Systembiology of T-cell differentiation

• Project/Area Number: 23659242
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Keio University
• Principal Investigator: YOSHIMURA Akihiko 慶應義塾大学, 医学部, 教授 (90182815)
• Co-Investigator(Renkei-kenkyūsha): YAMADA Satoshi 岡山理科大学, 工学部, 教授 (20393506)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: サイトカイン シグナル伝達 / 転写因子 / ヘルパーT細胞 / 抑制性T細胞 / TGF-β / シミュレーション / サイトカイン / 炎症 / アレルギー / 自己免疫疾患 / STAT / TGFβ

Research Abstract

Helper T cells have been thought to play a central role in not only acquired immune responses but also inimmune regulation. Recently, several subsets such as Th17 and iTreg have been discovered in addition toTh1 and Th2. Differentiation of each helper T c

Research Products

• [Journal Article] Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis (2013)
  • Author(s): Sekiya T, Kashiwagi I, Yoshida R, Fukaya T, Morita R, Kimura A, Ichinose H, Metzger D, Chambon P, Yoshimura A
  • Journal Title: Nature Immunol Volume: 14(3) Pages: 230-7
  • Peer Reviewed
• [Journal Article] IL-23-Independent Induction of IL-17 from γδT Cells and Innate Lymphoid Cells Promotes Experimental Intraocular Neovascularization (2013)
  • Author(s): Hasegawa E, Sonoda KH, Shichita T, Morita R, Sekiya T, Kimura A, Oshima Y, Takeda A, Yoshimura T, Yoshida S, Ishibashi T, Yoshimura A
  • Journal Title: J Immunol Volume: 190(4) Pages: 1778-87
  • Peer Reviewed
• [Journal Article] Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis. (2013)
  • Author(s): Sekiya T, Kashiwagi I, Yoshida R, Fukaya T, et al.
  • Journal Title: Nat Immunol. Volume: 14 Issue: 3 Pages: 230-237
  • DOI: 10.1038/ni.2520
  • Peer Reviewed
• [Journal Article] Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain (2012)
  • Author(s): Shichita T, Hasegawa E, Kimura A, MoritaR, Sakaguchi R, Takada I, Sekiya T, Ooboshi H, Kitazono T, Yanagawa T, Ishii T, Takahashi H, Mori S, Nishibori M, Kuroda K, Akira S, Miyake K, and Yoshimura A
  • Journal Title: Nature Medicine Volume: 18(6) Pages: 977-7
  • Peer Reviewed
• [Journal Article] Preferential induction of Th17 cells in vitro and in vivo by Fucogalactan from Ganoderma lucidum (Reishi) (2012)
  • Author(s): Yoshida H, Suzuki M, Sakaguchi R, Tani I, Kotani H, Shudo N, Yoshimura A
  • Journal Title: Biochem Biophys Res Commun Volume: 422(1) Pages: 174-80
  • Peer Reviewed
• [Journal Article] Smad2 and Smad3 are redundantly essential for the suppression of iNOS synthesis in macrophages by regulating IRF3 and STAT1 pathways. (2012)
  • Author(s): Sugiyama Y, Kakoi K, Kimura A, Takada I, Kashiwagi I, Wakabayashi Y, Morita R, Nomura M, Yoshimura A
  • Journal Title: Int Immunol Volume: 24(4) Pages: 253-65
  • Peer Reviewed
• [Journal Article] Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation. (2012)
  • Author(s): Yoshida H, Kimura A, Fukaya T, Sekiya T, Morita R, Shichita T, Inoue H, Yoshimura A
  • Journal Title: Biochem Biophys Res Commun Volume: 418(2) Pages: 234-40
  • Peer Reviewed
• [Journal Article] Forced expression of stabilized c-Fos in dendritic cells reduces cytokine production and immune responses in vivo. (2012)
  • Author(s): Yoshida R
  • Journal Title: Biochem Biophys Res Commun. Volume: 423 Issue: 2 Pages: 247-252
  • DOI: 10.1016/j.bbrc.2012.05.097
