| Project/Area Number |
23659221
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | University of Fukui |
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Principal Investigator |
NORIKI Sakon 福井大学, 医学部, 准教授 (30228374)
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| Co-Investigator(Renkei-kenkyūsha) |
INAI Kunihiro 福井大学, 医学部, 助教 (30313745)
KIYONO Yasushi 福井大学, 高エネルギー医学研究センター, 教授 (50305603)
IDO Tatsuo 福井大学, 高エネルギー医学研究センター, 客員教授 (80134063)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 診断 / PET / 感染症 / 分子イメージング / 感染巣 / 画像化 / 抗生物質 / 治療効果 / 合成方法 / FAG |
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| Research Abstract |
We synthesized N-[18F]Fluoroacetyl-D- glucosamine (18F-GlcNAc: FAG), As a molecular imaging agent specifically taken into the fungus and bacteria.We proved that we can specifically image the infection nest in the living body by FAG-PET for the rats with bacterial infection and noninfectious inflammation. Moreover, we confirmed the curative effects of antibiotic by time-dependent changes of FAG-PET images of the infection rat medicated with the antibiotic.Furthermore, I newly compounded two kinds of precursor for FAG synthesis, and have improved yield of FAG
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