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Chimerism of human transplanted liver and possibility of anti-aging effect of chimera hepatocytes

Research Project

Project/Area Number 23659193
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Human pathology
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Principal Investigator

TAKUBO Kaiyo  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (00154956)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords生体肝移植 / 臨床病理学的研究 / テロメア / キメラ / 肝移植 / 移植肝 / キメリズム / FISH / 抗老化
Research Abstract

Based on the analysis on the database of the patients of living-donor liver transplantation (LDLT), it was indicated that maternal grafts protected daughter and son recipients from acute rejection after pediatric LDLT for biliary atresia. It was suggested that younger donors were better for LDLT patients to leave immunosuppressant. Q-FISH measurement of hepatocyte telomere lengths in donor liver and graft after LDLT indicated that donor age was a crucial factor affecting telomere length sustainability in hepatocytes after pediatric LDLT, and that the telomeres in grafts may be elongated somewhat longer when the grafts were immunologically well controlled.In the maternal grafts, many Y chromosome positive cells (mainly, endothelial cells) from son recipients were observed, whereas Y-chromosome and keratin-positive cells were very scanty in the grafts.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (12 results)

All 2014 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (4 results) Remarks (4 results)

  • [Journal Article] Maternal grafts protect daughter recipients from acute cellular rejection after pediatric living donor liver transplantation for biliary atresia.2014

    • Author(s)
      Sanada Y, Kawano Y, Miki A, Aida J, Nakamura K, Izumiyama NS, Ishikawa N, Arai T, Hirata Y, Yamada N, Okada N, Wakiya T, Ihara Y, Urahashi T, Yasuda Y, Takubo K.
    • Journal Title

      Transpl Int

      Volume: 27 Issue: 4 Pages: 383-90

    • DOI

      10.1111/tri.12273

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Q-FISH measurement of hepatocyte telomere lengths in donor liver and graft after pediatric living-donor liver transplantation: Donor age affects telomere length sustainability.2014

    • Author(s)
      Kawano Y., Ishikawa N., Aida J., Sanada Y., Izumiyama-Shimomura N., Nakamura K., Poon SSS., Matsumoto K., Mizuta K., Uchida E., Tajiri T., Kawarasaki H., Takubo K.
    • Journal Title

      PLoS ONE

      Volume: 9 Issue: 4 Pages: 1-10

    • DOI

      10.1371/journal.pone.0093749

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hepatocellular Telomere Length in Biliary Atresia Measured by Q-FISH2014

    • Author(s)
      Sanada Y, Aida J, Kawano Y, Nakamura KI, Shimomura N, Ishikawa N, Arai T, Poon SS, Yamada N, Okada N, Wakiya T, Hayashida M, Saito T, Egami S, Hishikawa S, Ihara Y, Urahashi T, Mizuta K, Yasuda Y, Kawarasaki H, Takubo K
    • Journal Title

      World J Surg

      Volume: 36 Pages: 908-916

    • Related Report
      2013 Final Research Report
  • [Journal Article] Hepatocellular Telomere Length in Biliary Atresia Measured by Q-FISH2012

    • Author(s)
      Sanada Y, Aida J, Kawano Y, Nakamura KI, Shimomura N, Ishikawa N, Arai T, Poon SS, Yamada N, Okada N, Wakiya T, Hayashida M, Saito T, Egami S, Hishikawa S, Ihara Y, Urahashi T, Mizuta K, Yasuda Y, Kawarasaki H, Takubo K.
    • Journal Title

      World J Surg

      Volume: 36 Issue: 4 Pages: 908-916

    • DOI

      10.1007/s00268-012-1453-z

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Q-FI SH法により測定したテロメア長を指標とした超百歳リンパ球から樹立されたiPS細胞の評価2013

    • Author(s)
      仲村賢一, 広瀬信行, 下村-泉山七生貴, 相田順子, 石川直, 田久保海誉
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] iPS細胞化によるリプログラミング過程でのテロメア動態のQ-FISH法による解析2013

    • Author(s)
      石川直, 仲村賢一, 下村-泉山七生貴, 相田順子, 寺井政憲, 豊田雅士, 田久保海誉
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] Q-FISH法により測定したテロメア長を指標とした超百歳リンパ球から樹立されたiPS細胞の評価2013

    • Author(s)
      仲村賢一、広瀬信行、下村-泉山七生貴、相田順子、石川直、田久保海誉
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] iPS細胞化によるリプログラミング過程でのテロメア動態のQ-FISH法による解析2013

    • Author(s)
      石川直、仲村賢一、下村-泉山七生貴、相田順子、寺井政憲、豊田雅士、田久保海誉
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Remarks] 東京都健康長寿医療センター研究所老年病理学研究チーム 高齢者がん研究グループ独自ホームページ

    • URL

      http://www.ttaggg-rtgp.org/

    • Related Report
      2013 Final Research Report
  • [Remarks] 東京都健康長寿医療センター研究所 老年病理学研究チーム 高齢者がんグループ ホームページ

    • URL

      http://www.ttaggg-rtgp.org/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 東京都健康長寿医療センター研究所老年病理学研究チーム高齢者がん研究グループ

    • URL

      http://www.ttaggg-rtgp.org/

    • Related Report
      2012 Research-status Report
  • [Remarks] グループのホームページURL:

    • URL

      http://www.ttaggg-rtgp.org/

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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