Identification of molecular target and its therapeutic application for micropapillary adenocarcinoma

• Project/Area Number: 23659189
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Jichi Medical University
• Principal Investigator: NIKI Toshiro 自治医科大学, 医学部, 教授 (90198424)
• Co-Investigator(Kenkyū-buntansha): MATSUBARA Daisuke 自治医科大学, 医学部, 助教 (80415554)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 肺腺癌 / 浸潤 / 転移

Research Abstract

In this study, we sought to generate in vitro and in vivo model of micropapillary adenocarcinoma by long-term culture on low-binding culture dish. Of the 40 lung adenocarcinoma cell lines, we obseved micropapillary clusters in 24 cell lines.

Research Products

• [Journal Article] Lung Cancer with Loss of BRG1/BRM, shows Epithelial Mesenchymal Transition Phenotype and Distinct Histologic and Genetic Features. (2013)
  • Author(s): Matsubara D, Niki T (13thof 13)
  • Journal Title: Cancer Sci Volume: 104 Pages: 266-273
• [Journal Article] Lung cancer with loss of BRG1?BRM,shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features. (2013)
  • Author(s): Matsubara D, Murakami Y, Niki T et al.
  • Journal Title: Cancer Sci Volume: 104 Issue: 2 Pages: 266-273
  • DOI: 10.1111/cas.12065
  • Peer Reviewed
• [Journal Article] Identification of CCDC6-RET Fusion in the Human Lung Adenocarcinoma Cell Line (2012)
  • Author(s): Matsubara D, Niki T (14thof 14)
  • Journal Title: LC-2/ad. J Thorac Oncol. Volume: 7 Pages: 1872-1876
• [Journal Article] Epidermal growth factor receptor mutation and chemosensitivity. (2012)
  • Author(s): Matsubara D, Niki T
  • Journal Title: J Thorac Oncol Volume: 4 Pages: 771-772
  • Peer Reviewed
• [Journal Article] Identification of CCDC6-RET fusion in the human lung adenocarcinoma cell line, LC-2/ad. (2012)
  • Author(s): Matsubara D, Murakami Y, Niki T et al.
  • Journal Title: J Thorac Oncol Volume: 7 Issue: 12 Pages: 1872-1876
  • DOI: 10.1097/jto.0b013e3182721ed1
  • Peer Reviewed
• [Journal Article] (Letter to the Editor) Epidermal Growth Factor Receptor Mutati on and Chemosensitivity (2012)
  • Author(s): Matsubara D, Niki T
  • Journal Title: Journal of Thoracic Oncology Volume: 7 Issue: 4 Pages: 771-772
  • DOI: 10.1097/jto.0b013e318245a058
  • Peer Reviewed
• [Journal Article] Lung Adenocarcinoma, Mixed Subtype: Histopathologic Basis for High-Resolution Computed Tomography Findings. (2011)
  • Author(s): Terasaki H, Niki T (5thof 8)
  • Journal Title: J Thorac Imaging Volume: 26 Pages: 74-81
  • Peer Reviewed
• [Journal Article] Human papillomavirus infection in lung and esophageal cancers: Analysis of 485 Asian cases. (2011)
  • Author(s): Goto A, Niki T (4thof 17)
  • Journal Title: J Med Virol Volume: 83 Pages: 1383-1390
  • Peer Reviewed
• [Presentation] Histopathologic and genetic features of lung adenocarcinomas with loss of chromatin remodeling factors, BRG-1 and BRM. (2012)
  • Author(s): Matsubara D, Niki T (5th of 5)
  • Organizer: Annual Meeting of American Association for Cancer Research (poster presentation)
  • Place of Presentation: Chicago
• [Presentation] KRAS 変異,EMT 形質を有する肺腺癌細胞の薬剤感受性 (2012)
