| Project/Area Number |
23659224
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Nara Medical University |
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Principal Investigator |
MIZUNO Fumiko 奈良県立医科大学, 医学部, 講師 (70271202)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | サルモネラ胃腸炎後脳症 / マウスモデル / L form / 脳内ｻｲﾄｶｲﾝ / L-form / 非チフス性サルモネラ脳症 / サルモネラ脳症 / サルモネラ胃腸炎後 / 非チフス |
|---|
| Research Abstract |
We attempted to make a mouse model for Salmonella encephalopathy after acute Salmonella gastroenteritis. We used Salmonella typhimurium SPI2-(Salmonella pathogenicity island 2 deficiency strain),which colonized at the intestine and rarely translocated to reticuloendothelial system, and used C57BL/6 mice which were susceptible to Salmonella.
Infected mice didn't show neurological signs. In some cases bacillary form of Salmonella was recovered from spleen and liver. In other cases L-form not bacillary form Salmonella was recovered from brain, simultaneously the message of TNF-alpha from brain was expressed and inflammatory cells were accumulated in the cerebral cortex.
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