In vivo live imaging of T-lymphocyte in the lung and liver
Project/Area Number |
23659240
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Immunology
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Research Institution | Chiba University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
HASEGAWA Akihiro 山口大学, 大学院・医学系研究科, 准教授 (80376376)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 細胞イメージング / 喘息 / リンパ球 |
Research Abstract |
We developed a color-coded in vivo live imaging model to image the cellular dynamics of the migration of Th cells into the lung and liver of living animals, and identify the cellular processes required for the initiation of asthma and acute hepatitis phenotype. Accumulating antigen-specific Th2 cells, but not Th1 cells, formed foci in the lung after antigeninhalation.
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Report
(3 results)
Research Products
(86 results)
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[Journal Article] Murine Schnurri-2 controls Natural Killer cell function and lymphoma development2012
Author(s)
Yamashita, J., Iwamura, C., Mitsumori, K., Hosokawa, H., Sasaki, T., Takahashi, M., Tanaka, H., Kaneko, K., Hanazawa, A., Watanabe, Y., Shinoda, K., Tumes, D., Motohashi, S., Nakayama, T.
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Journal Title
Leuk.Lymphoma
Volume: 53
Issue: 3
Pages: 479-486
DOI
Related Report
Peer Reviewed
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[Journal Article] Type II membrane protein CD69 regulates the formation of resting T-helper memory2012
Author(s)
Shinoda, K., Tokoyoda, K., Hanazawa, A., Hayashizaki, K., Zehentmeier, S., Hosokawa, H., Iwamura, C, Koseki, H., Tumes, D.J., Radbruch, A., Nakayama T.
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Journal Title
Proc.Natl.Acad.Sci.USA
Volume: (in press)
Issue: 19
Pages: 7409-7414
DOI
Related Report
Peer Reviewed
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[Journal Article] The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-・ and suppresses TH2 differentiation2012
Author(s)
Kuwahara, M., Yamashita, M., Shinoda, K., Tofukuji, S., Onodera, A., Shinnakasu, R., Motohashi, S., Hosokawa, H., Tumes, D., Iwamura, C., Lefebvre, V., and Nakayama, T.
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Journal Title
Nat. Immunol
Volume: 13(8)
Issue: 8
Pages: 778-786
DOI
Related Report
Peer Reviewed
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[Journal Article] Regulation of memory CD4 T-cell pool size and function by natural killer T cells in vivo. 109(42) : 16992-16997 (2012).2012
Author(s)
Iwamura, C., Shinoda, K., Endo, Y., Watanabe, Y., Tumes, J. D., Motohashi, S., Kawahara, K., Kinjo, Y., and Nakayama, T.
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 109
Issue: 42
Pages: 16992-16997
DOI
Related Report
Peer Reviewed
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[Journal Article] Apolipoprotein A-II suppressed concanavalin A-induced hepatitis via the inhibition of CD4 T cell function2011
Author(s)
Yamashita, J., Iwamura, C., Sasaki, T., Mitsumori, K., Ohshima, K., Hada, K., Hara, N., Takahashi, M., Kaneshiro, Y., Tanaka, H., Kaneko, K. Nakayama, T
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Journal Title
J. Immunol
Volume: 186
Issue: 6
Pages: 3410-3420
DOI
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Peer Reviewed
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[Journal Article] ncrease of regulatory T cells and the ratio of specific IgE to total IgE are candidates for response monitoring or prognostic biomarkers in 2-year sublingual immunotherapy (SLIT) for Japanese cedar pollinosis2011
Author(s)
Fujimura, T., Yonekura, S., Horiguchi, S., Taniguchi, Y., Saito, A., Yasueda, H., Inamine, A., Nakayama, T., Takemori, T., Taniguchi, M., Sakaguchi, M. Okamoto, Y
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Journal Title
Clin. Immunol
Volume: 139
Issue: 1
Pages: 65-74
DOI
Related Report
Peer Reviewed
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[Journal Article] Repressor of GATA negatively regulates murine contact hypersensitivity through the inhibition of type-2 allergic responses2011
Author(s)
Hirasaki, Y., Iwamura, C., Yamashita, M., Ito, T., Kitajima, M., Shinoda, K., Namiki, T., Terasawa, K. Nakayama, T
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Journal Title
Clin. Immunol
Volume: 139
Issue: 3
Pages: 267-276
DOI
