Project/Area Number |
23659303
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Laboratory medicine
|
Research Institution | Kumamoto University |
Principal Investigator |
ANDO Yukio 熊本大学, 大学院・生命科学研究部, 教授 (20253742)
|
Co-Investigator(Kenkyū-buntansha) |
OBAYASHI Konen 熊本大学, 医学部附属病院, 特任教授 (90361899)
JONO Hirofumi 熊本大学, 医学部附属病院, 准教授 (40515483)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | ミスフォールディング病 / トランスサイレチン / アミロイドーシス / ミスフォールディング / 自己抗体 / エピトープ / 家族性アミロイドポリニューロパチー / 遺伝子変異 / 臨床検査医学 / FAP |
Research Abstract |
We examined presence or absence of anti-variant transthyretin (TTR) antibody in both transgenic rats and familial amyloidotic polyneuropathy (FAP ATTR V30M). In significant numbers of Japanese and Swedish FAP patients, the antibody was present. All patients were late onset cases. As epitopes of TTR variant, ATTR24-35, and 105-115 were listed. When we consider the novel therapy for FAP, this findings are very important and give some hint for the essential therapy.
|