Analysis of novel host antiviral factors
Project/Area Number |
23659231
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Virology
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Research Institution | Osaka University |
Principal Investigator |
SAITOH Tatsuya 大阪大学, 免疫学フロンティア研究センター, 特任准教授 (60456936)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 感染防御 / 自然免疫 / レトロウイルス / 感染症 / パターン認識受容体 / RNA顆粒 / ウイルス / 感染防御応答 / I型インターフェロン / RNA |
Research Abstract |
HIV-1 and MLV are causative agents of AIDS and murine cancer, respectively. Innate immune system protects hosts from infection of HIV-1 and MLV. In the present study, we have demonstrated molecular mechanisms underlying innate immune responses to these retroviruses.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-12012
Author(s)
Saitoh T, Komano J, Saitoh Y, Misawa T, Takahama M, Kozaki T, Uehata T, Iwasaki H, Omori H, Yamaoka S, Yamamoto N, Akira S
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Journal Title
Cell Host Microbe
Volume: 12
Pages: 109-116
Related Report
Peer Reviewed
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[Journal Article] Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1.2012
Author(s)
Saitoh T, Komano J, Saitoh Y, Misawa T, Takahama M, Kozaki T, Uehata T, Iawasaki H. Omori H, Yamaoka S, Yamamoto N, Akira S.
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Journal Title
Cell Host Microbe.
Volume: 12(1)
Issue: 1
Pages: 109-116
DOI
Related Report
Peer Reviewed
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[Journal Article] Novel bacterial lipoprotein structures conserved in low-GC content Gram-positive bacteria are recognized by Toll-like receptor 2.2012
Author(s)
Kurokawa K, Ryu KH, Ichikawa R, Masuda A, Kim MS, Lee H, Chae JH, Shimizu T, Saitoh T, Kuwano K, Akira S, Dohmae N, Nakayama H, Lee BL.
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Journal Title
J Biol Chem.
Volume: 287
Pages: 13170-13181
Related Report
Peer Reviewed
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[Journal Article] The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1.2011
Author(s)
Iwasaki H, Takeuchi O, Teraguchi S, Matsushita K, Uehata T, Kuniyoshi K, Satoh T, Saitoh T, Matsushita M, Standley DM, Akira S.
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Journal Title
Nat Immunol.
Volume: 12
Pages: 1167-1175
Related Report
Peer Reviewed
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[Journal Article] (*Co-corresponding authors).Zinc-finger antiviral protein mediates RIG-I-like-receptor-independent antiviral response to murine leukemia virus
Author(s)
Lee H, Komano J, Saitoh Y, Yamaoka S, Kozaki T, Misawa T, Takahama M, Satoh T, Takeuchi O, Yamamoto N, Matsuura Y, Saitoh T*, Akira S*
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Journal Title
Proc Natl Acad Sci U S A
Volume: (in press)
Related Report
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