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Classification of hematologic malignancy by relationship between cancer and expression of human cellular phosphoprotein.

Research Project

Project/Area Number 23659304
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Laboratory medicine
Research InstitutionBunkyo Gakuin University

Principal Investigator

MOTOFUJI Yoko  文京学院大学, 保健医療技術学部, 助手 (00458556)

Co-Investigator(Renkei-kenkyūsha) KOMATSU Hiroyoshi  文京学院大学, 大学院・保健医療科学研究科, 教授 (30170377)
KOIKE Morio  文京学院大学, 大学院・保健医療科学研究科, 教授 (00089989)
KODERA Yoshio  北里大学, 大学院・理学研究科, 准教授 (60265733)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsモノクローナル抗体 / リン酸化蛋白質 / 腫瘍検査 / プロテオーム / 血液悪性腫瘍
Research Abstract

On the basis of the reaction of the human leukemia cell lines with anti - phosphoprotein monoclonal antibodies, the reactivity of anti - phosphoprotein monoclonal antibodies was in vestigated using cells of hematologic malignancy. The 110 anti-phosphoprotein monoclonal antibodiesreacted with reactivity to formalin-fi xedtissuesandcells . A part of them had tumor specificity by immunohistochemical staining; the specificity of anti - phosphoprotein monoclonal antibody was identified by proteomics. To investigate the relationship between antigen molecule and leukemia c lassification, the effect of staining in hematology and of anticancer agents towards leukemia cell lines were examined . As he results , the antigen molecules anti - phosphoprotein monoclonal antibodies recognized related to the response of the anticancer agents towards T cell leukemia.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (8 results)

All 2012

All Journal Article (8 results) (of which Peer Reviewed: 4 results)

  • [Journal Article] 抗リン酸化蛋白質抗体が認識する新たな腫瘍特異抗原の探索と同定(II)2012

    • Author(s)
      小松博義 、小寺義男 、元藤陽子
    • Journal Title

      文京学院大学総合研究所紀要

      Volume: 第13号 Pages: 229-238

    • Related Report
      2012 Final Research Report
  • [Journal Article] Potential of classification of cancerby multiple discriminant analysis for relationship between cancer and expression of hum ancellular phosphoprotein2012

    • Author(s)
      Motofuji Y , Saito A ,Koike M ,Kodera Y , Maeda T , Komatsu H
    • Journal Title

      Biomedical Research

      Volume: Vol.33 Pages: 139-143

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 新規がんプロテオミクスの開発「抗リン酸化蛋白質モノクローナル抗体群による新規疾患診断法」2012

    • Author(s)
      元藤陽子
    • Journal Title

      北里大学大学院理学研究科

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 抗リン酸化蛋白質抗体が認識する新たな腫瘍特異抗原の探索と同定(I)2012

    • Author(s)
      元藤陽子、小寺義男、小松博義
    • Journal Title

      文京学院大学総合研究所紀要

      Volume: 第12号 Pages: 245-252

    • Related Report
      2012 Final Research Report
  • [Journal Article] Potential of classification of cancer by multiple discriminant analysis for relationship between cancer and expression of human cellular phosphoprotein.2012

    • Author(s)
      元藤 陽子
    • Journal Title

      Biomedical Research

      Volume: 33 Pages: 139-143

    • NAID

      130004470809

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 抗リン酸化蛋白質抗体が認識する新たな腫瘍特異抗原の探索と同定(II)2012

    • Author(s)
      小松 博義
    • Journal Title

      文京学院大学総合研究所紀要

      Volume: 13 Pages: 229-238

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 抗リン酸化蛋白質抗体が認識する新たな腫瘍特異抗原の探索と同定I「Blue Native-Polyacrylamide Gel Electrophoresisの基礎的検討」2012

    • Author(s)
      元藤 陽子
    • Journal Title

      文京学院大学総合研究所紀要

      Volume: 12 Pages: 245-252

    • Related Report
      2011 Research-status Report
  • [Journal Article] 新規がんプロテオミクスの開発「抗リン酸化蛋白質モノクローナル抗体群による新規疾患診断法」2012

    • Author(s)
      元藤 陽子
    • Journal Title

      北里大学大学院理学研究科 後期博士課程 博士論文

      Volume: -

    • Related Report
      2011 Research-status Report
    • Peer Reviewed

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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