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The development of the side effect prediction of the anticancer agent which assumed intestinal tract immunity an index and the rating system

Research Project

Project/Area Number 23659278
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied pharmacology
Research InstitutionHokkaido University

Principal Investigator

ISEKI Ken  北海道大学, 大学院・薬学研究院, 教授 (40203062)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Natsuko  北海道薬科大学, 薬学部, 講師 (60535293)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsがん化学療法 / 相互作用 / 腸管免疫 / α-ディフェンシン / 食品素材 / 経口抗がん薬 / α-defensin / 薬物間相互作用 / 医薬品副作用 / 機能性食品 / 抗がん剤
Research Abstract

We detected HD-5 and HD-6 mRNA in Caco-2 cells and evaluated the effects of an oral anticancer drugs. HD-5 and HD-6 mRNA levels were decreased by exposure of tegafur. Moreover, the decrease of the HDs mRNA levels were associated with the increase of IL-1 and IL-8 by tegafur. In addition, we clarified antioxidant materials suppressed theexpression of α-defensins induced by FT at the transcriptional level in Caco-2 cells.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (5 results)

All 2012 2011

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Basic investigation for classification of anticancer drugs by pharmacological effects2012

    • Author(s)
      Takahashi N, Kobayashi M, Itagaki S, Hirano T, Takekuma Y, Sugawara M, Iseki K
    • Journal Title

      Yakugaku Zasshi

      Volume: 132(6) Pages: 777-783

    • NAID

      130001888693

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] テガフールの腸管吸収機構に関する研究2012

    • Author(s)
      澤田真衣、高橋夏子、小林正紀、佐々木将太郎、井関健.
    • Organizer
      第26回北海道薬物作用談話会
    • Place of Presentation
      札幌、北海道大学薬学部臨床薬学講義室
    • Year and Date
      2012-07-28
    • Related Report
      2012 Final Research Report
  • [Presentation] サプリメントの効用とデメリット~科学的考察を軸にして2012

    • Author(s)
      井関健
    • Organizer
      第2回日本未病システム学会北海道支部会
    • Place of Presentation
      札幌、北海道大学学術交流会館
    • Related Report
      2012 Final Research Report
  • [Presentation] Epigallocatechingallateが経口抗がん薬由来の腸管免疫低下に与える影響2011

    • Author(s)
      高橋夏子、小林正紀、澤田真衣、山田武宏、井関健
    • Organizer
      第21回日本医療薬学会
    • Place of Presentation
      神戸、神戸国際会議場
    • Year and Date
      2011-10-12
    • Related Report
      2012 Final Research Report
  • [Presentation] Epigallocatechin gallateが経口抗がん薬由来の腸管免疫低下に与える影響2011

    • Author(s)
      高橋夏子,小林正紀,澤田真衣,山田武宏,井関 健
    • Organizer
      第21回日本医療薬学会年会
    • Place of Presentation
      神戸国際会議場(兵庫)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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