Screening of anti-tumor metastatic substances using salivary gland of blood feed animals and snake venom
| Project/Area Number |
23659216
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | がん細胞 / 転移抑制 / 唾液腺 / 凝固阻害 / ルシフェリン / ルシフェラーゼ / ヒルジン / アスピリン / マウスがん細胞 / in vivo imaging system / 転移 / 吸血動物 / 抗凝固物質 / 節足動物 / 生物資源 / 遺伝子導入 / 蚊 / 蛭 / 蛇毒 |
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| Research Abstract |
Using a mouse colon cancer cell line (Colon26) I made screening for anti-tumor metastatic substances. Since Colon26 contains luciferase in the genome, you can monitor the cell grow by in vivo imaging system if the cancer cells grow in mouse body. The tested materials were mosquitoe salivary gland, salivary part of leech, hirudin (purified leech saliva), heparin and aspirin. Indeed I repeated the screening tests for several times, I failed to find anti-tumor metastatic substance.
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Report
(4 results)
Research Products
(36 results)
