Role of brain-infiltrating T lymphocytes in the pathogenesis of West Nile virus infection
Project/Area Number |
23659237
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Virology
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Research Institution | National Institute of Infectious Diseases |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
SUZUKI Ryuji 独立行政法人国立病院機構相模原病院臨床研究センター, 室長 (70373470)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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Keywords | ウイルス / 感染症 / 微生物 / 脳神経 / 免疫学 / 脳・神経 |
Research Abstract |
We characterized brain-infiltrating T lymphocytes in mice infected with West Nile virus (WNV). The expression of CD3, CD8, CD69 positively correlated with viral RNA levels. The results suggest that activated Th1-like cytotoxic CD8(+) T cells are expanded in the brains in response to WNV infection. T cell receptor analysis demonstrated that WNV-specific CD3(+)CD8(+) T cells expanding in the infected brains are highly oligoclonal. Further, the infiltrating CD8(+) T cells were WNV-specific, but not cross-reactive to Japanese encephalitis virus.
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Report
(3 results)
Research Products
(5 results)
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[Journal Article] High clonality of virus-specific T lymphocytes defined by TCR usage in the brains of mice infected with West Nile virus.2011
Author(s)
Kitaura, K., Fujii, Y., Hayasaka, D., Matsutani, T., Shirai, K., Nagata, N., Lim, C.K., Suzuki, S., Takasak, T., Suzuki, R. and Kurane, I.
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Journal Title
Journal of Immunology
Volume: 187(8)
Pages: 3919-3930
Related Report
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