Development of the molecular imaging agent for the diagnostic imaging of a deep mycosis and a bacterial infectious disease

• Project/Area Number: 23659221
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Bacteriology (including Mycology)
• Research Institution: University of Fukui
• Principal Investigator: NORIKI Sakon 福井大学, 医学部, 准教授 (30228374)
• Co-Investigator(Renkei-kenkyūsha): INAI Kunihiro 福井大学, 医学部, 助教 (30313745) ; KIYONO Yasushi 福井大学, 高エネルギー医学研究センター, 教授 (50305603) ; IDO Tatsuo 福井大学, 高エネルギー医学研究センター, 客員教授 (80134063)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 診断 / PET / 感染症 / 分子イメージング / 感染巣 / 画像化 / 抗生物質 / 治療効果 / 合成方法 / FAG

Research Abstract

We synthesized N-[18F]Fluoroacetyl-D- glucosamine (18F-GlcNAc: FAG), As a molecular imaging agent specifically taken into the fungus and bacteria.We proved that we can specifically image the infection nest in the living body by FAG-PET for the rats with bacterial infection and noninfectious inflammation. Moreover, we confirmed the curative effects of antibiotic by time-dependent changes of FAG-PET images of the infection rat medicated with the antibiotic.Furthermore, I newly compounded two kinds of precursor for FAG synthesis, and have improved yield of FAG

Research Products

• [Journal Article] New radiosynthesis of 2-deoxy-2-[(18)F]fluoro acetamido-D-glucopyranose and its evaluation as a bacterial infections imaging agent (2011)
  • Author(s): Martinez ME, Kiyono Y, Noriki S, Inai K, Mandap KS, Kobayashi M, Mori T, Tokunaga Y, Tiwari VN, Okazawa H, Fujibayashi Y, Ido T
  • Journal Title: Nucl Med Biol Volume: 38(6) Pages: 807-17
  • Peer Reviewed
• [Journal Article] 感染症診断のための分子イメージング剤の開発 (2011)
  • Author(s): 法木左近、稲井邦博、清野泰、Miguel E Martinez、藤林靖久、井戸達雄
  • Journal Title: 映像情報メディカル Pages: 734-736
  • URL: http://www.de-hon.ne.jp/digital/bin/product.asp?sku=2000003262547701500P
• [Journal Article] New radiosynthesis of 2-deoxy-2-[^<18> F] fluoroacetamido-D-glucopyranose and its evaluation as a bacterial infections imaging agent (2011)
  • Author(s): Martinez ME, Kiyono Y, Noriki S, Inai K, Mandap KS, Kobayashi M, Mori T, Okazawa H, et al.
  • Journal Title: Nucl Med Biol Volume: 38 Issue: 6 Pages: 807-14
  • DOI: 10.1016/j.nucmedbio.2011.02.006
  • Peer Reviewed
• [Presentation] 病理形態学的なアプローチによる感染症診断分子イメージング剤の開発 (2013)
  • Author(s): 法木左近、稲井邦博、Miguel E Martinez、清野泰
  • Organizer: 第102回日本病理学会
  • Year and Date: 2013-06-07
• [Presentation] New precursor for radiosynthesis of 2-deoxy-2-[18F]fluoroacetamido-D-glucopyranose. (2013)
  • Author(s): M E Martinez, Y Tokunaga, T Mori, S Noriki,K Inai, T Ido, H Okazawa, Y Kiyono.
  • Organizer: The 20th International Symposium on Radiopharmaceutical Sciences
  • Year and Date: 2013-05-12
• [Presentation] 病理形態学的なアプローチによる感染症診断分子イメージング剤の開発 (2013)
  • Author(s): 法木左近
  • Organizer: 第102回日本病理学会
  • Place of Presentation: 札幌
• [Presentation] New precursor for radiosynthesis of 2-deoxy-2-[18F]fluoroacetamido-D-glucopyranose (2013)
  • Author(s): Miguel Martinez
  • Organizer: the 20th International Symposium on Radiopharmaceutical Sciences
  • Place of Presentation: Jeju, Korea
• [Presentation] PETによる深在性真菌症診断のための分子イメージング剤の開発 (2011)
  • Author(s): 法木左近、岩崎博道
  • Organizer: 日本医真菌学会
  • Year and Date: 2011-10-22