Understanding regulation of allergy by human single mutation using knock-in mouse line replacing with atopic type of human sequence

• Project/Area Number: 23659243
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Tokyo University of Science
• Principal Investigator: KUBO Masato 東京理科大学, 生命医科学研究所, 教授 (40277281)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: アレルギー / 免疫関連疾患 / 免疫学

Research Abstract

Human allergic patients have high IgE and IL-4 expression, which are typical phenotypes of allergic responses. We found two single nucleotide mutations (SNPs) in 3’ side of silencer region of Il4 locus, which associate with the IgE responses. We established the substitution knock-in lines introducing non-atopic type of SNPs or atopic type of SNPs in the human silencer region of Il4 locus. We demonstrated that the atopic type of SNPs in the human silencer region of Il4 locus controls higher IgE response, indicating that the atopic type of SNPs would be a strong genetic trait for allergic diseases.

Research Products

• [Journal Article] 自己免疫疾患・アレルギー疾患(前篇)免疫学の基礎,検査,治療:T細胞とサブセット (2013)
  • Author(s): 久保允人
  • Journal Title: 最新医学 Volume: 第68巻 3月増刊号
• [Journal Article] 特集I:サイトカインの産生・作用とシグナル伝達分子 マスト細胞と好塩基球におけるIL-4,IL-13遺伝子発現機構の相違 (2013)
  • Author(s): 本村泰隆・久保允人
  • Journal Title: 臨床免疫・アレルギー科 Volume: Vol.59, No3 Pages: 331-337
• [Journal Article] Il4遺伝子の制御とアレルギーとの関与 (2012)
  • Author(s): 本村泰隆・久保允人
  • Journal Title: アレルギーの臨床北隆館 Volume: No434, 2012.32巻, 9月号 Pages: 17-22
• [Journal Article] 濾胞性T細胞のIL-4産生制御とIgE抗体産生 (2012)
  • Author(s): 原田陽介・久保允人
  • Journal Title: 医学のあゆみ Volume: Vol243 No.8 Pages: 689-690
• [Journal Article] 胸腺内でのT細胞分化とサイトカイン (2012)
  • Author(s): 原田陽介・久保允人
  • Journal Title: 増刊号 「サイトカインのすべて」 臨床免疫・アレルギー科 Volume: Vol.57 Suppl.21 Pages: 664-669
• [Journal Article] I サイトカインの種類I サイトカインの種類 (2012)
  • Author(s): 久保允人
  • Journal Title: IL-4 増刊号 「サイトカインのすべて」臨床免疫・アレルギー科 Volume: Vol.57 Suppl.21 Pages: 27-32
• [Journal Article] アレルギーにおける白血球・リンパ球の役割 (2012)
  • Author(s): 久保允人
  • Journal Title: 理大 科学フォーラム Volume: 334 Pages: 38-40
  • NAID: 40019239053
• [Journal Article] 特集 「慢性アレルギー炎症-免疫系の役者たちの新たな姿 T細胞・好塩基球,サイトカインが織りなす慢性化のメカニズムとワクチン>開発」 慢性アレルギーに拘わる細胞系列とサイトカイン (2012)
  • Author(s): 久保允人
  • Journal Title: 実験医学 Volume: Vol. 30, No.6 Pages: 893-898
• [Journal Article] 特集 「慢性アレルギー炎症-免疫系の役者たちの新たな姿T細胞・好塩基球,サイトカインが織りなす慢性化のメカニズムとワクチン開発」 概要「アレルギー反応を舞台に活躍する役者たち」 (2012)
  • Author(s): 久保允人
  • Journal Title: 実験医学 Volume: Vol. 30, No.6 Pages: 886-892
• [Journal Article] 転写因子E4BP4によるIL-10とIL-13産生制御 (2012)
  • Author(s): 本村泰隆・久保允人
  • Journal Title: 医学のあゆみ Volume: vol.240 No.11 Pages: 932-933
• [Journal Article] GATA-3 によるIL-4・IL-13 遺伝子発現制御機構 (2012)
  • Author(s): 本村泰隆・久保允人
  • Journal Title: 臨床免疫・アレルギー科 Volume: 57(2) Pages: 211-215
• [Journal Article] Thymic Stromal Lymphopoietin-Dependent Basophils Promote Th2 Cytokine Responses following Intestinal Helminth Infection (2012)
  • Author(s): Giacomin, P.R., Siracusa, M.C., Walsh, K.P., Grencis, R.K., Kubo, M., Comeau, M.R., and Artis, D.
  • Journal Title: J. Immunol. Volume: 189(9) Pages: 4371-4378
  • Peer Reviewed
• [Journal Article] Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory (2012)
  • Author(s): Kaji, T., Ishige, A., Hikida, M., Taka, J., Hijikata, A., Kubo, M., Nagashima, T., Takahashi, Y., Kurosaki, T., Okada, M., Ohara, O., Rajewsky, K., Takemori, T.
  • Journal Title: J. Exp. Med. Volume: 209(11) Pages: 2079-2097
  • URL: http://jem.rupress.org/cgi/content/abstract/jem.20120127v1?etoc
  • Peer Reviewed
• [Journal Article] PGD2-CRTH2 Pathway Promotes Tubulointerstitial Fibrosis (2012)
  • Author(s): Ito, H., Yan, X., Nagata, N, Aritake, K., Katsumata, Y., Matsuhashi, T., Nakamura, M., Hirai, H., Urade, Y., Asano, K., Kubo, M., Utsunomiya, Y., Hosoya, T., Fukuda, K., and Sano, M.
