In vivo live imaging of T-lymphocyte in the lung and liver

• Project/Area Number: 23659240
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Chiba University
• Principal Investigator: NAKAYAMA Toshinori 千葉大学, 大学院・医学研究院, 教授 (50237468)
• Co-Investigator(Kenkyū-buntansha): HASEGAWA Akihiro 山口大学, 大学院・医学系研究科, 准教授 (80376376)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 細胞イメージング / 喘息 / リンパ球

Research Abstract

We developed a color-coded in vivo live imaging model to image the cellular dynamics of the migration of Th cells into the lung and liver of living animals, and identify the cellular processes required for the initiation of asthma and acute hepatitis phenotype. Accumulating antigen-specific Th2 cells, but not Th1 cells, formed foci in the lung after antigeninhalation.

Research Products

• [Journal Article] Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity. (2013)
  • Author(s): Hosokawa H
  • Journal Title: Proc Natl Acad Sci U SA Volume: - Issue: 12 Pages: 4691-4696
  • DOI: 10.1073/pnas.1220865110
  • Peer Reviewed
• [Journal Article] Murine Schnurri-2 controls Natural Killer cell function and lymphoma development (2012)
  • Author(s): Yamashita, J., Iwamura, C., Mitsumori, K., Hosokawa, H., Sasaki, T., Takahashi, M., Tanaka, H., Kaneko, K., Hanazawa, A., Watanabe, Y., Shinoda, K., Tumes, D., Motohashi, S., Nakayama, T.
  • Journal Title: Leuk.Lymphoma Volume: 53 Issue: 3 Pages: 479-486
  • DOI: 10.3109/10428194.2011.625099
  • Peer Reviewed
• [Journal Article] Type II membrane protein CD69 regulates the formation of resting T-helper memory (2012)
  • Author(s): Shinoda, K., Tokoyoda, K., Hanazawa, A., Hayashizaki, K., Zehentmeier, S., Hosokawa, H., Iwamura, C, Koseki, H., Tumes, D.J., Radbruch, A., Nakayama T.
  • Journal Title: Proc.Natl.Acad.Sci.USA Volume: (in press) Issue: 19 Pages: 7409-7414
  • DOI: 10.1073/pnas.1118539109
  • Peer Reviewed
• [Journal Article] The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-・ and suppresses TH2 differentiation (2012)
  • Author(s): Kuwahara, M., Yamashita, M., Shinoda, K., Tofukuji, S., Onodera, A., Shinnakasu, R., Motohashi, S., Hosokawa, H., Tumes, D., Iwamura, C., Lefebvre, V., and Nakayama, T.
  • Journal Title: Nat. Immunol Volume: 13(8) Issue: 8 Pages: 778-786
  • DOI: 10.1038/ni.2362
  • Peer Reviewed
• [Journal Article] Regulation of memory CD4 T-cell pool size and function by natural killer T cells in vivo. 109(42) : 16992-16997 (2012). (2012)
  • Author(s): Iwamura, C., Shinoda, K., Endo, Y., Watanabe, Y., Tumes, J. D., Motohashi, S., Kawahara, K., Kinjo, Y., and Nakayama, T.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 109 Issue: 42 Pages: 16992-16997
  • DOI: 10.1073/pnas.1203494109
  • Peer Reviewed
• [Journal Article] Apolipoprotein A-II suppressed concanavalin A-induced hepatitis via the inhibition of CD4 T cell function (2011)
  • Author(s): Yamashita, J., Iwamura, C., Sasaki, T., Mitsumori, K., Ohshima, K., Hada, K., Hara, N., Takahashi, M., Kaneshiro, Y., Tanaka, H., Kaneko, K. Nakayama, T
