• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Investigation of the molecular targets for regulation of HIV-1 expression in latently infected cells

Research Project

Project/Area Number 23659233
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Virology
Research InstitutionKagoshima University

Principal Investigator

BABA Masanori  鹿児島大学, 大学院医歯学総合研究科, 教授 (70181039)

Co-Investigator(Kenkyū-buntansha) OKAMOTO Mika  鹿児島大学, 大学院医歯学総合研究科, 講師 (90336347)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsHIV / 潜伏感染 / 遺伝子発現 / 宿主因子 / 活性化 / HIV-1 / 慢性潜伏感染 / Galectin-3 / TNF-α
Research Abstract

Microarray analysis revealed that 15 cellular factor genes were significantly upregulated along with HIV-1 expression in latently infected cells stimulated with TNF-α. Among the factors, Galectin-3 was found to promote HIV-1 expression through NF-κB activation in the cells.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report

Research Products

(18 results)

All 2013 2012 2011 Other

All Journal Article Presentation Book Remarks Patent(Industrial Property Rights)

  • [Journal Article] Sustained inhibition of HIV-1 replication by conditional expression of the E. coli-derived endoribonuclease MazF in CD4^+ T cells2013

    • Author(s)
      Okamoto M, Chono H, Kawano Y, Saito N, Tsuda H, Inoue K, Kato I, Mineno J, Baba M
    • Journal Title

      Hum. Gene. Ther. Methods

      Volume: 24 Pages: 94-103

    • DOI

      10.1089/hgtb.2012.131

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel inhibitors of human immunodeficiency virus type 1 replication by in silico screening targeting cyclin T1/Tat interaction2013

    • Author(s)
      Takayuki Hamasaki
    • Journal Title

      Antimicrobial agents and chemotherapy

      Volume: 57 Pages: 1323-1331

    • DOI

      10.1128/aac.01711-12

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 抗ウイルス薬の歴史と分類2013

    • Author(s)
      馬場昌範
    • Journal Title

      臨床と微生物

      Volume: 40 Pages: 3-7

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Antihuman immunodeficiency virus type 1 activity of novel 6-substituted 1-benzyl-3-(3,5-dimethylbenzyl)uracil derivatives2012

    • Author(s)
      Paula Ordnnez
    • Journal Title

      Antimicrob. Agents Chemother

      Volume: 56 Pages: 2582-2589

    • DOI

      10.1128/aac.06307-11

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 抗ウイルス薬研究の歴史と進歩2012

    • Author(s)
      馬場昌範
    • Journal Title

      日本臨床

      Volume: 70 Pages: 553-557

    • Related Report
      2012 Annual Research Report
  • [Presentation] Tat依存性のHIV-1産生を抑制する新規低分子化合物の同定2012

    • Author(s)
      濱崎隆之,岡本実佳,馬場昌範
    • Organizer
      第26回日本エイズ学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2012-11-25
    • Related Report
      2012 Final Research Report
  • [Presentation] 核酸系逆転写酵素阻害薬フェスティナビル2011

    • Author(s)
      馬場昌範
    • Organizer
      第25回日本エイズ学会学術集会シンポジウム「次世代の新薬の最新情報」
    • Place of Presentation
      東京
    • Year and Date
      2011-12-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Differential expression of host cellular factors upon HIV-1 reactivation2011

    • Author(s)
      Ordonez-Suarez P, Hamasaki T, Baba M, Okamoto M
    • Organizer
      24th International Conference on Antiviral Research
    • Place of Presentation
      Sofia, Bulgaria
    • Year and Date
      2011-05-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Long-term inhibition of HIV-1 replication in CD4^+ T cells transduced with a retroviral vector conditionally expressing the Escherichia coli endoribonuclease MazF2011

    • Author(s)
      Okamoto M, Chono H, Tsuda H, Inoue K, Mineno J, Baba M
    • Organizer
      24th International Conference on Antiviral Research
    • Place of Presentation
      Sofia, Bulgaria
    • Year and Date
      2011-05-09
    • Related Report
      2012 Final Research Report
  • [Presentation] In silico screening of compounds targeting human cyclin T1 and in vitro evaluation of their anti-HIV-1 activity2011

    • Author(s)
      Hamasaki T, Okamoto M, Baba M
    • Organizer
      24th International Conference on Antiviral Research
    • Place of Presentation
      Sofia, Bulgaria
    • Year and Date
      2011-05-09
    • Related Report
      2012 Final Research Report
  • [Presentation] HIV の活性化における宿主細胞因子の異なった発現2011

    • Author(s)
      オルドネス・スアレス パウラ,濱崎隆之,馬場昌範,岡本実佳
    • Organizer
      第24回国際抗ウイルス会議
    • Place of Presentation
      ソフィア(ブルガリア)
    • Related Report
      2011 Research-status Report
  • [Presentation] 薬剤耐性ウイルスと抗ウイルス薬の開発戦略2011

    • Author(s)
      馬場昌範
    • Organizer
      第21回感染研シンポジウム「病原体と薬剤耐性」(招待講演)
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Book] 抗ウイルス薬の開発.柳 雄介,堤 裕幸(編集)「新編 ウイルスの今日的意味」2012

    • Author(s)
      馬場昌範
    • Publisher
      医薬ジャーナル社
    • Related Report
      2012 Final Research Report
  • [Book] ウイルス病の治療.平松啓一(監修),中込 治,神谷 茂(編集)標準微生物学(第11版)2012

    • Author(s)
      馬場昌範(分担)
    • Publisher
      医学書院
    • Related Report
      2012 Final Research Report
  • [Book] ウイルス感染症の治療.東 臣伸,小熊恵二,堀田 博(編集)シンプル微生物学(第5版)2011

    • Author(s)
      馬場昌範(分担)
    • Publisher
      南江堂
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.kufm.kagoshima-u.ac.jp/~ccvd/

    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 抗ウイルスヌクレオシド類似体およびウイルス感染特にHIV感染の処置方法2012

    • Inventor(s)
      田中博道,馬場昌範,チェン ユン-チ
    • Industrial Property Rights Holder
      エール ユニヴァーシティ,田中博道,馬場昌範
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2012-07-18
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 抗HCV薬2011

    • Inventor(s)
      馬場昌範,モハメド タハ アーメッド サリモ,下茂徹朗,武次祐樹
    • Industrial Property Rights Holder
      国立大学法人鹿児島大学
    • Industrial Property Rights Type
      特許
    • Patent Publication Number
      2012-232955
    • Filing Date
      2011-05-09
    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-04   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi