Study on immune evasion mechanism by Staphylococcus aureus via immune inhibitory receptors

• Project/Area Number: 23659223
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Bacteriology (including Mycology)
• Research Institution: Osaka University
• Principal Investigator: ARASE Hisashi 大阪大学, 微生物病研究所, 教授 (10261900)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
• Keywords: 黄色ブドウ球菌 / 抑制化レセプター / 免疫逃避 / 病原性

Research Abstract

Host immune response plays an important role in the regulation of bacterial infection. On the other hand, some bacteria seem to have certain immune regulatory mechanism. In the present study, we have analyzed mechanism of immune evasion via inhibitory immune receptors. We found that Staphylococcus aureus expresses a certain ligand for inhibitory PILRα, one of immune inhibitory receptors. Furthermore, we found that there are certain bacteria that express the ligand of activating receptors that have high homology to inhibitory receptors.

Research Products

• [Journal Article] Neutrophil infiltration during inflammation is regulated by PILRalpha via modulation of integrin activation (2012)
  • Author(s): Wang J, et al.
  • Journal Title: Nat Immunol Volume: 14 Issue: 1 Pages: 2019-2025
  • DOI: 10.1038/ni.2456
  • Peer Reviewed
• [Journal Article] Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis. (2012)
  • Author(s): Ihara, S., Kida, H., Arase, H., et. al.
  • Journal Title: Cancer Res. Volume: 72 Issue: 12 Pages: 2990-2999
  • DOI: 10.1158/0008-5472.can-11-4062
  • Peer Reviewed
• [Journal Article] Significant Association of KIR2DL3-HLA-C1 Combination with Cerebral Malaria and Implications for Co-evolution of KIR and HLA. (2012)
  • Author(s): Hirayasu, K., Ohashi, J., Kashiwase, K., Hananantachai, H., Naka, I., Ogawa, A., Takanashi, M., Satake, M., Nakajima, K., Parham, P., Arase, H., Tokunaga, K., Patarapotikul, J., Yabe, T.
  • Journal Title: PLoS Pathog. Volume: 8 Issue: 3 Pages: e1002565-e1002565
  • DOI: 10.1371/journal.ppat.1002565
  • Peer Reviewed
• [Journal Article] The development of colitogenic CD4+ T cells is regulated by IL-7 in collaboration with natural killer cell function in a murine model of colitis (2012)
  • Author(s): Yamaji O, Totsuka T
  • Journal Title: J Immunol Volume: 188 Issue: 6 Pages: 2524-2536
  • DOI: 10.4049/jimmunol.1100371
  • Peer Reviewed
• [Presentation] ペア型レセプターPILR のリガンド認識における糖鎖修飾の機能 (2012)
  • Author(s): 荒瀬尚
  • Organizer: 第12回日本蛋白質科学会年会
  • Place of Presentation: 名古屋国際会議場、(愛知県)(招待講演)
  • Year and Date: 2012-06-21
• [Presentation] 妊娠中の水痘初感染により子宮内胎児死亡に至った 1 例 (2012)
  • Author(s): 谷村憲司、小嶋伸恵、荒瀬尚、山田秀人
  • Organizer: 第27回ヘルペスウイルス研究会
  • Place of Presentation: あいち健康プラザ健康宿泊館プラザホール(愛知県)
  • Year and Date: 2012-06-07
• [Presentation] 水痘帯状疱疹ウイルス(VZV)の膜融合におけるシアル酸の役割 (2012)
  • Author(s): 末永忠広、松本麻紀、有澤 史倫、森康子、荒瀬尚
  • Organizer: 第27回ヘルペスウイルス研究会
  • Place of Presentation: あいち健康プラザ健康宿泊館プラザホール(愛知県)
  • Year and Date: 2012-06-07
• [Presentation] A Varicella-Zoster Virus entry receptor that expresses on hematopoietic cells (2011)
  • Author(s): T.Suenaga, M.Matsumoto, Y.Mori, H.Arase
  • Organizer: 15th International Conference on Immunobiology and Prophylaxis of Human Herpesvirus Infections
  • Place of Presentation: San Servolo,Venice (Italy)
  • Year and Date: 2011-10-13
• [Presentation] Newly Identified Varicella-Zoster Virus (VZV) Entry Receptor Expressed in Hematopoietic Cells (2011)
  • Author(s): Tadahiro Suenaga, Fuminori Arisawa, Yasuko Mori, Hisashi Arase
  • Organizer: International Union of Microbiological Societies Congresses 2011
  • Place of Presentation: 札幌コンベンションセンター(北海道)
  • Year and Date: 2011-09-12
• [Presentation] 水痘帯状疱疹ウイルス(VZV)の膜融合機序の解析 (2011)
  • Author(s): 末永忠広、松本麻紀、森康子、荒瀬尚
  • Organizer: 第26回ヘルペスウイルス研究会
  • Place of Presentation: 大阪アカデミア(大阪府)
  • Year and Date: 2011-06-04
• [Presentation] 水痘帯状疱疹ウイルス(VZV)の膜融合機序の解析 (2011)
  • Author(s): 末永忠広、松本麻紀、森康子、荒瀬尚
  • Organizer: 第26回ヘルペスウイルス研究会
  • Place of Presentation: 大阪市（大阪アカデミア）
• [Presentation] Newly Identified Varicella-Zoster Virus(VZV) Entry Receptor Expressed in Hematopoietic Cells (2011)
  • Author(s): Tadahiro Suenaga, Fuminori Arisawa, Yasuko Mori, Hisashi Arase
  • Organizer: International Union of Microbiological Societies Congresses 2011
  • Place of Presentation: Sapporo (JAPAN)
• [Presentation] A Varicella-Zoster Virus entry receptor that expresses on hematopoietic cells (2011)
  • Author(s): T.Suenaga, M.Matsumoto, Y.Mori, H.Arase
  • Organizer: 15th International Conference on Immunobiology and Prophylaxis of Human Herpesvirus Infections
  • Place of Presentation: San Servolo,Venice,Italy
• [Presentation] 水痘帯状疱疹ウイルス(VZV)の膜融合におけるシアル酸の役割
  • Author(s): 末永忠広、松本麻紀、有澤 史倫、森康子、荒瀬尚
  • Organizer: 第27回ヘルペスウイルス研究会
  • Place of Presentation: あいち健康プラザ健康宿泊館プラザホール（愛知県）
• [Presentation] 妊娠中の水痘初感染により子宮内胎児死亡に至った1例
  • Author(s): 谷村 憲司、小嶋 伸恵、荒瀬 尚、山田 秀人
  • Organizer: 第27回ヘルペスウイルス研究会
  • Place of Presentation: あいち健康プラザ健康宿泊館プラザホール（愛知県）
• [Presentation] ペア型レセプターPILRのリガンド認識における糖鎖修飾の機能
  • Author(s): 荒瀬 尚
  • Organizer: 第12回日本蛋白質科学会年会
  • Place of Presentation: 名古屋国際会議場（愛知県）
  • Invited
• [Remarks]
  • URL: http://immchem.biken.osaka-u.ac.jp/
• [Remarks] 大阪大学微生物病研究所／免疫学フロンティア研究センター 免疫化学分野
  • URL: http://immchem.biken.osaka-u.ac.jp/
• [Remarks]
  • URL: http://immchem.biken.osaka-u.ac.jp/