| Project/Area Number |
23659247
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Toyama Prefectural Institute. for Pharmaceutical Research. |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAGAI Yoshinori 富山大学, 大学院医学薬学研究部(医学), 准教授 (30431761)
MATSUNAGA Takayuki 富山県薬事研究所, 主幹研究員 (30121289)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | アレルギー / 免疫関連疾患 / 自然免疫 / 非感染性慢性炎症 / TLR / 天然物 / 肥満 / 糖尿病 / IL-5 |
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| Research Abstract |
(1) We identified innate IL-5-producing cells by using the IL-5 reporter mice.(2) RP105 expression dramatically increased in the adipose tissue from high-fat diet fed mice and obese subjects.(3) We established assay systems useful for analyzing immune regulation, and evaluated the natural compounds for their regulatory effects on the immune system. As a result, we identified several compounds as medicinal seeds useful for an allergy medication, an immune-stimulator, and an anti-diabetic drug.(4) We find mechanisms, in part, by which these compounds regulate the immune system.
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