Quality control of genomes of RNA viruses
| Project/Area Number |
23659228
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITO Masahiko 浜松医科大学, 医学部, 助教 (50385423)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 分子 / 構造 / RNAウイルス / 品質管理 / 国際情報交流 / 米国、欧州諸国 |
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| Research Abstract |
Little is known about quality control of genomes of RNA viruses such as in order to prevent accumulation of nonfunctional viral RNAs in cells. As a first approach to address possible molecular mechanism(s) involved in quality control degradation of viral RNA in virus lifecycles, we searched host cellular proteins that bind the untranslated regions (UTR) of hepatitis C virus RNA genome, and identified PSF, hnRNP-H and p54-nrb as 5’UTR IIId-binding factors. It may be likely that hnRNP-H is involved in the viral RNA stability via its interacting with the viral nucleocapsid protein.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] Trans-complemented hepatitis C virus particles as a versatile tool for study of virus assembly and infection2012
Author(s)
Suzuki R., Saito K., Kato T., Shirakura M., Akazawa D., Ishii K., Aizaki H., Kanegae Y., Matsuura Y., Saito I., Wakita T., and Suzuki T
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Journal Title
Virology
Volume: 432
Pages: 29-38
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[Journal Article] Role of the ERAD pathway in degradation of hepatitis C virus envelope proteins and production of the viral particles.2011
Author(s)
Saeed M, Suzuki R, Watanabe N, Masaki T, Tomonaga M, Muhammad A, Kato T, Matsuura Y, Watanabe H, Wakita T, Suzuki T.
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Journal Title
Journal of Biological Chemistry
Volume: 286
Pages: 37264-37273
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Peer Reviewed
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[Presentation] Identification of lipid droplet-associated membrane proteins that are involved in HCV production2011
Author(s)
Aizaki H, Matsumoto Y, Goto K, Watashi K, Suzuki R, Fukasawa M, Hanada K, Sato S, Takahashi N, Matsuura Y, Motojima K, Miyamura T, Suzuki T, Wakita T.
Organizer
18th International Symposium on Hepatitis C Virus and Related Viruses
Place of Presentation
米国シアトル
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