Acceleration of colitis in vitamin A deficiency: Demonstrationby experimental mouse model
| Project/Area Number |
23659190
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Kitasato University |
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Principal Investigator |
OKAYASU Isao 北里大学, 医学部, 名誉教授 (20014342)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ビタミンA欠乏 / 大腸炎 / 下痢 / 大腸粘膜 / 上皮下筋線維芽細胞 / 潰瘍性大腸炎モデル / デキストラン硫酸 / ビタミンＡ / 粘膜上皮下筋線維芽細胞 / 伊東細胞 / ＤＳＳ大腸炎 / 潰瘍性大腸炎 / ビタミンＡ欠乏 / DSS 大腸炎 / 樹状細胞 |
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| Research Abstract |
To see the influence of vitamin A deficiency on colitis, Dextran sulfate sodium-colitis was induced in vitamin A deficient and vitamin A-supplemented mice. Colitis was significantly severer in vitamin A deficient mice than vitamin A-supplemented mice. cDNA microarray analysis showed different gene expression between two groups, suggesting some relation to acceleration of colitis. Thus, it is demonstrated that vitamin A supplement might improve chronic diarrhea or colitis in low nutrient infants.
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Report
(3 results)
Research Products
(6 results)