  • Journal Title: J. Am. Soc. Nephrol.Nov Volume: 23(11) Pages: 1797-809
  • Peer Reviewed
• [Journal Article] Toll-like receptor (TLR) 3 as a surrogate sensor of retroviral infection in human cells (2012)
  • Author(s): Miyauchi, K., Urano, E., Takeda, S., Murakami, T., Okada, Y., Cheng, K., Yin, H., Kubo, M., and Komano, J.
  • Journal Title: Biochem. Biophys. Res .Commun. Volume: 424(3) Pages: 519-523
  • Peer Reviewed
• [Journal Article] Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors (2012)
  • Author(s): Kurashima, Y., Amiya, T., Nochi, T., Fujisawa, K., Haraguchi, T., Iba, H., Tsutsui, H., Sato, S., Nakajima, S., Iijima, H., Kubo, M., Kunisawa, J., and Kiyono, H.
  • Journal Title: Nat. Commun. Volume: 3 Pages: 1034-1034
  • Peer Reviewed
• [Journal Article] Transcriptional regulation of anti-inflammatory cytokine, IL-10 in acquired immune cells (2012)
  • Author(s): Kubo, M. & Motomura, Y.
  • Journal Title: Front. Immunol. Volume: 3 Pages: 275-275
  • URL: http://www.frontiersin.org/Journal/Abstract.aspx?s=1245&name=inflammation&ART_DOI=10.3389/fimmu.2012.00275
  • Peer Reviewed
• [Journal Article] Syk-dependent signaling pathways in neutrophils and macrophages are indispensable in the pathogenesis of anti-collagen antibody-induced arthritis (2012)
  • Author(s): Ozaki, N., Suzuki, S., Ishida, M., Harada, Y., Tanaka, K., Sato, Y., Kono, T., Kubo, M., Kitamura, D., Encinas, J., Hara, H., and Yoshida, H.
  • Journal Title: Int. Immunol. Volume: 24(9) Pages: 539-550
  • Peer Reviewed
• [Journal Article] Dysregulation of suppressor of cytokine signaling 3 in keratinocytes causes skin inflammation mediated by interleukin-20 receptor-related cytokines (2012)
  • Author(s): Uto-Konomi, A., Miyauchi, K., Ozaki, N., Motomura, Y., Suzuki, Y., Yoshimura, A., Suzuki, S., Cua, D., and Kubo, M.
  • Journal Title: PLoS One Volume: 7(7)
  • URL: http://dx.plos.org/10.1371/journal.pone.0040343.
  • Peer Reviewed
• [Journal Article] Elevation of Sema4A implicates Th cell skewing and the efficacy of IFN-β therapy in multiple sclerosis (2012)
  • Author(s): Nakatsuji, Y., Okuno, T., Moriya, M., Sugimoto, T., Kinoshita, M., Takamatsu, H., Nojima, S., Kimura, T., Kang, S., Ito, D., Nakagawa, Y., Toyofuku, T., Takata, K., Nakano, M., Kubo, M., Suzuki, S., Matsui-Hasumi, A., Uto-Konomi, A., Ogata, A., Mochizuki, H., Sakoda, S., and Kumanogoh, A.
  • Journal Title: J. Immunol. Volume: 188(10) Pages: 4858-4865
  • URL: http://www.jimmunol.org/content/early/2012/04/09/jimmunol
  • Peer Reviewed
• [Journal Article] Commensal bacterial-derived signals regulate basophil hematopoiesis and allergic inflammation (2012)
  • Author(s): Hill, D.A., Siracusa, M.C., Abt, M.C., Kim, B.S., Kobuley, D., Kubo, M., Kambayashi, T., Larosa, D.F., Renner, E.D., Orange, J.S., Bushman, F.D., and Artis D.
  • Journal Title: Nat. Med. Volume: 18(4) Pages: 538-546
  • Peer Reviewed
• [Journal Article] Development and Function of Invariant Natural Killer T cells Producing TH2- and TH17-cytokines (2012)
  • Author(s): Watarai, H., Sekine-Kondo, E., Motomura, Y., Yasuda, T., Yoshida, H., Kubo, M., Koseki, H., Taniguchi, M.
  • Journal Title: PLoS Biol Volume: 10(2)
  • Peer Reviewed
• [Journal Article] The 3′ Enhancer CNS2 is a Critical Regulator of Interleukin-4-Mediated Humoral Immunity in Follicular Helper T Cells (2012)
  • Author(s): Harada, Y., Tanaka, S., Motomura, Y., Harada, Y., Ohno, S., Ohno, S., Yanagi, Y., Inoue, H., and Kubo, M.
  • Journal Title: Immunity. Volume: 36(2) Pages: 188-200
  • Peer Reviewed
• [Journal Article] Role of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness (2012)
  • Author(s): Sawaguchi, M., Tanaka, S., Nakatani, Y., Harada, Y., Mukai, K., Matsunaga, Y., Ishiwata, K., Oboki, K., Kambayashi, T., Watanabe, N., Karasuyama, H., Nakae, S., Inoue, H., and Kubo, M.
