| Project/Area Number |
23659228
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITO Masahiko 浜松医科大学, 医学部, 助教 (50385423)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 分子 / 構造 / RNAウイルス / 品質管理 / 国際情報交流 / 米国、欧州諸国 |
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| Research Abstract |
Little is known about quality control of genomes of RNA viruses such as in order to prevent accumulation of nonfunctional viral RNAs in cells. As a first approach to address possible molecular mechanism(s) involved in quality control degradation of viral RNA in virus lifecycles, we searched host cellular proteins that bind the untranslated regions (UTR) of hepatitis C virus RNA genome, and identified PSF, hnRNP-H and p54-nrb as 5’UTR IIId-binding factors. It may be likely that hnRNP-H is involved in the viral RNA stability via its interacting with the viral nucleocapsid protein.
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