  • Journal Title: J. Immunol Volume: 186 Issue: 6 Pages: 3410-3420
  • DOI: 10.4049/jimmunol.1002924
  • Peer Reviewed
• [Journal Article] ncrease of regulatory T cells and the ratio of specific IgE to total IgE are candidates for response monitoring or prognostic biomarkers in 2-year sublingual immunotherapy (SLIT) for Japanese cedar pollinosis (2011)
  • Author(s): Fujimura, T., Yonekura, S., Horiguchi, S., Taniguchi, Y., Saito, A., Yasueda, H., Inamine, A., Nakayama, T., Takemori, T., Taniguchi, M., Sakaguchi, M. Okamoto, Y
  • Journal Title: Clin. Immunol Volume: 139 Issue: 1 Pages: 65-74
  • DOI: 10.1016/j.clim.2010.12.022
  • Peer Reviewed
• [Journal Article] Repressor of GATA negatively regulates murine contact hypersensitivity through the inhibition of type-2 allergic responses (2011)
  • Author(s): Hirasaki, Y., Iwamura, C., Yamashita, M., Ito, T., Kitajima, M., Shinoda, K., Namiki, T., Terasawa, K. Nakayama, T
  • Journal Title: Clin. Immunol Volume: 139 Issue: 3 Pages: 267-276
  • DOI: 10.1016/j.clim.2011.02.009
  • Peer Reviewed
• [Journal Article] TSLP enhances the function of helper type2 cells. Eur (2011)
  • Author(s): Kitajima, M., Lee, H.-C., Nakayama, T. Ziegler, S. F
  • Journal Title: J. Immunol Volume: 41 Issue: 7 Pages: 1862-1870
  • DOI: 10.1002/eji.201041195
  • Peer Reviewed
• [Journal Article] Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3 (2011)
  • Author(s): Horiuchi, S., Onodera, A., Hosokawa, H., Watanabe, Y., Tanaka, T., Sugano, S., SuzukiY. Nakayama, T
  • Journal Title: J. Immunol Volume: 186 Issue: 11 Pages: 6378-6389
  • DOI: 10.4049/jimmunol.1100179
  • Peer Reviewed
• [Journal Article] Memory type 2 helper T cells induce long-lasting anti-tumor immunityby activating natural killer cells (2011)
  • Author(s): Kitajima, M., Ito, T., Tumes, J. D., Endo, Y., Onodera, A., Hashimoto, K., Motohashi, S., Yamashita, M., Nishimura, T., Ziegler, F. S. Nakayama, T
  • Journal Title: Cancer Res Volume: 71 Issue: 14 Pages: 4790-4798
  • DOI: 10.1158/0008-5472.can-10-1572
  • Peer Reviewed
• [Journal Article] Attenuation of lung inflammation and fibrosis in CD69-deficient mice after intratracheal bleomycin (2011)
  • Author(s): Yamauchi, K., Kasuya, Y., Kuroda, F., Tanaka, K., Tsuyusaki, J., Ishizaki, S., Matsunaga, H., Iwamura, C., Nakayama, T. Tatsumi, K
  • Journal Title: Respir. Res Volume: 12 Issue: 1 Pages: 131-131
  • DOI: 10.1186/1465-9921-12-131
  • Peer Reviewed
• [Journal Article] IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation (2011)
  • Author(s): Takahashi, K., Hirose, K., Kawashima, S., Niwa, Y., Wakashin, H., Iwata, A., Tokoyoda, K., Renauland Nakad, J.-C., Iwamoto, I., Nakayama, T. Nakajima, H
  • Journal Title: J. Allergy Ciln. Immunol Volume: 128 Issue: 5 Pages: 1067-1076
  • DOI: 10.1016/j.jaci.2011.06.018
  • Peer Reviewed
• [Journal Article] Cigarette smoke-induced pulmonary inflammation is attenuated in CD69-deficient mice (2011)
  • Author(s): Tsuyusaki, J., Kuroda, F., Kasuya, Y., Ishizaki, I., Yamauchi, K., Sugimoto, H., Kono, T., Iwamura, C., Nakayama, T., Tatsumi, K.