  • Journal Title: J. Immunol. Volume: 188(4) Pages: 1809-1818
  • Peer Reviewed
• [Journal Article] Role of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness (2012)
  • Author(s): Sawaguchi, M., Tanaka, S., Nakatani, Y., Harada, Y., Mukai, K., Matsunaga, Y., Ishiwata, K., Oboki, K., Kambayashi, T., Watanabe, N., Karasuyama, H., Nakae, S., Inoue, H., and Kubo, M
  • Journal Title: J. Immunol Volume: 188(4) Pages: 1809-1818
  • Peer Reviewed
• [Journal Article] The 3′ Enhancer CNS2 is a Critical Regulator of Interleukin-4-Mediated Humoral Immunity in Follicular Helper T Cells (2012)
  • Author(s): Harada, Y., Tanaka, S., Motomura, Y., Harada, Y., Ohno, S., Ohno, S., Yanagi, Y., Inoue, H., and Kubo, M
  • Journal Title: Immunity Volume: 36(2) Pages: 188-200
  • Peer Reviewed
• [Journal Article] Development and Function of Invariant Natural Killer T cells Producing TH2- and TH17-cytokines (2012)
  • Author(s): Watarai, H., Sekine-Kondo, E., Motomura, Y., Yasuda, T., Yoshida, H., Kubo, M., Koseki, H., Taniguchi, M
  • Journal Title: PLoS Biol Volume: 10(2)
  • Peer Reviewed
• [Journal Article] Commensal bacterial–derived signals regulate basophil hematopoiesis and allergic inflammation (2012)
  • Author(s): Hill, D.A., Siracusa, M.C., Abt, M.C., Kim, B.S., Kobuley, D., Kubo, M., Kambayashi, T., Larosa, D.F., Renner, E.D., Orange, J.S., Bushman, F.D., and Artis D
  • Journal Title: Nat. Med Volume: 18(4) Pages: 538-546
  • Peer Reviewed
• [Journal Article] Elevation of Sema4A implicates Th cell skewing and the efficacy of IFN-β therapy in multiple sclerosis (2012)
  • Author(s): Nakatsuji, Y., Okuno, T., Moriya, M., Sugimoto, T., Kinoshita, M., Takamatsu, H., Nojima, S., Kimura, T., Kang, S., Ito, D., Nakagawa, Y., Toyofuku, T., Takata, K., Nakano, M., Kubo, M
  • Journal Title: J. Immunol Volume: 188(10) Pages: 4858-4865
  • Peer Reviewed
• [Journal Article] Dysregulation of suppressor of cytokine signaling 3 in keratinocytes causes skin inflammation mediated by interleukin-20 receptor-related cytokines (2012)
  • Author(s): Uto-Konomi, A., Miyauchi, K., Ozaki, N., Motomura, Y., Suzuki, Y., Yoshimura, A., Suzuki, S., Cua, D., and Kubo, M
  • Journal Title: PLoS One Volume: 7(7)
  • Peer Reviewed
• [Journal Article] Syk-dependent signaling pathways in neutrophils and macrophages are indispensable in the pathogenesis of anti-collagen antibody-induced arthritis (2012)
  • Author(s): Ozaki, N., Suzuki, S., Ishida, M., Harada, Y., Tanaka, K., Sato, Y., Kono, T., Kubo, M., Kitamura, D., Encinas, J., Hara, H., and Yoshida, H
  • Journal Title: Int. Immunol Volume: 24(9) Pages: 539-550
• [Journal Article] Transcriptional regulation of anti-inflammatory cytokine, IL-10 in acquired immune cells (2012)
  • Author(s): Kubo, M. & Motomura, Y
  • Journal Title: Front. Immunol Volume: 3
  • Peer Reviewed
• [Journal Article] Extracellular ATP mediates mast cell–dependent intestinal inflammation through P2X7 purinoceptors (2012)
  • Author(s): Kurashima, Y., Amiya, T., Nochi, T., Fujisawa, K., Haraguchi, T., Iba, H., Tsutsui, H., Sato, S., Nakajima, S., Iijima, H., Kubo, M., Kunisawa, J., and Kiyono, H
  • Journal Title: Nat. Commun Volume: 3
  • Peer Reviewed
• [Journal Article] Toll-like receptor (TLR) 3 as a surrogate sensor of retroviral infection in human cells (2012)
  • Author(s): Miyauchi, K., Urano, E., Takeda, S., Murakami, T., Okada, Y., Cheng, K., Yin, H., Kubo, M., and Komano, J
  • Journal Title: Biochem. Biophys. Res .Commun Volume: 424(3) Pages: 519-523
  • Peer Reviewed
• [Journal Article] PGD2-CRTH2 Pathway Promotes Tubulointerstitial Fibrosis (2012)
  • Author(s): Ito, H., Yan, X., Nagata, N, Aritake, K., Katsumata, Y., Matsuhashi, T., Nakamura, M., Hirai, H., Urade, Y., Asano, K., Kubo, M., Utsunomiya, Y., Hosoya, T., Fukuda, K., and Sano, M
  • Journal Title: J. Am. Soc. Nephrol Volume: Nov;23(11) Pages: 1797-1809
  • Peer Reviewed
• [Journal Article] Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory (2012)
  • Author(s): Kaji, T., Ishige, A., Hikida, M., Taka, J., Hijikata, A., Kubo, M., Nagashima, T., Takahashi, Y., Kurosaki, T., Okada, M., Ohara, O., Rajewsky, K., Takemori, T