Related Report
Peer Reviewed
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[Journal Article] Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA32011
Author(s)
Horiuchi, S., Onodera, A., Hosokawa, H., Watanabe, Y., Tanaka, T., Sugano, S., SuzukiY. Nakayama, T
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Journal Title
J. Immunol
Volume: 186
Issue: 11
Pages: 6378-6389
DOI
Related Report
Peer Reviewed
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[Journal Article] Memory type 2 helper T cells induce long-lasting anti-tumor immunityby activating natural killer cells2011
Author(s)
Kitajima, M., Ito, T., Tumes, J. D., Endo, Y., Onodera, A., Hashimoto, K., Motohashi, S., Yamashita, M., Nishimura, T., Ziegler, F. S. Nakayama, T
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Journal Title
Cancer Res
Volume: 71
Issue: 14
Pages: 4790-4798
DOI
Related Report
Peer Reviewed
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[Journal Article] Attenuation of lung inflammation and fibrosis in CD69-deficient mice after intratracheal bleomycin2011
Author(s)
Yamauchi, K., Kasuya, Y., Kuroda, F., Tanaka, K., Tsuyusaki, J., Ishizaki, S., Matsunaga, H., Iwamura, C., Nakayama, T. Tatsumi, K
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Journal Title
Respir. Res
Volume: 12
Issue: 1
Pages: 131-131
DOI
Related Report
Peer Reviewed
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[Journal Article] IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation2011
Author(s)
Takahashi, K., Hirose, K., Kawashima, S., Niwa, Y., Wakashin, H., Iwata, A., Tokoyoda, K., Renauland Nakad, J.-C., Iwamoto, I., Nakayama, T. Nakajima, H
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Journal Title
J. Allergy Ciln. Immunol
Volume: 128
Issue: 5
Pages: 1067-1076
DOI
Related Report
Peer Reviewed
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[Journal Article] Cigarette smoke-induced pulmonary inflammation is attenuated in CD69-deficient mice2011
Author(s)
Tsuyusaki, J., Kuroda, F., Kasuya, Y., Ishizaki, I., Yamauchi, K., Sugimoto, H., Kono, T., Iwamura, C., Nakayama, T., Tatsumi, K.
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Journal Title
J.Recept.Sig.Transduct.Res.
Volume: 31
Issue: 6
Pages: 434-439
DOI
Related Report
Peer Reviewed
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[Journal Article] Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA32011
Author(s)
Endo, Y., Iwamura, C., Kuwahara, M., Suzuki, A., Sugaya, K., Tumes, J. D., Tokoyoda, K. Hosokawa, H., Yamashita, M. Nakayama, T
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Journal Title
Immunity
Volume: 35
Issue: 5
Pages: 733-745
DOI
Related Report
Peer Reviewed
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[Presentation] Epigenetic regulation ofhelper T cells by Polycomb and Trithoraxcomplexes2013
Author(s)
Onodera, A., Horiuchi, S., Sasaki, T.,Hosokawa, H., Watanabe, Y., Suzuki, Y., and Nakayama, T.
Organizer
International Symposium onGenome Science
Place of Presentation
Tokyo
Year and Date
2013-01-09
Related Report
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[Presentation] Involvement of invariant Natural Killer Tcells in the acute wound healing in skin2012
Author(s)
Tanno, H., Kanno, E., Ishii, K., Nakayama,T., Taniguchi, M., and Kawakami, K.
Organizer
第41回日本免疫学会学術集会
Place of Presentation
神戸
Year and Date
2012-12-07
Related Report
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[Presentation] Regulation of memory CD4T cell pool size and function by NKT cells in vivo2012
Author(s)
Iwamura, C., Endo, Y., Onodera, A.,Watanabe, Y., Suzuki, A., Kinjo, Y., andNakayama, T.
Organizer
第41回日本免疫学会学術集会
Place of Presentation
神戸 (P)
Year and Date
2012-12-06
Related Report
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[Presentation] CD69 controls a balance between S1P-and CXCL16-induced chemotaxes during the process of memory CD8 T cell recruitmentto the lung airways2012
Author(s)
Takamura, S., Kohlmeier, E. J., Yagi, H., Nakayama, T., Tomura, M., Matsushima, K., Woodland, L. D., and Miyazawa, M.
Organizer
第41回日本免疫学 会学術集会
Place of Presentation
神戸
Year and Date
2012-12-06
Related Report
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[Presentation] CD69 regulates theformation of resting T-helper memory2012
Author(s)
Shinoda, K., Tokoyoda, K., Hanazawa, A., Hayashizaki, K., Hosokawa, H., Iwamura,C., Koseki, H., Tumes, D., Radbruch, A., and Nakayama, T.