  • Journal Title: J.Recept.Sig.Transduct.Res. Volume: 31 Issue: 6 Pages: 434-439
  • DOI: 10.3109/10799893.2011.631929
  • Peer Reviewed
• [Journal Article] Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3 (2011)
  • Author(s): Endo, Y., Iwamura, C., Kuwahara, M., Suzuki, A., Sugaya, K., Tumes, J. D., Tokoyoda, K. Hosokawa, H., Yamashita, M. Nakayama, T
  • Journal Title: Immunity Volume: 35 Issue: 5 Pages: 733-745
  • DOI: 10.1016/j.immuni.2011.08.017
  • Peer Reviewed
• [Presentation] Epigenetic regulation ofhelper T cells by Polycomb and Trithoraxcomplexes (2013)
  • Author(s): Onodera, A., Horiuchi, S., Sasaki, T.,Hosokawa, H., Watanabe, Y., Suzuki, Y., and Nakayama, T.
  • Organizer: International Symposium onGenome Science
  • Place of Presentation: Tokyo
  • Year and Date: 2013-01-09
• [Presentation] Involvement of invariant Natural Killer Tcells in the acute wound healing in skin (2012)
  • Author(s): Tanno, H., Kanno, E., Ishii, K., Nakayama,T., Taniguchi, M., and Kawakami, K.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-07
• [Presentation] Enhanced function of primary human T cells electroporated with RNA for LAT that is resistant toubiquitylation (2012)
  • Author(s): Kunii, N., Motohashi, S., Okamoto, Y., and Nakayama, T.
  • Organizer: 第41回日本免疫学会学 術集会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-06
• [Presentation] Regulation of memory CD4T cell pool size and function by NKT cells in vivo (2012)
  • Author(s): Iwamura, C., Endo, Y., Onodera, A.,Watanabe, Y., Suzuki, A., Kinjo, Y., andNakayama, T.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸 (P)
  • Year and Date: 2012-12-06
• [Presentation] CD69 controls a balance between S1P-and CXCL16-induced chemotaxes during the process of memory CD8 T cell recruitmentto the lung airways (2012)
  • Author(s): Takamura, S., Kohlmeier, E. J., Yagi, H., Nakayama, T., Tomura, M., Matsushima, K., Woodland, L. D., and Miyazawa, M.
  • Organizer: 第41回日本免疫学 会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-06
• [Presentation] CD69 regulates theformation of resting T-helper memory (2012)
  • Author(s): Shinoda, K., Tokoyoda, K., Hanazawa, A., Hayashizaki, K., Hosokawa, H., Iwamura,C., Koseki, H., Tumes, D., Radbruch, A., and Nakayama, T.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-06
• [Presentation] SH-2251 inhibits the differentiation of IL-5-producing Th2 cellsthrough repression of Gfi1 induction (2012)
  • Author(s): Suzuki, J., Kuwahara, M., Ohara, O., Nakayama, T., Imamura, M., Kato, F., and Yamashita, M.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-05
• [Presentation] Menin-Bach2 axis controls senescence-associated secretory phenotype(SASP) in CD4 T cells (2012)
  • Author(s): Kuwahara, M., Suzuki, J., Ohara, O., Nakayama, T., and Yamashita, M.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-05
• [Presentation] Genome-wide gene expression profiling revealed a critical role for GATA3 in the maintenance of the Th2cell phenotype (2012)
  • Author(s): Sasaki, T., Onodera, A., Hosokawa, H., Watanabe, Y., Horiuchi, S., Yamashita, J., and Nakayama, T.
  • Organizer: 第41回日本免疫学会学 術集会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-05
• [Presentation] α-Gal Cer-Ag DC の口腔粘膜下投与におけるアレルギー性鼻炎炎症の抑制機序の解明 (2012)
  • Author(s): 櫻井利興、稲嶺絢子、櫻井大樹、飯沼智久、石井保之、中山俊憲、岡本美孝
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2012-12-01
• [Presentation] 好酸球性副鼻腔炎における IL-25 と Th2, Th9の関与 (2012)
  • Author(s): 飯沼智久、山本陛三朗、稲嶺絢子、大木雄示、櫻井利興、米倉修二、櫻井大樹、中山俊憲、岡本美孝
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2012-11-29
• [Presentation] CD69 controls a balance between S1P- and CXCL16-induced chemotaxes during the process of memory CD8^+ T cell recruitment to the lung airways (2012)
  • Author(s): Takamura, S., Kohlmeier, E. J., Yagi, H., Nakayama, T., Tomura, M., Matsushima, K., Woodland, L. D., and Miyazawa, M.
