| Project/Area Number |
23659227
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Virology
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
WAKAI Chitose 筑波大学, 医学医療系, 研究員 (00383662)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 化合物ライブラリー / インフルエンザウイルス / RNA依存RNAポリメラーゼ / In silico解析 / 抗ウイルス薬 / 分子生物学 / ゲノム複製 / 抗ウイルス剤 / in silicoスクリーニング / RNAポリメラーゼ / 変異ウイルス / リバースジェネティクス / RNA依存性RNAポリメラーゼ / In silico 解析 |
|---|
| Research Abstract |
From compound libraries, we tried to isolate the candidate compounds which inhibit the function of influenza virus RNA polymerase and to clarify how they inhibit the polymerase using a chemical biology approach. We screened the libraries containing 3 million compounds by in silico analysis and the inhibitory effect on infection. Finally, we succeeded to isolate candidate compounds and the mutant viruses against them. Now, we are analyzing the function of mutations in more detail.
|
