The development of the side effect prediction of the anticancer agent which assumed intestinal tract immunity an index and the rating system
| Project/Area Number |
23659278
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | Hokkaido University |
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Principal Investigator |
ISEKI Ken 北海道大学, 大学院・薬学研究院, 教授 (40203062)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Natsuko 北海道薬科大学, 薬学部, 講師 (60535293)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | がん化学療法 / 相互作用 / 腸管免疫 / α-ディフェンシン / 食品素材 / 経口抗がん薬 / α-defensin / 薬物間相互作用 / 医薬品副作用 / 機能性食品 / 抗がん剤 |
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| Research Abstract |
We detected HD-5 and HD-6 mRNA in Caco-2 cells and evaluated the effects of an oral anticancer drugs. HD-5 and HD-6 mRNA levels were decreased by exposure of tegafur. Moreover, the decrease of the HDs mRNA levels were associated with the increase of IL-1 and IL-8 by tegafur. In addition, we clarified antioxidant materials suppressed theexpression of α-defensins induced by FT at the transcriptional level in Caco-2 cells.
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Report
(3 results)
Research Products
(5 results)
