| Project/Area Number |
23659179
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
SAKAMOTO Aiji 独立行政法人国立循環器病研究センター, 研究所, 室長 (40291067)
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| Co-Investigator(Renkei-kenkyūsha) |
ONO Kageyoshi 帝京大学, 薬学部, 教授 (40177259)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 心臓病 / 1心臓病 / 発症原因遺伝子 / 生体内防護機構 |
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| Research Abstract |
We are aiming to find unexpected molecular mechanisms underlying various diseases by using natural mutant hamsters. In this study, we found that BIO14.6 cardiomyopathic hamster had a point mutation in βB1-crystallin gene, causing the loss of its protein product in the heart. Furthermore, we created a new hamster line lacking βB1-crystallin protein by crossing normal and BIO14.6 hamsters. This study will set a basis to elucidate the cardiac roles ofβB1-crystallin, which has been recognized as a lens-specific protein so far.
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