| Project/Area Number |
23659207
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKITA Naoyuki 東京理科大学, 薬学部, 助教 (60453841)
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| Project Period (FY) |
2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | p53 / WWP1 / ユビキチンリガーゼ / 脂肪細胞 / 肥満症 |
|---|
| Research Abstract |
It is well known that tumor suppressor p53 transcriptionally regulates the expression of several E3 ubiquitin ligases and the ligases post-translationally modulate p53 itself. We found that the expression of p53-targeted E3 ubiquitin ligase WWP1 was specifically up-regulated in white adipose tissue(WAT) of obese mice. An insulin administration reduced the expression of WWP1 protein in WAT in obese mice. Moreover, a knockdown for WWP1 suppressed adipocyte differentiation in 3T3-L1 preadipocyte cell line. Our findings suggest that WWP1 is a novel marker protein of obese WAT, and its expression is regulated by both p53 and insulin.
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