  • Organizer: THE 34th NAITO CONFERENCE ON Infection, Immunity, and their control for Health.
  • Place of Presentation: Sapporo
  • Year and Date: 2012-10-18
• [Presentation] CD69regulates the formation of resting T-helpermemory (2012)
  • Author(s): Shinoda, K., Tokoyoda, K., Hanazawa, A., Hayashizaki, K., and Nakayama, T.
  • Organizer: THE 34th NAITO CONFERENCE ON Infection, Immunity,and their control for Health.
  • Place of Presentation: Sapporo
  • Year and Date: 2012-10-18
• [Presentation] マウス Schnurri-2 は NK 細胞の機能とリンパ腫の発症を制御する (2012)
  • Author(s): 伊藤俊広、三森国敏、本橋新一郎、中山 憲
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-19
• [Presentation] 原発 性肺癌に対する NKT 細胞免疫治療後の 腫瘍局所における免疫応答の解析 (2012)
  • Author(s): 本橋新一郎、石橋史博、長門芳、國井直樹、谷口克、吉野一郎、中山俊憲
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-19
• [Presentation] ユビキチン化抵抗性 LAT による T細胞の機能増強 (2012)
  • Author(s): 國井直樹、本橋新一郎、岡本美孝、中山俊憲
  • Organizer: 第71回日本癌学会学 術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-19
• [Presentation] GATA3/Ruvbl2複合体による Cdkn2c (p18, Ink4c)の転 写制御を介した Th2 細胞増殖制御メカニズムの解析 (2012)
  • Author(s): 細川裕之、田中知明、加藤美紀、遠山裕之、鈴木茜、中山俊憲
  • Organizer: 第22回 Kyoto T cell Conference
  • Place of Presentation: 京都
  • Year and Date: 2012-07-06
• [Presentation] 好酸球性副鼻腔炎のポリープに浸潤するリンパ球の機能解析 (2012)
  • Author(s): 飯沼智久、稲嶺絢子、櫻井利興、船越うらら、山本陛三朗、米倉修二、櫻井大樹、中山俊憲、岡本美孝
  • Organizer: 第24回日本アレルギー学会春季臨床大会
  • Place of Presentation: 大阪
  • Year and Date: 2012-05-13
• [Presentation] 免疫記憶を利用した難治性喘息と肺癌の新規免疫治療法開発のトランスレーショナルリサーチ特別講演BIO tech 2012 (2012)
  • Author(s): 中山俊憲
  • Organizer: 第11回国際バイオテクノロジー展/技術会議
  • Place of Presentation: 東京
  • Year and Date: 2012-04-25
• [Presentation] Real-time cellular imaging of T lymphocyte accumulation in a mouseasthma model. 喘息肺での浸潤リンパ球のリアルタイムイメージング (2012)
  • Author(s): Hasegawa, A., Shirai, M., and Nakayama, T.
  • Organizer: 第85回 日本細菌学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2012-03-28
• [Presentation] Endocytosis mechanism is regulated by the exocyst complex subunit in antigen presenting cells (2012)
  • Author(s): Hashimoto, K., Takahashi, K., Matsunaga, S., and Nakayama, T.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] Real-time cellular imaging of T lymphocyte accumulation in a mouse asthma model. 喘息肺での浸潤リンパ球のリアルタイムイメージング 第85回日本細菌学会総会 (2012)
  • Author(s): Hasegawa, A., Shirai, M. and Nakayama, T.
