| Project/Area Number |
23659287
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | University of Shizuoka |
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Principal Investigator |
YAMADA Shizuo 静岡県立大学, 薬学部, 教授 (80106434)
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| Co-Investigator(Renkei-kenkyūsha) |
WATANABE Hiroshi 浜松医科大学, 医学部, 教授 (50262803)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 緑茶 / カテキン類 / シンバスタチン / 相互作用 / 薬物代謝酵素 / シトクロームP-450 / スタチン剤 / 日本人 / 血漿中濃度 / 体内動態 / 緑茶カテキン / 血漿中薬物濃度 / 薬物動態 |
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| Research Abstract |
The present study aimed to evaluate the effect of catechin-rich green tea consumption on the pharmacokinetics of simvastatin lactone (SIM) and simvastatin acid (SVA). A single oral dose of SIM was administered to healthy Japanese male volunteers after drinking of green tea or water for 2 weeks. Blood samples were collected up to 24 h after the administration. Plasma concentrations of SIM and SVA were determined. Pharmacokinetic parameters were estimated by non-compartmental analysis. Chronic consumption of catechin-rich green tea increased the area under the plasma concentration-time curve (AUC) and maximum concentration (Cmax) of SIM. It also inhibited CYP enzymes in the liver. Thus, the chronic consumption of catechin-rich green tea may cause the clinically relevant interaction with simvastatin.
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