Organizer
第41回日本免疫学会学術集会
Place of Presentation
神戸
Year and Date
2012-12-06
Related Report
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[Presentation] SH-2251 inhibits the differentiation of IL-5-producing Th2 cellsthrough repression of Gfi1 induction2012
Author(s)
Suzuki, J., Kuwahara, M., Ohara, O., Nakayama, T., Imamura, M., Kato, F., and Yamashita, M.
Organizer
第41回日本免疫学会学術集会
Place of Presentation
神戸
Year and Date
2012-12-05
Related Report
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[Presentation] Genome-wide gene expression profiling revealed a critical role for GATA3 in the maintenance of the Th2cell phenotype2012
Author(s)
Sasaki, T., Onodera, A., Hosokawa, H., Watanabe, Y., Horiuchi, S., Yamashita, J., and Nakayama, T.
Organizer
第41回日本免疫学会学 術集会
Place of Presentation
神戸
Year and Date
2012-12-05
Related Report
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[Presentation] CD69 controls a balance between S1P- and CXCL16-induced chemotaxes during the process of memory CD8^+ T cell recruitment to the lung airways2012
Author(s)
Takamura, S., Kohlmeier, E. J., Yagi, H., Nakayama, T., Tomura, M., Matsushima, K., Woodland, L. D., and Miyazawa, M.
Organizer
THE 34th NAITO CONFERENCE ON Infection, Immunity, and their control for Health.
Place of Presentation
Sapporo
Year and Date
2012-10-18
Related Report
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[Presentation] CD69regulates the formation of resting T-helpermemory2012
Author(s)
Shinoda, K., Tokoyoda, K., Hanazawa, A., Hayashizaki, K., and Nakayama, T.
Organizer
THE 34th NAITO CONFERENCE ON Infection, Immunity,and their control for Health.
Place of Presentation
Sapporo
Year and Date
2012-10-18
Related Report
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[Presentation] 好酸球性慢性鼻副鼻腔炎に伴う鼻茸の病理学的形成機序の解明 / Pathological mechanism of eosinophilic chronic rhinosinusitis withnasal polyps2011
Author(s)
Iinuma, T., Inamine, A., Sakurai, T., Sakurai, D., Yamamoto, H., Nakayama, T., and Okamoto, Y.
Organizer
第40回日本免疫学会学術集会
Place of Presentation
幕張
Year and Date
2011-11-29
Related Report
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[Presentation] メモリーTh2細胞は NK 細胞を活性化し抗腫瘍効果を持続させる/Memory type 2 helper T cells induce long-lasting anti-tumor immunity byactivating natural killer cells2011
Author(s)
Ito, T., Kitajima, M., Tumes, J. D., Endo, Y., Onodera, A., Hashimoto, K., Motohashi, S., Yamashita, M., Nishimura, T., andNakayama, T.
Organizer
第40回日本免疫学会学術集会
Place of Presentation
幕張
Year and Date
2011-11-28
Related Report
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[Presentation] STAT6 によって誘導されるポリコームとトライソラックスの置換反応/STAT6-mediated displacement of Polycomb by Trithorax complex establishes long-term maintenance ofGATA3 expression in Th2 cells2011
Author(s)
Onodera, A., Yamashita, M., Endo, Y., Kuwahara, M., Tofukuji, S., Hosokawa, H., Horiuchi, S., Watanabe, Y., and Nakayama,T.
Organizer
第40回日本免疫学会学術集会
Place of Presentation
幕張
Year and Date
2011-11-27
Related Report
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[Presentation] STAT6によって誘導されるポリコ-ムとトライソラックスの置換反応/ STAT6-mediated displacement of Polycomb by Trithorax complex establishes long-term maintenance of GATA3 expression in Th2 cells.2011
Author(s)
Onodera, A., Yamashita, M., Endo, Y., Kuwahara, M., Tofukuji, S., Hosokawa, H., Horiuchi, S., Watanabe, Y. and Nakayama, T.
Organizer
第40回日本免疫学会学術集会
Place of Presentation
幕張
Related Report
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[Presentation] メモリ-Th2細胞はNK細胞を活性化し抗腫瘍効果を持続させる/ Memory type 2 helper T cells induce long-lasting anti-tumor immunity by activating natural killer cells.2011
Author(s)
Ito, T., Kitajima, M., Tumes, J. D., Endo, Y., Onodera, A., Hashimoto, K., Motohashi, S., Yamashita, M., Nishimura, T. and Nakayama, T.
