| Project/Area Number |
23659268
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical sociology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKASHIMA Emi 慶應義塾大学, 薬学部, 教授 (90115254)
HASHIGUCHI Masayuki 慶應義塾大学, 薬学部, 准教授 (10271355)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 服薬カウンセリング / 禁煙支援 / 光トポグラフィ / 機能的近赤外分光法(NIRS) / 言語流暢性課題 / 脳機能イメージング / 前頭前野 / 機能的近赤外分光法(NIRS） / プラセボ効果 |
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| Research Abstract |
We conducted two studies of hemodynamic response in the brain to evaluate objectively and scientifically the efficacy of smoking cessation counseling by pharmacists. (1) the reproducibility of brain blood flow using a NIRS by three cognitive tasks, (2) the effect of smoking and short-term smoking cessation on brain blood flow.
We selected LFT for our study, because it showed the most sufficient result in reproducibility among three cognitive tasks. It was suggested that the change of brain blood flow was more significantly influenced by addiction, withdrawal symptoms, and urge at the smoking cessation than nicotine concentration in blood. It is necessary to consider the influence of addiction, withdrawal symptoms and urge, when we plan the study protocol to evaluate the efficacy of smoking cessation counseling by pharmacists.
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