  • Organizer: 第85回日本細菌学会総会
  • Place of Presentation: 長崎
• [Presentation] 好酸球性慢性鼻副鼻腔炎に伴う鼻茸の病理学的形成機序の解明 / Pathological mechanism of eosinophilic chronic rhinosinusitis withnasal polyps (2011)
  • Author(s): Iinuma, T., Inamine, A., Sakurai, T., Sakurai, D., Yamamoto, H., Nakayama, T., and Okamoto, Y.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-29
• [Presentation] 腸炎の 発症における CD69 分子の役割/ Crucialrole for CD69 in the pathogenesis of DSS-induced colitis (2011)
  • Author(s): Hasegawa, A., and Nakayama, T.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] 活性化 NKT 細胞によるメモリーTh2細胞の増加と機能変化/Selective expansion and functional modulation of memory Th2 cells by activated NKT cellsin vivo (2011)
  • Author(s): 岩村千秋、篠田健太、高橋克己、中山俊憲
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] メモリーTh2細胞は NK 細胞を活性化し抗腫瘍効果を持続させる/Memory type 2 helper T cells induce long-lasting anti-tumor immunity byactivating natural killer cells (2011)
  • Author(s): Ito, T., Kitajima, M., Tumes, J. D., Endo, Y., Onodera, A., Hashimoto, K., Motohashi, S., Yamashita, M., Nishimura, T., andNakayama, T.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] STAT6 によって誘導されるポリコームとトライソラックスの置換反応/STAT6-mediated displacement of Polycomb by Trithorax complex establishes long-term maintenance ofGATA3 expression in Th2 cells (2011)
  • Author(s): Onodera, A., Yamashita, M., Endo, Y., Kuwahara, M., Tofukuji, S., Hosokawa, H., Horiuchi, S., Watanabe, Y., and Nakayama,T.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] IL-22は気道上皮細胞によるIL-25産生を抑制し、アレルギー性気道炎症を制御する (2011)
  • Author(s): 高橋健太郎、廣瀬晃一、川島沙紀、丹羽祐輔、若新英史、岩田有史、小林芳久、常世田好司、中山俊憲、谷口正実、秋山一男
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-11
• [Presentation] α-GalCer-Ag DCの口腔粘膜下投与におけるアレルギー性鼻炎炎症の抑制機序の解明 (2011)
  • Author(s): 櫻井利興、稲嶺絢子、櫻井大樹、飯沼智久、米倉修二、石井保之、中山俊憲 、岡本美孝
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-11
• [Presentation] NKT cell-mediated regulation of antigen-specific memory Th2 cell function (2011)
  • Author(s): Nakayama, T., and Iwamura, C.
  • Organizer: 6thInternational Symposium on CD1 and NKT Cells
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-09-25
• [Presentation] Epigenetic regulation of GATA3 expression and its target genes in Th2 cells (2011)
  • Author(s): Nakayama, T.
  • Organizer: 45^<th> Joint Working Conference on Immunology and Viral Diseases
  • Place of Presentation: CA, USA
  • Year and Date: 2011-06-20
• [Presentation] Regulationof memory Th2 cell function and allergic airway inflammation via polycomb and trithorax molecules (2011)
  • Author(s): Nakayama, T., and Onodera, A.
  • Organizer: 30^<th> Congress of the European Academy of Allergy and Clinical Immunology
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2011-06-15
• [Presentation] Selective expansion and functionalmodulation of memory Th2 cells by activated NKT cells in vivo (2011)
  • Author(s): 岩村千秋、篠田健太、花澤麻美、中山俊憲
  • Organizer: 第21回 Kyoto T Cell Conference
  • Place of Presentation: 京都
  • Year and Date: 2011-06-11
• [Presentation] Eomesodermin controls IL-5production in memory Th2 cells through the inhibition of GATA3 activity (2011)
  • Author(s): 遠藤裕介、小野寺淳、細川裕之、中山俊憲
  • Organizer: 第21回 Kyoto T Cell Conference
  • Place of Presentation: 京都
  • Year and Date: 2011-06-11
• [Presentation] Epigenetic control of memory Th2 cell function via Polycomb and Trithorax molecules (2011)
  • Author(s): Nakayama, T., and Onodera, A.