  • Journal Title: J. Exp. Med Volume: 209(11) Pages: 2079-2097
  • Peer Reviewed
• [Journal Article] Thymic Stromal Lymphopoietin-Dependent Basophils Promote Th2 Cytokine Responses following Intestinal Helminth Infection (2012)
  • Author(s): Giacomin, P.R., Siracusa, M.C., Walsh, K.P., Grencis, R.K., Kubo, M., Comeau, M.R., and Artis, D
  • Journal Title: J. Immunol Volume: 189(9) Pages: 4371-4378
  • Peer Reviewed
• [Journal Article] GATA-3によるIL-4・IL-13 (2012)
  • Author(s): 本村泰隆・久保允人
  • Journal Title: 臨床免疫・アレルギー科 Volume: 57(2) Pages: 211-215
• [Journal Article] 特集 「慢性アレルギー炎症―免疫系の役者たちの新たな姿 T細胞・好塩基球，サイトカインが織りなす慢性化のメカニズムとワクチン開発」 概要 「アレルギー反応を舞台に活躍する役者たち」 (2012)
  • Author(s): 久保允人
  • Journal Title: 実験医学 Volume: Vol. 30, No.6 Pages: 886-892
• [Journal Article] 特集 「慢性アレルギー炎症―免疫系の役者たちの新たな姿 T細胞・好塩基球，サイトカインが織りなす慢性化のメカニズムとワクチン>開発」 慢性アレルギーに拘わる細胞系列とサイトカイン (2012)
  • Author(s): 久保允人
  • Journal Title: 実験医学 Volume: Vol. 30, No.6 Pages: 893-898
  • Peer Reviewed
• [Journal Article] アレルギーにおける白血球・リンパ球の役割 (2012)
  • Author(s): 久保允人
  • Journal Title: 理大 科学フォーラム Volume: 334 Pages: 38-4
  • NAID: 40019239053
• [Journal Article] サイトカインのすべて (2012)
  • Author(s): 久保允人
  • Journal Title: 臨床免疫・アレルギー科 Volume: Vol.57 Suppl.21 Pages: 27-32
• [Journal Article] サイトカインのすべて (2012)
  • Author(s): 原田陽介・久保允人
  • Journal Title: 臨床免疫・アレルギー科 Volume: Vol.57 Suppl.21 Pages: 664-669
• [Journal Article] Il4遺伝子の制御とアレルギーとの関与 (2012)
  • Author(s): 本村泰隆・久保允人
  • Journal Title: アレルギーの臨床 Volume: No434, .32巻 Pages: 17-22
• [Journal Article] サイトカインの産生・作用とシグナル伝達分子 マスト細胞と好塩基球におけるIL-4,IL-13遺伝子発現機構の相違 (2012)
  • Author(s): 本村泰隆・久保允人
  • Journal Title: 臨床免疫・アレルギー科 Volume: Vol.59, No3 Pages: 331-337
• [Journal Article] 自己免疫疾患・アレルギー疾患(前篇)免疫学の基礎,検査,治療：T細胞とサブセット (2012)
  • Author(s): 久保允人
  • Journal Title: 最新医学 Volume: 第68巻 3月増刊号
• [Journal Article] Commensal bacterial & derived signals regulate basophil hematopoiesis and allergic inflammation (2012)
  • Author(s): Hill, D., A., M.C.M.C., Siraousa, B.S., Abt, Kobuley, K.D., Kubo, M, Kambayashi, T., LaRosa, DF., Renner, ED., Orange, JS., Bushman, FD., Artis, D
  • Journal Title: Nature Medicine Volume: Mar 25 ; 18(4) Issue: 4 Pages: 538-46
  • DOI: 10.1038/nm.2657
  • Peer Reviewed
• [Journal Article] Development and Function of Invariant Natural Killer T cells Producing TH2- and TH17-cytokines (2012)
  • Author(s): Watarai H, Sekine-Kondo E, Shigeura T, Motomura Y, Yasuda T, Satoh R, Yoshida H, Kubo M, Kawamoto H, Koseki H, Taniguchi M
  • Journal Title: PLoS Biol Volume: 10 Issue: 2 Pages: e1001255-e1001255
  • DOI: 10.1371/journal.pbio.1001255
  • Peer Reviewed
• [Journal Article] The 3' Enhancer CNS2 Is a Critical Regulator of Interleukin-4-Mediated Humoral Immunity in Follicular Helper T Cells (2012)
  • Author(s): 原田陽介, 久保允人, 井上博雅, 他
  • Journal Title: Immunity Volume: 36 Issue: 2 Pages: 188-200
  • DOI: 10.1016/j.immuni.2012.02.002
  • Peer Reviewed
• [Journal Article] Role of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness (2012)
  • Author(s): Sawaguchi, M.
  • Journal Title: J.Immunol. Volume: 188 Issue: 4 Pages: 1809-1818
  • DOI: 10.4049/jimmunol.1101746
  • Peer Reviewed
• [Journal Article] Coreceptor gene imprinting governs thymocyte lineage fate (2011)
  • Author(s): Adoro, S., McCaughtry, T., Erman, B., Alag, A., Van, Laethem F., Park, J.H., Tai, X., Kimura, M., Wang, L., Grinberg, A., Kubo, M., Bosselut, R., Love, P., and Singer, A.
  • Journal Title: EMBO J. Volume: 31(2) Pages: 366-377
  • Peer Reviewed
• [Journal Article] Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity (2011)
  • Author(s): Otsuka, A., Kubo, M., Honda, T., Egawa, G., Nakajima, S., Tanizaki, H., Kim, B., Matsuoka, S., Nakae, S., Watanabe, T., Miyachi, Y., and Kabashima, K.
  • Journal Title: PLoS One Volume: 6(9)
  • Peer Reviewed
• [Journal Article] TSLP promotes interleukin-3-independent basophil hematopoiesis and type 2 inflammation (2011)
  • Author(s): Siracusa, M. C., Saenz, S. A., Hill, D. A., Kim, B. S. Headley, M. B., Doering, T. A., Wherry, E.J., Jessup, H. K., Siegel, L. A., Kambayashi, T., Dudek, E. C., Kubo, M., Cianferoni, A., Spergel, J. M., Ziegler, S. F., Comeau, M. R., and Artis, D.
