Study on immune evasion mechanism by Staphylococcus aureus via immune inhibitory receptors
Project/Area Number |
23659223
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Bacteriology (including Mycology)
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Research Institution | Osaka University |
Principal Investigator |
ARASE Hisashi 大阪大学, 微生物病研究所, 教授 (10261900)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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Keywords | 黄色ブドウ球菌 / 抑制化レセプター / 免疫逃避 / 病原性 |
Research Abstract |
Host immune response plays an important role in the regulation of bacterial infection. On the other hand, some bacteria seem to have certain immune regulatory mechanism. In the present study, we have analyzed mechanism of immune evasion via inhibitory immune receptors. We found that Staphylococcus aureus expresses a certain ligand for inhibitory PILRα, one of immune inhibitory receptors. Furthermore, we found that there are certain bacteria that express the ligand of activating receptors that have high homology to inhibitory receptors.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Significant Association of KIR2DL3-HLA-C1 Combination with Cerebral Malaria and Implications for Co-evolution of KIR and HLA.2012
Author(s)
Hirayasu, K., Ohashi, J., Kashiwase, K., Hananantachai, H., Naka, I., Ogawa, A., Takanashi, M., Satake, M., Nakajima, K., Parham, P., Arase, H., Tokunaga, K., Patarapotikul, J., Yabe, T.
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Journal Title
PLoS Pathog.
Volume: 8
Issue: 3
Pages: e1002565-e1002565
DOI
Related Report
Peer Reviewed
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