  • Organizer: EUThyme-Rolduc Meeting
  • Place of Presentation: Leeuwenhorst, Netherland
  • Year and Date: 2011-05-24
• [Presentation] Epigenetic control of memory Th2 cell function via Polycomb and Trithorax molecules. (2011)
  • Author(s): Nakayama, T., and Onodera, A
  • Organizer: EUThyme-Rolduc Meeting
  • Place of Presentation: Leeuwenhorst, NL
• [Presentation] Eomesodermin controls IL-5 production in memory Th2 cells through the inhibition of GATA3 activity (2011)
  • Author(s): 遠藤裕介、小野寺淳、細川裕之、中山俊憲
  • Organizer: 第21回Kyoto T Cell Conference
  • Place of Presentation: 京都
• [Presentation] Selective expansion and functional modulation of memory Th2 cells by activated NKT cells in vivo (2011)
  • Author(s): 岩村千秋、篠田健太、花澤麻美、中山俊憲
  • Organizer: 第21回Kyoto T Cell Conference
  • Place of Presentation: 京都
• [Presentation] Regulation of memory Th2 cell function and allergic airway inflammation via polycomb and trithorax molecules (2011)
  • Author(s): Nakayama, T. and Onodera, A.
  • Organizer: 30th Congress of the European Academy of Allergy and Clinical Immunology
  • Place of Presentation: Istanbul, Turkey
• [Presentation] Epigenetic regulation of GATA3 expression and its target genes in Th2 cells. (2011)
  • Author(s): Nakayama, T.
  • Organizer: 45th Joint Working Conference on Immunology and Viral Diseases
  • Place of Presentation: CA, USA
• [Presentation] Nakayama, T. and Iwamura, C.NKT cell-mediated regulation of antigen-specific memory Th2 cell function. (2011)
  • Author(s): Nakayama, T. and Iwamura, C.
  • Organizer: 6th International Symposium on CD1 and NKT Cells,
  • Place of Presentation: Chicago,USA
• [Presentation] α-GalCer-Ag DCの口腔粘膜下投与におけるアレルギ－性鼻炎炎症の抑制機序の解明 (2011)
  • Author(s): 櫻井利興、稲嶺絢子、櫻井大樹、飯沼智久、米倉修二、石井保之、中山俊憲、岡本美孝
  • Organizer: 第61回日本アレルギ－学会秋季学術大会
  • Place of Presentation: 東京
• [Presentation] IL-22は気道上皮細胞によるIL-25産生を抑制し、アレルギ－性気道炎症を制御する (2011)
  • Author(s): 高橋健太郎、廣瀬晃一、川島沙紀、丹羽祐輔、若新英史、岩田有史、小林芳久、常世田好司、中山俊憲、谷口正実、秋山一男
  • Organizer: 第61回日本アレルギ－学会秋季学術大会
  • Place of Presentation: 東京
• [Presentation] STAT6によって誘導されるポリコ－ムとトライソラックスの置換反応/ STAT6-mediated displacement of Polycomb by Trithorax complex establishes long-term maintenance of GATA3 expression in Th2 cells. (2011)
  • Author(s): Onodera, A., Yamashita, M., Endo, Y., Kuwahara, M., Tofukuji, S., Hosokawa, H., Horiuchi, S., Watanabe, Y. and Nakayama, T.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
• [Presentation] メモリ－Th2細胞はNK細胞を活性化し抗腫瘍効果を持続させる/ Memory type 2 helper T cells induce long-lasting anti-tumor immunity by activating natural killer cells. (2011)
  • Author(s): Ito, T., Kitajima, M., Tumes, J. D., Endo, Y., Onodera, A., Hashimoto, K., Motohashi, S., Yamashita, M., Nishimura, T. and Nakayama, T.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
• [Presentation] 活性化NKT細胞によるメモリ－Th2細胞の増加と機能変化/ Selective expansion and functional modulation of memory Th2 cells by activated NKT cells in vivo. (2011)
  • Author(s): 岩村千秋、篠田健太、高橋克己、中山俊憲
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