Organizer
第40回日本免疫学会学術集会
Place of Presentation
幕張
Related Report
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[Presentation] 好酸球性慢性鼻副鼻腔炎に伴う鼻茸の病理学的形成機序の解明/ Pathological mechanism of eosinophilic chronic rhinosinusitis with nasal polyps.2011
Author(s)
Iinuma, T., Inamine, A., Sakurai, T., Sakurai, D., Yamamoto, H., Nakayama, T. and Okamoto, Y
Organizer
第40回日本免疫学会学術集会
Place of Presentation
幕張
Related Report
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[Presentation] CD69 regulates the formation of resting T-helper memory
Author(s)
Shinoda, K., Tokoyoda, K., Hanazawa, A., Hayashizaki, K., and Nakayama, T.
Organizer
THE 34th NAITO CONFERENCE ON Infection, Immunity, and their control for Health
Place of Presentation
札幌
Related Report
-
[Presentation] CD69 controls a balance between S1P- and CXCL16-induced chemotaxes during the process of memory CD8+ T cell recruitment to the lung airways
Author(s)
Takamura, S., Kohlmeier, E. J., Yagi, H., Nakayama, T., Tomura, M., Matsushima, K., Woodland, L. D., and Miyazawa, M.
Organizer
THE 34th NAITO CONFERENCE ON Infection, Immunity, and their control for Health
Place of Presentation
札幌
Related Report
-
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[Presentation] Genome-wide gene expression profiling revealed a critical role for GATA3 in the maintenance of the Th2 cell phenotype
Author(s)
Sasaki, T., Onodera, A., Hosokawa, H., Watanabe, Y., Horiuchi, S., Yamashita, J., and Nakayama, T.
Organizer
第41回日本免疫学会学術集会
Place of Presentation
神戸
Related Report
-
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[Presentation] SH-2251 inhibits the differentiation of IL-5-producing Th2 cells through repression of Gfi1 induction
Author(s)
Suzuki, J., Kuwahara, M., Ohara, O., Nakayama, T., Imamura, M., Kato, F., and Yamashita, M.
Organizer
第41回日本免疫学会学術集会
Place of Presentation
神戸
Related Report
-
[Presentation] CD69 regulates the formation of resting T-helper memory
Author(s)
Shinoda, K., Tokoyoda, K., Hanazawa, A., Hayashizaki, K., Hosokawa, H., Iwamura, C., Koseki, H., Tumes, D., Radbruch, A., and Nakayama, T.
Organizer
第41回日本免疫学会学術集会
Place of Presentation
神戸
Related Report
-
[Presentation] CD69 controls a balance between S1P-and CXCL16-induced chemotaxes during the process of memory CD8 T cell recruitment to the lung airways
Author(s)
Takamura, S., Kohlmeier, E. J., Yagi, H., Nakayama, T., Tomura, M., Matsushima, K., Woodland, L. D., and Miyazawa, M.
Organizer
第41回日本免疫学会学術集会
Place of Presentation
神戸
Related Report
-
[Presentation] Regulation of memory CD4 T cell pool size and function by NKT cells in vivo
Author(s)
Iwamura, C., Endo, Y., Onodera, A., Watanabe, Y., Suzuki, A., Kinjo, Y., and Nakayama, T.
Organizer
第41回日本免疫学会学術集会
Place of Presentation
神戸
Related Report
-
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[Presentation] Involvement of invariant Natural Killer T cells in the acute wound healing in skin
Author(s)
Tanno, H., Kanno, E., Ishii, K., Nakayama, T., Taniguchi, M., and Kawakami, K.
Organizer
第41回日本免疫学会学術集会
Place of Presentation
神戸
Related Report
-
[Presentation] Epigenetic regulation of helper T cells by Polycomb and Trithorax complexes
Author(s)
Onodera, A., Horiuchi, S., Sasaki, T., Hosokawa, H., Watanabe, Y., Suzuki, Y., and Nakayama, T.
Organizer
International Symposium on Genome Science 2013
Place of Presentation
東京
Related Report
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[Patent(Industrial Property Rights)] 関節リウマチに対する抗IL-6受 容体抗体療法の有効性の予測方法2011
Inventor(s)
中島裕史(国立大学法人千葉大学大学院)、池田 啓(国立大学法人千葉大学大学院)、加々美新一郎(国立大学法人千葉大学大学院)、鈴木快枝(国立大学法人千葉大学大学院)、中山俊憲(国立大学法人千葉大学大学院)、岩本逸夫*、古田俊介*、小原收(財団法人かずさディー・エヌ・エー研究所)、野中 謙*、山下政克(財団法人かずさディー・エヌ・エー研究所)、的場亮*
Industrial Property Rights Holder
国立大学法人千葉大学、財団法人かずさディー・エヌ・エー研究所*
Industrial Property Number
2011-156921
Filing Date
2011-07-15
Related Report
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