  • Journal Title: Nature Volume: 477(7363) Pages: 229-233
  • Peer Reviewed
• [Journal Article] The transcription factor E4BP4 regulates the production of IL -10 and IL-13 in CD4+ T cells (2011)
  • Author(s): Motomura, Y., Kitamura, H., Hijikata, A., Matsunaga, Y., Matsumoto, K., Inoue, H., Atarashi, K., Hori, S., Watarai, H., Zhu, J., Taniguchi, M., and Kubo, M.
  • Journal Title: Nat. Immunol. Volume: 12(5) Pages: 450-459
  • Peer Reviewed
• [Journal Article] Coreceptor imprinting: The Cd8 gene locus programs any CD4/CD8 coreceptor protein it encodes to promote the cytotoxic lineage fate. (2011)
  • Author(s): Adoro, S. Erman, B., Alag, A., Van Laethem, F., Park, J-H., McCaughtry, T., Wang, L., Grinberg, A., Kubo, M., Bosselut, R., Love, P., and Singer, A.,
  • Journal Title: EMBO J. Volume: 31(2) Issue: 2 Pages: 366-77
  • DOI: 10.1038/emboj.2011.388
  • Peer Reviewed
• [Journal Article] Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity (2011)
  • Author(s): 大塚篤司、中島沙恵子, 他
  • Journal Title: Plos One Volume: 6 Issue: 9 Pages: 229-233
  • DOI: 10.1371/journal.pone.0025538
  • Peer Reviewed
• [Journal Article] The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells (2011)
  • Author(s): Motomura, Y., et al
  • Journal Title: Nature Immunology Volume: 12 Issue: 5 Pages: 450-459
  • DOI: 10.1038/ni.2020
  • Peer Reviewed
• [Presentation] Role of Notch signal in the generation of follicular helper T cells (TFH) and memory T cell (2013)
  • Author(s): Kubo, M.
  • Organizer: The 1st. International Immunological Memory and Vaccine Forum
  • Place of Presentation: Tokyo
  • Year and Date: 2013-01-29
• [Presentation] 抗体はどこでつくられるか? そしてワクチンへ (2013)
  • Author(s): 久保允人
  • Organizer: 第9回宮崎サイエンスキャンプ 宮崎サイエンスキャンプ
  • Place of Presentation: シーガイヤコンベンションセンター 宮崎
• [Presentation] 抗体はどこでつくられるか？ そしてワクチンへ (2013)
  • Author(s): 久保允人
  • Organizer: 第9回宮崎サイエンスキャンプ
  • Place of Presentation: シーガイヤコンベンションセンター 宮崎
  • Invited
• [Presentation] 慢性炎症におけるIL-10働きとその制御 (2013)
  • Author(s): 久保允人
  • Organizer: 第45回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 東京
  • Invited
• [Presentation] Role of follicular helper T cells (TFH) in antibody responses (2012)
  • Author(s): Kubo, M.
  • Organizer: Distinguished Lecture Series in MD Anderson
  • Place of Presentation: Huston TX USA
  • Year and Date: 2012-12-17
• [Presentation] 「科学は技術を拓き、技術は科学を深める」サイトカインとアレルギー (2012)
  • Author(s): 久保允人
  • Organizer: TUSフォーラム2012
  • Place of Presentation: ホテルメトロポリタンエドモンド(飯田橋) 東京
  • Year and Date: 2012-10-30
• [Presentation] 「難治性免疫疾患・アレルギー疾患の克服をめざして」 IgE抗体とアレルギー (2012)
  • Author(s): 久保允人
  • Organizer: 筑波大学、東京理科大学生命医科学研究所合同シンポジウム
  • Place of Presentation: 学士会館 東京
  • Year and Date: 2012-10-19
• [Presentation] 抗炎症サイトカインIL-10の可塑的発現による抗炎症制御 (2012)
  • Author(s): 久保允人
  • Organizer: 第33回日本炎症・再生医学会
  • Place of Presentation: ホテル日航福岡 博多
  • Year and Date: 2012-07-05
• [Presentation] 濾胞型ヘルパーT細胞(TFH細胞)による抗体産生制御 (2012)
  • Author(s): 久保允人
  • Organizer: 免疫学・アトーピセンターセミナー
  • Place of Presentation: 順天堂大学 東京
  • Year and Date: 2012-04-27
• [Presentation] アレルギーにおける白血球・リンパ球の役割 (2012)
  • Author(s): 久保允人
  • Organizer: 第7回鹿児島呼吸器セミナー
  • Place of Presentation: 鹿児島大学 鹿児島
  • Year and Date: 2012-03-27
• [Presentation] Th2アジュバンドの現状 (2012)
  • Author(s): 久保允人
  • Organizer: 第81回日本寄生虫学会大会シンポジウム3
  • Place of Presentation: 兵庫医科大学 兵庫
  • Year and Date: 2012-03-23
• [Presentation] Regulation of IL-4 mediated humoral immunity by Follicular helper T cells (2012)
  • Author(s): Kubo, M.
  • Organizer: IFReC seminar
  • Place of Presentation: Osaka
  • Year and Date: 2012-02-24
• [Presentation] Role of follicular helper T (TFH) cell in influenza A virus infection and vaccination Keystone Symposia Vaccination Conference (2012)
  • Author(s): Miyauchi, K., Kaji, T., Takemori, T., and Kubo, M.
