| Project/Area Number |
23659209
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
OHTA Nobuo 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (10143611)
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| Co-Investigator(Renkei-kenkyūsha) |
KUMAGAI Takashi 東京医科歯科大学, 大学院医歯学総合, 助教 (40369054)
SHIMOGAWARA Rieko 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (50146776)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 住血吸虫 / セルカリア / 誘引行動 / リノール酸 / 認識センサー / RNA 干渉 / マンソン住血吸虫 / RNA干渉 / センサー遺伝子 |
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| Research Abstract |
In the hope of uncovering sensor system of digenic platyhelminthes, we analyzed possible sensor organs of cercariae Schistosoma manosin. Cercariae of S. manosini were strongly attracted by linoleic acid and the responsible sensor seemed to be detected on the surface of cercariae. It was needed to test the direct effects of the probable sensors, and RNAi was applied for schistosoma cercariae. There are still technical matters left for RNAi at the cercarial stage. Results of the current study seem to lead development of reagents to avoid schistosomal infection targeting the skin penatration of cercariae.
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