Translational research of phama and food by greentea
| Project/Area Number |
23659287
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | University of Shizuoka |
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Principal Investigator |
YAMADA Shizuo 静岡県立大学, 薬学部, 教授 (80106434)
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| Co-Investigator(Renkei-kenkyūsha) |
WATANABE Hiroshi 浜松医科大学, 医学部, 教授 (50262803)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 緑茶 / カテキン類 / シンバスタチン / 相互作用 / 薬物代謝酵素 / シトクロームP-450 / スタチン剤 / 日本人 / 血漿中濃度 / 体内動態 / 緑茶カテキン / 血漿中薬物濃度 / 薬物動態 |
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| Research Abstract |
The present study aimed to evaluate the effect of catechin-rich green tea consumption on the pharmacokinetics of simvastatin lactone (SIM) and simvastatin acid (SVA). A single oral dose of SIM was administered to healthy Japanese male volunteers after drinking of green tea or water for 2 weeks. Blood samples were collected up to 24 h after the administration. Plasma concentrations of SIM and SVA were determined. Pharmacokinetic parameters were estimated by non-compartmental analysis. Chronic consumption of catechin-rich green tea increased the area under the plasma concentration-time curve (AUC) and maximum concentration (Cmax) of SIM. It also inhibited CYP enzymes in the liver. Thus, the chronic consumption of catechin-rich green tea may cause the clinically relevant interaction with simvastatin.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Effects of Green Tea Catechins on Cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A Activities in Human Liver and Intestinal Microsomes2013
Author(s)
Shingen Misaka, Keisuke Kawabe, Satomi Onoue, Jose Pablo Werba, Monica Giroli, Sekihiro Tamaki, Toshiyuki Kan, Junko Kimura, Hiroshi Watanabe, Shizuo Yamada
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Journal Title
Drug Metab. Pharmacokinet
Volume: 28
Pages: 244-9
NAID
Related Report
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[Journal Article] Effects of Green Tea Catechins on Cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A Activities in Human Liver and Intestinal Microsomes2013
Author(s)
22. Shingen Misaka, Keisuke Kawabe, Satomi Onoue, José Pablo Werba, Monica Giroli, Sekihiro Tamaki, Toshiyuki Kan, Junko Kimura, Hiroshi Watanabe, Shizuo Yamada
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Journal Title
Drug Metab. Pharmacokinet.
Volume: 28
Pages: 244-249
NAID
Related Report
Peer Reviewed
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[Journal Article] Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6, and 3A activities in human liver and intestinal microsomes.2013
Author(s)
Shingen Misaka,Keisuke Kawabe,Satomi Onoue,Jose Pablo Werba,Monica Giroli,Sekimoto Tamaki,Toshiyuki Kan,Junko Kimura, Hiroshi Watanabe,Shizuo Yamada
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Journal Title
Drug Metab Pharmacokinet
Volume: in press
NAID
Related Report
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