The search for elucidating the contribution of chronic inflammation to the development of heart failure and for new treatment
Project/Area Number |
23659279
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Applied pharmacology
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Research Institution | University of Tsukuba |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
SAKAI Satoshi 筑波大学, 医学医療系, 講師 (30282362)
SHIMANO Hitoshi 筑波大学, 医学医療系, 教授 (20251241)
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Co-Investigator(Renkei-kenkyūsha) |
MARUYAMA Hidekazu 筑波大学, 附属病院, 病院講師 (30528493)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | 心不全 / 慢性炎症 / 酸化ストレス / 不全心筋 / 炎症反応 |
Research Abstract |
The activation of angiotensin system contributes to the development of failing heart. Chronic administration of angiotensin II (AngII) lowered cardiac ejection faraction (EF) in wild mice, however, it did not change in mice deficient of the transcription factor SREBP-1. Reactive oxygen species is involved in AngII-induced organ injury. The expression level of both the master regulator for antioxidant Nrf2, a transcription factor, and Nrf2 regulating gene for antioxidative stress was significantly decreased by AngII administration in the heart; conversely, the expression level of them did not differ in KO. Taken together, cardiac dysfunction induced by Ang II may be associated with the reduced expression of Nrf2 and its regulatory gene against antioxidative stress.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Prognostic value of serum tenascin-C levels on long-term outcome after acute myocardial infarction2012
Author(s)
Sato A, Hiroe M, Akiyama D, Hikita H, Nozato T, Hoshi T, Kimura T, Wang Z, Sakai S, Imanaka-Yoshida K, Yoshida T, Aonuma K
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Journal Title
J Card Fail
Volume: 18
Pages: 480-6
Related Report
Peer Reviewed
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[Journal Article] Inhibition of ubiquitin ligase F-box and WD repeat domain-containing 7α (Fbw7α) causes hepatosteatosis through Krueppel-like factor 5 (KLF5)/peroxisome proliferator-activated receptor γ2 (PPARγ2) pathway but not SREBP-1c protein in mice2011
Author(s)
Kumadaki S, Karasawa T, Matsuzaka T, Ema M, Nakagawa Y, Nakakuki M, Saito R, Yahagi N, Iwasaki H, Sone H, Takekoshi K, Yatoh S, Kobayashi K, Takahashi A, Suzuki H, Takahashi S, Yamada N, Shimano H
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Journal Title
J Biol Chem
Volume: 286
Pages: 40835-46
Related Report
Peer Reviewed
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[Journal Article] Sterol regulatory element-binding protein-1 determines plasma remnant lipoproteins and accelerates atherosclerosis in low-density lipoprotein receptor-deficient mice2011
Author(s)
Karasawa T, Takahashi A, Saito R, Sekiya M, Igarashi M, Iwasaki H, Miyahara S, Koyasu S, Nakagawa Y, Ishii K, Matsuzaka T, Kobayashi K, Yahagi N, Takekoshi K, Sone H, Yatoh S, Suzuki H, Yamada N, Shimano H
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 31
Pages: 1788-95
Related Report
Peer Reviewed
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[Presentation] Sterol regulatory element-binding protein-1 is involved in the development of angiotensin II-induced cardiac fibrosis.2012
Author(s)
Sakai S, Nakagawa N, Shimojo N, Kumura T, Tajiri K, Kuga K, Homma S, Miyauchi T, Aonuma K, Shimano H
Organizer
Basic Cardiovascular Sciences Conference
Place of Presentation
New Orleans, USA
Year and Date
2012-07-24
Related Report
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