Analysis of the regulatory mechanism of IL-17/IL-22 production during bacterial infection
| Project/Area Number |
23659200
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Experimental pathology
|
|---|
| Research Institution | The University of Tokyo (2012)
Tokyo Medical and Dental University (2011) |
|---|
Principal Investigator |
OKAMOTO Kazuo 東京大学, 大学院・医学系研究科, 助教 (00436643)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 炎症 / 免疫学 / サイトカイン / 感染症 / Th17細胞 / 病理学 |
|---|
| Research Abstract |
To clarify the regulatory mechanism of IL-17 and IL-22 production in response to bacterial infection, we analyzed the spatio-temporal behavior of Th17 cells and IL-17/IL-22-producing innate lymphoid cells during bacterial infection, using the reporter mice for visualization of Th17-related cytokine. Furthermore, we performed transcriptome analyses of IL-17-producing cells and IL-22-producing cells, and explored the factors which may regulate the expression of IL-22 in Th17 cells or IL-17/IL-22-producing innate lymphoid cells.
|
Report
(3 results)
Research Products
(33 results)