  • Place of Presentation: Ottawa, Canada
• [Presentation] Folicular helper T cells arise from type 2helper T cells and control humoral immune responses (2012)
  • Author(s): Harada,Y., Harada,Y., Kubo, M.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] Critical role of follicular helper T cells in the IgE response to T-D antigens and serum neutralization activity in virus infection (2012)
  • Author(s): Miyauchi, K., Harada, Y., Motomura, Y., Kaji, T., Takemori, T., Kubo, M.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] The 3' enhancer, CNS2 is a crucial regulator of IL-4 mediated humoral immunity in follicular helper T cells (2012)
  • Author(s): Harada, Y., Harada, Y., Honjo, T., Takemori, T., Kubo, M.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] 3rd Internatinal Conference of Treg and Th subsets (2012)
  • Author(s): Kubo, M.
  • Organizer: Critical role of follicular helper T cells in the humoral immunity to T-D antigens and influenza virus
  • Place of Presentation: Shanghai,China
• [Presentation] 第3回 Molecular Cardiovascular Conference (2012)
  • Author(s): 久保允人
  • Organizer: 時計制御分子による抗炎症性サイトカインIL-10の転写制御
  • Place of Presentation: ホテルピアノ 北海道・キロロ
• [Presentation] Functions of Tfh cells in influenza virus infection and airway hyperreactivity (2012)
  • Author(s): 宮内浩典、原田康代、加地友弘、鈴木芳枝、井上博雅、竹森利忠、久保允人
  • Organizer: 第22回京都T細胞会議
  • Place of Presentation: 京都
• [Presentation] The 3' enhancer, CNS2 is a crucial regulator of IL-4 mediated humoral immunity in follicular helper T cells (2012)
  • Author(s): 原田陽介、本村泰隆、原田康代、久保允人
  • Organizer: 第22回京都T細胞会議
  • Place of Presentation: 京都
• [Presentation] Regulation of cytokine expression in Follicular helper T cell and humoral immunity. (2012)
  • Author(s): Kubo, M.
  • Organizer: RIKEN Research Center for Allergy and Immunology RCAI-JSI International Symposium on Immunology
  • Place of Presentation: Yokohama
• [Presentation] 第77回日本サイトカイン・インターフェロン学会 (2012)
  • Author(s): 久保允人
  • Organizer: 濾胞型ヘルパーT細胞(TFH細胞)による抗体産生制御
  • Place of Presentation: 神戸
• [Presentation] Regulation of IL-4 mediated humoral immunity by Follicular helper T cells (2012)
  • Author(s): Kubo, M.
  • Organizer: The 4th RCAI-LIAI Workshop
  • Place of Presentation: La Jolla CA USA
• [Presentation] 濾胞型ヘルパーT細胞（TFH細胞）による抗体産生制御 (2012)
  • Author(s): 久保允人
  • Organizer: 第77回日本サイトカイン・インターフェロン学会
  • Place of Presentation: 神戸
  • Invited
• [Presentation] 時計制御分子による抗炎症性サイトカインIL-10の転写制御 (2012)
  • Author(s): 久保允人
  • Organizer: 第3回 Molecular Cardiovascular Conference
  • Place of Presentation: ホテルピアノ 北海道・キロロ
  • Invited
• [Presentation] Regulation of cytokine expression in Follicular helper T cell and humoral immunity (2012)
  • Author(s): Masato Kubo
  • Organizer: RIKEN Research Center for Allergy and Immunology RCAI-JSI International Symposium on Immunology
  • Place of Presentation: Yokohama
  • Invited
• [Presentation] Critical role of follicular helper T cells in the humoral immunity to T-D antigens and influenza virus (2012)
  • Author(s): Masato Kubo
  • Organizer: 3rd Internatinal Conference of Treg and Th subsets
  • Place of Presentation: Shanghai
  • Invited
• [Presentation] The 3’ enhancer, CNS2 is a crucial regulator of IL-4 mediated humoral immunity in follicular helper T cells (2012)
  • Author(s): 原田陽介、本村泰隆、原田康代、久保允人
  • Organizer: 第22回京都T細胞会議
  • Place of Presentation: 京都
• [Presentation] The 3’ enhancer, CNS2 is a crucial regulator of IL-4 mediated humoral immunity in follicular helper T cells (2012)
  • Author(s): Harada, Y., Harada, Y., Honjo, T., Takemori, T., Kubo, M
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] Role of follicular helper T (TFH) cell in influenza A virus infection and vaccination (2012)
  • Author(s): Miyauchi, K., Kaji, T., Takemori, T., and Kubo, M
  • Organizer: Keystone Symposia Vaccination Conference
  • Place of Presentation: Ottawa
• [Presentation] アレルギーにおける白血球・リンパ球の役割 (2012)
  • Author(s): 久保允人
  • Organizer: 第7回鹿児島呼吸器セミナー(招待講演)
  • Place of Presentation: 鹿児島
• [Presentation] シンポジウム3「Th2アジュバンドの現状」 (2012)
  • Author(s): 久保允人
  • Organizer: 第81回日本寄生虫学会大会(招待講演)
  • Place of Presentation: 兵庫
• [Presentation] Regulation of IL-4 mediated humoral immunity by Follicular helper T cells (2012)
  • Author(s): Kubo Masato
  • Organizer: IFReC seminar(招待講演)
  • Place of Presentation: Osaka
• [Presentation] Regulation of IL-4 mediated humoral immunity by Follicular helper T cells (2012)
  • Author(s): Kubo Masato
  • Organizer: The 4th RCAI-LIAI Workshop(招待講演)
  • Place of Presentation: La Jolla CA USA
• [Presentation] (2011)
  • Author(s): Kubo, M.
