.jst.go.jp/erato/suematsu/contents/member.html

    • Related Report
      2013 Final Research Report
  • [Remarks] JST, ERATO, 末松ガスバイオロジープロジェクト

    • URL

      http://gasbio.jst.go.jp

    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://gasbio.jst.go.jp/contents/achievement.html

    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://researchmap.jp/minamishima/

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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