| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
To clarify the regulatory mechanism of IL-17 and IL-22 production in response to bacterial infection, we analyzed the spatio-temporal behavior of Th17 cells and IL-17/IL-22-producing innate lymphoid cells during bacterial infection, using the reporter mice for visualization of Th17-related cytokine. Furthermore, we performed transcriptome analyses of IL-17-producing cells and IL-22-producing cells, and explored the factors which may regulate the expression of IL-22 in Th17 cells or IL-17/IL-22-producing innate lymphoid cells.
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