Analysis of novel host antiviral factors

• Project/Area Number: 23659231
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Virology
• Research Institution: Osaka University
• Principal Investigator: SAITOH Tatsuya 大阪大学, 免疫学フロンティア研究センター, 特任准教授 (60456936)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 感染防御 / 自然免疫 / レトロウイルス / 感染症 / パターン認識受容体 / RNA顆粒 / ウイルス / 感染防御応答 / Ｉ型インターフェロン / RNA

Research Abstract

HIV-1 and MLV are causative agents of AIDS and murine cancer, respectively. Innate immune system protects hosts from infection of HIV-1 and MLV. In the present study, we have demonstrated molecular mechanisms underlying innate immune responses to these retroviruses.

Research Products

• [Journal Article] Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1 (2012)
  • Author(s): Saitoh T, Komano J, Saitoh Y, Misawa T, Takahama M, Kozaki T, Uehata T, Iwasaki H, Omori H, Yamaoka S, Yamamoto N, Akira S
  • Journal Title: Cell Host Microbe Volume: 12 Pages: 109-116
  • Peer Reviewed
• [Journal Article] Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1. (2012)
  • Author(s): Saitoh T, Komano J, Saitoh Y, Misawa T, Takahama M, Kozaki T, Uehata T, Iawasaki H. Omori H, Yamaoka S, Yamamoto N, Akira S.
  • Journal Title: Cell Host Microbe. Volume: 12(1) Issue: 1 Pages: 109-116
  • DOI: 10.1016/j.chom.2012.05.015
  • Peer Reviewed
• [Journal Article] Novel bacterial lipoprotein structures conserved in low-GC content Gram-positive bacteria are recognized by Toll-like receptor 2. (2012)
  • Author(s): Kurokawa K, Ryu KH, Ichikawa R, Masuda A, Kim MS, Lee H, Chae JH, Shimizu T, Saitoh T, Kuwano K, Akira S, Dohmae N, Nakayama H, Lee BL.
  • Journal Title: J Biol Chem. Volume: 287 Pages: 13170-13181
  • Peer Reviewed
• [Journal Article] 自然免疫におけるオートファジーの役割. (2012)
  • Author(s): 齊藤達哉
  • Journal Title: 炎症と免疫 Volume: 20 Pages: 49-54
• [Journal Article] The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1. (2011)
  • Author(s): Iwasaki H, Takeuchi O, Teraguchi S, Matsushita K, Uehata T, Kuniyoshi K, Satoh T, Saitoh T, Matsushita M, Standley DM, Akira S.
  • Journal Title: Nat Immunol. Volume: 12 Pages: 1167-1175
  • Peer Reviewed
• [Journal Article] The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella. (2011)
  • Author(s): Kageyama S, Omori H, Saitoh T, Sone T, Guan JL, Akira S, Imamoto F, Noda T, Yoshimori T.
  • Journal Title: Mol Biol Cell. Volume: 22 Pages: 2290-2300
  • Peer Reviewed
• [Journal Article] オートファジーとインフラマソーム. (2011)
  • Author(s): 齊藤達哉、審良静男.
  • Journal Title: 生体の科学 Volume: 62 Pages: 237-244
• [Journal Article] (*Co-corresponding authors).Zinc-finger antiviral protein mediates RIG-I-like-receptor-independent antiviral response to murine leukemia virus
  • Author(s): Lee H, Komano J, Saitoh Y, Yamaoka S, Kozaki T, Misawa T, Takahama M, Satoh T, Takeuchi O, Yamamoto N, Matsuura Y, Saitoh T*, Akira S*
  • Journal Title: Proc Natl Acad Sci U S A Volume: (in press)
• [Presentation] Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1. (2012)
  • Author(s): Tatsuya Saitoh, Takuma Misawa, Tatsuya Kozaki, Takuya Uehata, Shizuo Akira
  • Organizer: 第41回日本免疫学会総会
  • Place of Presentation: ワークショップ口頭発表、神戸
  • Year and Date: 2012-12-06
• [Presentation] Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1. (2012)
  • Author(s): Saitoh T, et al.
  • Organizer: 第41回日本免疫学会総会
  • Place of Presentation: 神戸
• [Presentation] チューブリン重合阻害剤はNALP3インフラマソームの活性化を抑制する. (2012)
  • Author(s): 齊藤達哉、三澤拓馬、審良静男.
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
• [Presentation] 好中球はNeutrophil extracellular trapsによりHuman immunodeficiency virus-1を排除する. (2011)
  • Author(s): 齊藤達哉、駒野 淳、斎藤 愛記、山岡 昇司、山本 直樹、審良静男.
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] Antiviral Protein Viperin Promotes Lipid Body-Mediated TLR7/9-Induced Production of Type I IFN by Plasmacytoid Dendritic Cells. (2011)
  • Author(s): 齊藤達哉、審良静男.
  • Organizer: 第63回日本細胞生物学会年会
  • Place of Presentation: 札幌
• [Presentation] Identification of a novel antiviral response to HIV-1.
  • Author(s): Saitoh T, Akira S.
  • Organizer: The International Union of Microbiological Societies (IUMS) 2011 Congress
  • Place of Presentation: Sapporo, Japan
• [Remarks]
  • URL: http://hostdefense.ifrec.osaka-u.ac.jp/ja/index.html
• [Remarks] 超高解像イメージング技術を用いて HIV-1 を捕捉・失活させる新たな感染防御機構を同定
  • URL: http://www.ifrec.osaka-u.ac.jp/jpn/research/2012/07/20120723-saito-chm.php