  • Organizer: The 34th Annual Meeting of the Molecular Biology Society of Japan
  • Place of Presentation: Yokohama
  • Year and Date: 2011-12-14
• [Presentation] Regulation of IL-4 mediated humoral immunity by Follicular helper T cells (2011)
  • Author(s): Kubo, M.
  • Organizer: 6th Chiba University Global COE Symposium
  • Place of Presentation: Chiba
  • Year and Date: 2011-11-30
• [Presentation] Lineage-specific enhancer is responsible for expression of Il4 and Il13 genes in mast cells and basophils (2011)
  • Author(s): Yasutaka Motomura, Shinya Tanaka, Masato Kubo
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-29
• [Presentation] IgG memory B cell development in TFH-dependent and -independent pathways (2011)
  • Author(s): Kaji Tomohiro, Harada Yasuyo,Sugimoto Akiko, Motomura Yasutaka, Kubo Masato, Takemori Toshitada
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] The role of β-catenin signaling in Th17 celldifferentiation (2011)
  • Author(s): Matsui Akiko, Sato Yayoi, Suzuki Shinobu, Encinas Jeffrey, Asahara Hiroshi, Yoshida Hideyuki, Yoshimura Akihiko, Yamashita Masakatsu, Kubo Masato
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] Distinct mechanisms govern the ex-pression of IL-4 in TFH and TH2 cells (2011)
  • Author(s): Arima Masafumi, Inamini Ayako, Kohashi Yuko, Sakamoto Akemi, Hatano Masahiko, Kubo Masato, Tokuhisa Takeshi
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] The role of basophils in skin Th2 response using newly generated basophil-specific conditional depletion model (2011)
  • Author(s): Otsuka Atsushi, Kubo Masato, Miyachi Yoshiki, Kabashima Kenji
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] The IL-4 enhancer CNS-2 is critical for Follicular helper T (TFH) cell function and immunoglobulin G1 class switching (2011)
  • Author(s): Yohsuke Harada, Yasuyo Harada, Yusuke Yamakita, Masato Kubo
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] Regulation of IL-4 mediated natural antibody in peyer's Patch (2011)
  • Author(s): Masato Kubo
  • Organizer: Novel Approaches For Infectious Disease Research
  • Place of Presentation: Yokohama
  • Year and Date: 2011-10-21
• [Presentation] 皮膚ホメオスターシス破綻に伴う炎症性疾患の誘導機構 (2011)
  • Author(s): 久保允人
  • Organizer: 第14回山梨皮膚疾患研究会
  • Place of Presentation: 日山梨大学甲府
  • Year and Date: 2011-10-06
• [Presentation] 「サイトカイン研究の最新の進捗:創薬標的を求めて」 ヘルパーT細胞の分化メカニズムとサイトカインの可塑的発現 (2011)
  • Author(s): 久保允人
  • Organizer: 東京大学医科学研究所 発生工学 第88回定例会
  • Place of Presentation: 東京大学医科学研究所 東京
  • Year and Date: 2011-09-28
• [Presentation] 時計制御分子E4BPによる抑制性サイトカインIL-10の制御 (2011)
  • Author(s): 久保允人
  • Organizer: 東京理科大学 生命科学研究科 大学院特別講義 免疫記憶・炎症研究の新展開
  • Place of Presentation: 東京理科大学カナル会館 野田
  • Year and Date: 2011-09-03
• [Presentation] Th17細胞におけるWnt/ -cateninシグナルの役割 (2011)
  • Author(s): 松井明子、佐藤弥生、鈴木忍、Jeffrey Encinas、浅原弘嗣、吉村昭彦、山下政克、久保允人
  • Organizer: 第21回京都T細胞会議
  • Place of Presentation: 京都
  • Year and Date: 2011-06-11
• [Presentation] The IL-4 enhancer CNS-2 is critical for Follicular helper T(TFH) cell function and immunoglobulin G1 class switching (2011)
  • Author(s): Yohsuke Harada, Yasuyo Harada, Yusuke Yamashita, Masato Kubo
  • Organizer: 第21回京都T細胞会議
  • Place of Presentation: 京都
  • Year and Date: 2011-06-11
• [Presentation] 転写因子E4BP4 によるCD4+T 細胞におけるIL-10発現制御細胞 (2011)
  • Author(s): 本村泰隆、北村浩、土方敦司、松永悠子、松本幸一郎、井上博雅、新幸二、堀昌平、渡会浩次、Jinfang Zhu、谷口克、久保允人
  • Organizer: 第21回京都T細胞会議
  • Place of Presentation: 京都
  • Year and Date: 2011-06-11
• [Presentation] 「マスト細胞・好塩基球欠損マウスを用いたアレルギー疾患の病態解明」マスト細胞・好塩基球欠損マウスシステムの構築とサイトカイン産生能 (2011)
  • Author(s): 久保允人
  • Organizer: 第61回日本アレルギー学会シンポジウム
  • Place of Presentation: 東京
• [Presentation] IIgG memory B cell development in TFH-dependent and-independent pathways. (2011)
  • Author(s): Kaji Tomohiro, Harada Yasuyo, Sugimoto Akiko, Motomura Yasutaka, Kubo Masato, Takemori Toshitada
