| Project/Area Number |
23659212
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Okayama University |
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Principal Investigator |
WATAYA Yusuke 岡山大学, 大学院・医歯薬学総合研究科, 名誉教授 (90127598)
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| Co-Investigator(Kenkyū-buntansha) |
KIM Hye-sook 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (70314664)
SATO Akira 岡山大学, 大学院・医歯薬学総合研究科, 助教 (40530663)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | リーシュマニア原虫 / アンチモン製剤 / 抗リーシュマニア活性評価 / Geldanamycin / Hsp90 / Leishmania major / Leishmania donovani / 天然生薬資源 / 感染症 / リーシュマニア / 創薬 / 難治性疾患 / 核酸誘導体 |
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| Research Abstract |
I performed to new drug discovery research for 68 compounds from organic compounds and natural product using promastigotes of Leishmania major. The EC50values among 2 of them for L. majorwere 42 nM and 27 nM. In contrast, Amphotericin B as a positive control was show 63 nM of EC50value for L. majorand selective toxicity of 46-fold compare tomammalian cells of it. The structure-activity relationship study will be need more. I established the mechanism analysis of HSP90 and complex relationship in L. major and also we found the high anti-leishmanial effect for HSP90 inhibitor and it’s analogs include small molecules (EC50values; 30-40 nM) against L. major promastigotes.
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