| Project/Area Number |
23659244
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
ISHII Shunsuke 独立行政法人理化学研究所, 石井分子遺伝学研究室, 主任研究員 (00124785)
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| Project Period (FY) |
2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | ウイルス感染 / 代謝 / 細胞増殖 / TNF-α / 免疫系 / 代謝系 / リンケージ / TRIM / コレステロール |
|---|
| Research Abstract |
TNF-α, which induces inflammatory mediators and apoptosis, is induced by pathogen infection, and is involved in pathogen protection. We have identified new TRIM protein that functions in the TNF-αsignaling pathway. In the liver lacking this TRIM protein, the levels of genes that are involved in the biosynthesis of cholesterol and lipid are increased. This suggests that this TRIM protein is involved in the regulation of metabolism as well as in the pathogen protection via regulating the TNF-αsignaling pathway. Thus, the key regulator that links the immune system and metabolism has been identified.
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