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
• [Presentation] The role of β-catenin signaling in Th17 celldifferentiation. (2011)
  • Author(s): Matsui Akiko, Sato Yayoi, Suzuki Shinobu, Encinas Jeffrey, Asahara Hiroshi, Yoshida Hideyuki, Yoshimura Akihiko, Yamashita Masakatsu, Kubo Masato
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
• [Presentation] Distinct mechanisms govern the ex-pression of IL-4 in TFH and TH2 cells. (2011)
  • Author(s): Arima Masafumi, Inamini Ayako, Kohashi Yuko, Sakamoto Akemi, Hatano Masahiko, Kubo Masato, Tokuhisa Takeshi
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
• [Presentation] The role of basophils in skin Th2 response using newly generated basophil-specific conditional depletion model. (2011)
  • Author(s): Otsuka Atsushi, Kubo Masato, Miyachi Yoshiki, Kabashima Kenji
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
• [Presentation] Th17細胞におけるWnt/β-cateninシグナルの役割 (2011)
  • Author(s): 松井明子、佐藤弥生、鈴木忍、Jeffrey Encinas、浅原弘嗣、吉村昭彦、山下政克、久保允人
  • Organizer: 第21回京都T細胞会議
  • Place of Presentation: 京都
• [Presentation] 転写因子E4BP4によるCD4+T細胞におけるIL-10発現制御細胞 (2011)
  • Author(s): 本村泰隆、北村浩、土方敦司、松永悠子、松本幸一郎、井上博雅、新幸二、堀昌平、渡会浩次、Jinfang Zhu、谷口克、久保允人
  • Organizer: 第21回京都T細胞会議
  • Place of Presentation: 京都
• [Presentation] シンポジウム13 「マスト細胞・好塩基球欠損マウスを用いたアレルギー疾患の病態解明」 (2011)
  • Author(s): 久保允人
  • Organizer: 第61回日本アレルギー学会(招待講演)
  • Place of Presentation: 東京
• [Presentation] 「皮膚ホメオスターシス破綻に伴う炎症性疾患の誘導機構」 (2011)
  • Author(s): 久保允人
  • Organizer: 第14回山梨皮膚疾患研究会(招待講演)
  • Place of Presentation: 甲府
• [Presentation] 「サイトカイン研究の最新の進捗：創薬標的を求めて」 ヘルパーT細胞の分化メカニズムとサイトカインの可塑的発現 (2011)
  • Author(s): 久保允人
  • Organizer: 東京大学医科学研究所 発生工学 第88回定例会(招待講演)
  • Place of Presentation: 東京
• [Presentation] 「時計制御分子E4BPによる抑制性サイトカインIL-10の制御」 (2011)
  • Author(s): 久保允人
  • Organizer: 東京理科大学 生命科学研究科 大学院特別講義 免疫記憶・炎症研究の新展開(招待講演)
  • Place of Presentation: 野田
• [Presentation] Epigenetic regulation of anti-inflammatory cytokine by clock regulator, E4BP4/NFIL-3 (2011)
  • Author(s): Kubo Masato
  • Organizer: The 34th Annual Meeting of the Molecular Biology Society of Japan(招待講演)
  • Place of Presentation: Yokohama
• [Presentation] Regulation of IL-4 mediated humoral immunity by Follicular helper T cells (2011)
  • Author(s): Kubo Masato
  • Organizer: 6th Chiba University Global COE Symposium(招待講演)
  • Place of Presentation: Chiba
• [Presentation] Regulation of IL-4 mediated natural antibody in peyer’s Patch (2011)
  • Author(s): Kubo Masato
  • Organizer: Novel Approaches For Infectious Disease Research(招待講演)
  • Place of Presentation: Yokohama
• [Presentation] 濾胞型ヘルパーT細胞（TFH細胞）による抗体産生制御
  • Author(s): 久保允人
  • Organizer: 免疫学・アトーピセンターセミナー
  • Place of Presentation: 順天堂大学 東京
  • Invited
• [Presentation] 抗炎症サイトカインIL-10の可塑的発現による抗炎症制御
  • Author(s): 久保允人
  • Organizer: 第33回日本炎症・再生医学会
  • Place of Presentation: ホテル日航福岡 博多
  • Invited
• [Presentation] 「難治性免疫疾患•アレルギー疾患の克服をめざして」 IgE抗体とアレルギー
  • Author(s): 久保允人
  • Organizer: 筑波大学、東京理科大学生命医科学研究所合同シンポジウム
  • Place of Presentation: 学士会館 東京
  • Invited
• [Presentation] サイトカインとアレルギー
  • Author(s): 久保允人
  • Organizer: ＴＵＳフォーラム２０１２「科学は技術を拓き、技術は科学を深める」
  • Place of Presentation: ホテルメトロポリタンエドモンド（飯田橋） 東京
  • Invited
• [Presentation] サイトカインとシグナル伝達
  • Author(s): 久保允人
  • Organizer: 第57回日本リウマチ学会総会・学術集会
  • Place of Presentation: 国立京都国際会館 京都
  • Invited
• [Presentation] Role of follicular helper T cells (TFH) in antibody responses
  • Author(s): Masato Kubo
  • Organizer: Distinguished Lecture Series in MD Anderson
  • Place of Presentation: Huston TX USA
  • Invited
• [Presentation] Role of Notch signal in the generation of follicular helper T cells (TFH) and memory T cell
  • Author(s): Masato Kubo
  • Organizer: The 1st. International Immunological Memory and Vaccine Forum
  • Place of Presentation: Tokyo
  • Invited
• [Remarks]
  • URL: http://www.rs.noda.tus.ac.jp/~ribsjm/kubolab/