| Project/Area Number |
23659203
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Kyoto University |
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Principal Investigator |
INABA Kayo 京都大学, 大学院・生命科学研究科, 教授 (00115792)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHARA Kazuhiko 京都大学, 大学院・生命科学研究科, 講師 (90301233)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 炎症 / ナノ粒子 / サイズ効果 / マクロファージ / サイトカイン / ラテックスビーズ |
|---|
| Research Abstract |
Small particles, such as asbestos and silica, cause inflammatory cellular responses, leading to various types of diseases. In this study, we investigated production mechanism of pro-inflammatory cytokine IL-1β. Using size-fractionated silica particles and size-defined latex beadsas stimulators, it was indicated that bone marrow-derived macrophagesuse distinct cellular pathway of IL-1βproduction in a particle size-dependent manner.
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