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Research on the mechanism of tumorigenesis by A20 dysfunction in HCV-infected B cells

Research Project

Project/Area Number 23659177
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Pathological medical chemistry
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

KUSUNOKI Hideki  国立感染症研究所, 血液・安全性研究部, 主任研究官 (90334060)

Co-Investigator(Renkei-kenkyūsha) MIZUOCHI Toshiaki  国立感染症研究所, 血液・安全性研究部, 室長 (30135701)
OKUMA Kazu  国立感染症研究所, 血液・安全性研究部, 室長 (80315085)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsA20 / B 細胞リンパ腫 / HCV 感染 / 分子腫瘍学 / B細胞リンパ腫 / HCV感染
Research Abstract

In this study, we investigated the mechanism of tumorgenesis by A20 dysfunction in HCV-infected B cells. We found that A20, a negative regulator of the canonical NF-κB pathway, was dramatically enhanced and partially cleaved in HCV-infected B cells. When the possibility of A20 cleavage by HCV NS3 protease was examined, the direct result, which shows the A20 cleavage by its protease, was not obtained. We also found that MALT1 was enhanced in CHC B cells. Thus, this observation suggests that enhanced expression of MALT1 in HCV-infected B cells may cleave A20.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (4 results)

All 2011

All Journal Article (4 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] HCV infection and B-cell lymphomagenesis.2011

    • Author(s)
      M. Ito, H. Kusunoki, K. Mochida, K. Yamaguchi,and T. Mizuochi
    • Journal Title

      Advanced in Hematology

      Volume: Volume 2011

    • Related Report
      2012 Final Research Report
  • [Journal Article] Peripheral B cells as reservoirs for persistent HCV infection.2011

    • Author(s)
      M. Ito, H. Kusunoki, and T. Mizuochi
    • Journal Title

      Frontiers in Microbiology

      Volume: Volume 2 Pages: 177-177

    • Related Report
      2012 Final Research Report
  • [Journal Article] HCV infection and B-cell lymphomagenesis2011

    • Author(s)
      Ito, M., Kusunoki H., Mizuochi T.
    • Journal Title

      Adv.Hematol.

      Volume: 2011 Pages: 835314-835314

    • DOI

      10.1155/2011/835314

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Peripheral B cells as reservoirs for persistent HCV infection2011

    • Author(s)
      Ito, M., Kusunoki H., Mochida, K., Yamaguchi, K., Mizuochi T.
    • Journal Title

      Front.Microbiol.

      Volume: 2 Pages: 177-177

    • DOI

      10.3389/fmicb.2011.00177

    • Related Report
      2011 Research-status Report
    • Peer Reviewed

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Published: 2011-08-05   Modified: 2019-07-29  

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