• [Presentation] 腸炎の発症におけるCD69分子の役割/ Crucial role for CD69 in the pathogenesis of DSS-induced colitis. (2011)
  • Author(s): Hasegawa, A. and Nakayama, T.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
• [Presentation] 好酸球性慢性鼻副鼻腔炎に伴う鼻茸の病理学的形成機序の解明/ Pathological mechanism of eosinophilic chronic rhinosinusitis with nasal polyps. (2011)
  • Author(s): Iinuma, T., Inamine, A., Sakurai, T., Sakurai, D., Yamamoto, H., Nakayama, T. and Okamoto, Y
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
• [Presentation] 免疫記憶を利用した難治性喘息と肺癌の新規免疫治療法開発のトランスレ－ショナルリサ－チ
  • Author(s): 中山俊憲
  • Organizer: BIO tech 2012 第11回国際バイオテクノロジ－展/技術会議
  • Place of Presentation: 東京
  • Invited
• [Presentation] 好酸球性副鼻腔炎のポリ－プに浸潤するリンパ球の機能解析
  • Author(s): 飯沼智久、稲嶺絢子、櫻井利興、船越うらら、山本陛三朗、米倉修二、櫻井大樹、中山俊憲、岡本美孝
  • Organizer: 第24回日本アレルギ－学会春季臨床大会
  • Place of Presentation: 大阪
• [Presentation] GATA3/Ruvbl2複合体によるCdkn2c (p18, Ink4c)の転写制御を介したTh2細胞増殖制御メカニズムの解析
  • Author(s): 細川裕之、田中知明、加藤美紀、遠山裕之、鈴木茜、中山俊憲
  • Organizer: 第22回Kyoto T cell Conference
  • Place of Presentation: 京都
• [Presentation] ユビキチン化抵抗性LATによるT細胞の機能増強
  • Author(s): 國井直樹、本橋新一郎、岡本美孝、中山俊憲
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 原発性肺癌に対するNKT細胞免疫治療後の腫瘍局所における免疫応答の解析
  • Author(s): 本橋新一郎、石橋史博、長門芳、國井直樹、谷口克、吉野一郎、中山俊憲
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] マウスSchnurri-2はNK細胞の機能とリンパ腫の発症を制御する
  • Author(s): 伊藤俊広、三森国敏、本橋新一郎、中山俊憲
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] CD69 regulates the formation of resting T-helper memory
  • Author(s): Shinoda, K., Tokoyoda, K., Hanazawa, A., Hayashizaki, K., and Nakayama, T.
  • Organizer: THE 34th NAITO CONFERENCE ON Infection, Immunity, and their control for Health
  • Place of Presentation: 札幌
• [Presentation] CD69 controls a balance between S1P- and CXCL16-induced chemotaxes during the process of memory CD8+ T cell recruitment to the lung airways
  • Author(s): Takamura, S., Kohlmeier, E. J., Yagi, H., Nakayama, T., Tomura, M., Matsushima, K., Woodland, L. D., and Miyazawa, M.
  • Organizer: THE 34th NAITO CONFERENCE ON Infection, Immunity, and their control for Health
  • Place of Presentation: 札幌
• [Presentation] 好酸球性副鼻腔炎におけるIL-25とTh2, Th9の関与
  • Author(s): 飯沼智久、山本陛三朗、稲嶺絢子、大木雄示、櫻井利興、米倉修二、櫻井大樹、中山俊憲、岡本美孝
  • Organizer: 第62回日本アレルギ－学会秋季学術大会
  • Place of Presentation: 大阪
• [Presentation] α-GalCer-Ag DCの口腔粘膜下投与におけるアレルギ－性鼻炎炎症の抑制機序の解明
  • Author(s): 櫻井利興、稲嶺絢子、櫻井大樹、飯沼智久、石井保之、中山俊憲、岡本美孝
  • Organizer: 第62回日本アレルギ－学会秋季学術大会
  • Place of Presentation: 大阪
• [Presentation] Genome-wide gene expression profiling revealed a critical role for GATA3 in the maintenance of the Th2 cell phenotype
  • Author(s): Sasaki, T., Onodera, A., Hosokawa, H., Watanabe, Y., Horiuchi, S., Yamashita, J., and Nakayama, T.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] Menin-Bach2 axis controls senescence-associated secretory phenotype (SASP) in CD4 T cells