  • Peer Reviewed
• [Journal Article] Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain (2012)
  • Author(s): Shichita T
  • Journal Title: Nature Medicine Volume: 18 Issue: 6 Pages: 911-917
  • DOI: 10.1038/nm.2749
  • Peer Reviewed
• [Journal Article] Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17. (2011)
  • Author(s): Nakagawa R, Yoshida H, Asakawa M, Tamiya T, Inoue N, Morita R, Inoue H, Nakao A, Yoshimura A
  • Journal Title: J Immunol Volume: 187(9) Pages: 4611-20
  • Peer Reviewed
• [Journal Article] IL-1β and TNFα-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis. (2011)
  • Author(s): Mori T, Miyamoto T, Yoshida H, Asakawa M, Kawasumi M, Kobayashi T, Morioka H, Chiba K, Toyama Y, Yoshimura A
  • Journal Title: Int Immunol Volume: 23(11) Pages: 701-12
  • Peer Reviewed
• [Journal Article] Histone 3 lysine 9 (H3K methyltransferase recruitment to the interleukin-2 (IL- promoter is a mechanism of suppression of IL-2 transcription by the transforming growth factor-β-Smad pathway. (2011)
  • Author(s): Wakabayashi Y, Tamiya T, Takada I, Fukaya T, Sugiyama Y, Inoue N, Kimura A, Morita R, Kashiwagi I, Takimoto T, Nomura M, Yoshimura A
  • Journal Title: J Biol Chem Volume: 286(41) Pages: 35456-65
  • Peer Reviewed
• [Journal Article] Transcription Factor Smad-Independent T Helper 17 Cell Induction by Transforming-Growth Factor-β Is Mediated by Suppression of Eomesodermin (2011)
  • Author(s): Ichiyama K, Sekiya T, Inoue N, Tamiya T, Kashiwagi I, Kimura A, Morita R, Muto G, Shichita T, Takahashi R, Yoshimura A
  • Journal Title: Immunity Volume: 34(5) Pages: 741-54
  • Peer Reviewed
• [Journal Article] Effects of a Janus kinase inhibitor, pyridone 6, on airway responses in a murine model of asthma (2011)
  • Author(s): Matsunaga Y, Inoue H, Fukuyama S, Yoshida H, Moriwaki A, Matsumoto T, Matsumoto K, Asai Y, Kubo M, Yoshimura A, Nakanishi Y
  • Journal Title: Biochem Biophys Res Commun Volume: 404(1) Pages: 261-7
  • Peer Reviewed
• [Journal Article] Transcription Factor Smad-Independent T Helper 17 Cell Induction by Transforming-Growth Factor-ss Is Mediated by Suppression of Eomesodermin (2011)
  • Author(s): Kenji Ichiyama, 他
  • Journal Title: Immunity Volume: 34 Issue: 5 Pages: 741-754
  • DOI: 10.1016/j.immuni.2011.02.021
  • Peer Reviewed
• [Presentation] Sensitivity analysis of helper T cell differentiation (2012)
  • Author(s): Satoshi Yamada, Akihiko Yoshimura
  • Organizer: 第41回日本免疫学会 学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-05
• [Presentation] Sensitivity analysis of computer model of helper T cell differentiation (2012)
  • Author(s): Satoshi Yamada, Akihiko Yoshimura
  • Organizer: The 3rd Synthetic Immunology Workshop
  • Place of Presentation: 京都
  • Year and Date: 2012-05-19
• [Presentation] サイトカインによる免疫制御と脳内炎症 (2012)
  • Author(s): 吉村昭彦
  • Organizer: 第40回日本臨床免疫学会総会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 脳虚血後の炎症におけるDAMPs とサイトカインの役割 (2012)
  • Author(s): 吉村昭彦
  • Organizer: 第21回内毒素・LPS研究会
  • Place of Presentation: 東京
  • Invited
• [Presentation] Important factors in computer model of helper T cell differentiation (2011)
  • Author(s): Satoshi Yamada, Akihiko Yoshimura
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-14
• [Remarks]
  • URL: http://new.immunoreg.jp/