  • Author(s): 仁木 利郎、松原 大祐、石川 俊平、A BC DAB深山 正久
  • Organizer: 第53回日本肺癌学会総会
  • Place of Presentation: 岡山
• [Presentation] 原発性肺腺癌におけるクロマチンリモデリング因子 BRG1 及び BRMの欠損と上皮間葉系転換との関連性について. (2012)
  • Author(s): 松原 大祐、喜舎場由香、石川 俊平、村上 善則、油谷 浩幸、深山 正久、仁木 利郎
  • Organizer: 第53回日本肺癌学会総会
  • Place of Presentation: 岡山
• [Presentation] 肺腺癌における Snail の発現についての免疫組織学的検討 (2012)
  • Author(s): 喜舎場由香, 松原大祐, 仁木利郎
  • Organizer: 第101回日本病理学会
  • Place of Presentation: 京王プラザホテル
• [Presentation] 肺腺癌におけるSnail の発現についての免疫組織学的検討. (2012)
  • Author(s): 仁木利郎
  • Organizer: 日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] KRAS変異，EMT形質を有する肺腺癌細胞の薬剤感受性． (2012)
  • Author(s): 仁木利郎
  • Organizer: 日本肺癌学会総会
  • Place of Presentation: 岡山
• [Presentation] 原発性肺腺癌におけるクロマチンリモデリング因子BRG1及びBRMの欠損と上皮間葉系転換との関連性について (2012)
  • Author(s): 仁木利郎
  • Organizer: 日本肺癌学会総会
  • Place of Presentation: 岡山
• [Presentation] Expressions of bronchial epithelial markers correlate with morphology and genetic abnormalities in lung adenocarcinoma. (2011)
  • Author(s): Matsubara D, Niki T (4th of 4)
  • Organizer: 70th Annual Meeting of the Japanese Cancer Association (poster presentation)
  • Place of Presentation: Nagoya
• [Presentation] Three dimensional culture reveals genetic-morphologic correlations that may be relevant to classification of lung adenocarcinomas. (2011)
  • Author(s): Niki T, Matsubara D, Ishikawa S, Fukayama M
  • Organizer: 14th World Conference of Lung Cancer (poster presentation)
  • Place of Presentation: Amsterdam
• [Presentation] Lung adenocarcinomas show genetic-morphologic correlations in three dimensional culture. (2011)
  • Author(s): Matsubara D, Niki T (4th of 4)
  • Organizer: Annual Meeting of American Association for Cancer Research (poster presentation)
  • Place of Presentation: Orlando
• [Presentation] 肺腺癌細胞株の遺伝子発現データに基づく分類と、 3 次元培養下の細胞形態、遺伝子異常の関連性について. (2011)
  • Author(s): 松原大祐,石川俊平,深山正久,仁木利郎
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 東京,ポスター発表
• [Presentation] 一般示説(病理):肺腺癌症例の気管支上皮マーカーの発現に基づく分類:組織学的形態、遺伝子異常、 EGFR,METの活性化との関連. (2011)
  • Author(s): 松原大祐, 石川俊平,深山正久,仁木利郎
  • Organizer: 第52回日本肺癌学会総会
  • Place of Presentation: 大阪
• [Presentation] Lung adenocarcinomas show genetic-morphologic correlations in three dimensional culture. (2011)
  • Author(s): Matsubara D, Ishikawa S, Fukayama M, Niki T
  • Organizer: Annual Meeting of American Association for Cancer Research
  • Place of Presentation: Orlando, USA
• [Presentation] Expressions of bronchial epithelial markers correlate with morphology and genetic abnormalities in lung adenocarcinoma. (2011)
  • Author(s): Matsubara D, Ishikawa S, Fukayama M, Niki T.
  • Organizer: 70th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Nagoya, Japan
• [Presentation] 肺腺癌症例の気管支上皮マーカーの発現に基づく分類：組織学的形態、遺伝子異常、EGFR,METの活性化との関連. (2011)
  • Author(s): 松原大祐, 石川俊平，深山正久，仁木利郎.
  • Organizer: 第52回日本肺癌学会総会
  • Place of Presentation: 大阪
• [Presentation] 肺腺癌細胞株の遺伝子発現データに基づく分類と、3次元培養下の細胞形態、遺伝子異常との関連性について. (2011)
  • Author(s): 松原大祐, 石川俊平，深山正久，仁木利郎.
  • Organizer: 第100回日本病理学会
  • Place of Presentation: 横浜
• [Remarks]
  • URL: http://www.jichi.ac.jp/pathol/