  • Author(s): Kuwahara, M., Suzuki, J., Ohara, O., Nakayama, T., and Yamashita, M.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] SH-2251 inhibits the differentiation of IL-5-producing Th2 cells through repression of Gfi1 induction
  • Author(s): Suzuki, J., Kuwahara, M., Ohara, O., Nakayama, T., Imamura, M., Kato, F., and Yamashita, M.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] CD69 regulates the formation of resting T-helper memory
  • Author(s): Shinoda, K., Tokoyoda, K., Hanazawa, A., Hayashizaki, K., Hosokawa, H., Iwamura, C., Koseki, H., Tumes, D., Radbruch, A., and Nakayama, T.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] CD69 controls a balance between S1P-and CXCL16-induced chemotaxes during the process of memory CD8 T cell recruitment to the lung airways
  • Author(s): Takamura, S., Kohlmeier, E. J., Yagi, H., Nakayama, T., Tomura, M., Matsushima, K., Woodland, L. D., and Miyazawa, M.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] Regulation of memory CD4 T cell pool size and function by NKT cells in vivo
  • Author(s): Iwamura, C., Endo, Y., Onodera, A., Watanabe, Y., Suzuki, A., Kinjo, Y., and Nakayama, T.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] Enhanced function of primary human T cells electroporated with RNA for LAT that is resistant to ubiquitylation
  • Author(s): Kunii, N., Motohashi, S., Okamoto, Y., and Nakayama, T.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] Involvement of invariant Natural Killer T cells in the acute wound healing in skin
  • Author(s): Tanno, H., Kanno, E., Ishii, K., Nakayama, T., Taniguchi, M., and Kawakami, K.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] Epigenetic regulation of helper T cells by Polycomb and Trithorax complexes
  • Author(s): Onodera, A., Horiuchi, S., Sasaki, T., Hosokawa, H., Watanabe, Y., Suzuki, Y., and Nakayama, T.
  • Organizer: International Symposium on Genome Science 2013
  • Place of Presentation: 東京
• [Patent(Industrial Property Rights)] 「抗」ヒト CD69 抗体、及びその医薬用途 (2012)
  • Inventor(s): 古城周久、宮越陽、加藤静恵、對比地久美子、速水友紀、中村美紀子(ジーンフロンティア(株))、中山俊憲、岩村千秋(国立大学法人千葉大学)
  • Industrial Property Rights Holder: ジーンフロンティア(株)、国立大学法人千葉大学
  • Industrial Property Number: 2012-098243
  • Filing Date: 2012-04-23
• [Patent(Industrial Property Rights)] ｢抗｣ヒトCD69抗体、及びその医薬用途 (2012)
  • Inventor(s): 古城周久、宮越陽、加藤静恵、中山俊憲､岩村千秋、他3名
  • Industrial Property Rights Holder: 千葉大学、ジーンフロンティア株式会社
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-098243
  • Filing Date: 2012-04-23
• [Patent(Industrial Property Rights)] 関節リウマチに対する抗IL-6受 容体抗体療法の有効性の予測方法 (2011)
  • Inventor(s): 中島裕史(国立大学法人千葉大学大学院)、池田 啓(国立大学法人千葉大学大学院)、加々美新一郎(国立大学法人千葉大学大学院)、鈴木快枝(国立大学法人千葉大学大学院)、中山俊憲(国立大学法人千葉大学大学院)、岩本逸夫*、古田俊介*、小原收(財団法人かずさディー・エヌ・エー研究所)、野中 謙*、山下政克(財団法人かずさディー・エヌ・エー研究所)、的場亮*
  • Industrial Property Rights Holder: 国立大学法人千葉大学、財団法人かずさディー・エヌ・エー研究所*
  • Industrial Property Number: 2011-156921
  • Filing Date: 2011-07-15
• [Patent(Industrial Property Rights)] 関節リウマチに対する抗ＩＬ－６受容体抗体療法の有効性の予測方法 (2011)
  • Inventor(s): 中島裕史、池田啓、加々美新一郎、鈴木快枝、中山俊憲他6名
  • Industrial Property Rights Holder: 千葉大学
  • Filing Date: 2011