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Establishment of a strategy for the detection of disease-related modification of proteins in serum

Research Project

Project/Area Number 23659305
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Laboratory medicine
Research InstitutionKitasato University

Principal Investigator

KODERA Yoshio  北里大学, 理学部物理学科, 准教授 (60265733)

Co-Investigator(Renkei-kenkyūsha) MAEDA Tadakazu  北里大学, 名誉教授 (90265728)
NOMURA Fumio  千葉大学, 医学研究院, 教授 (80164739)
GOJIMA Naoki  (独)産業技術総合研究所生物情報解析研究センター, 主任研究員 (70215482)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords臨床検査医学 / 血中診断マーカー / タンパク質 / 機能状態 / 血清 / 定量分析 / 翻訳語修飾 / 診断マーカー
Research Abstract

Modifications of protein such as post-translational modification, cleavage and alternative splicing are caused by disease. In this study, we have developed the strategy to detect disease-related protein modification in serum.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (61 results)

All 2013 2012 2011 Other

All Journal Article (41 results) (of which Peer Reviewed: 41 results) Presentation (18 results) (of which Invited: 4 results) Book (1 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Enhanced recovery of lyophilized peptides in shotgun proteomics by using an LC-ESI-MS compatible surfactant2013

    • Author(s)
      Kawashima Y, Takahashi N, Satoh M, Saito T, Kado S, Nomura F, Matsumoto H, Kodera Y
    • Journal Title

      Proteomics

      Volume: 13(5) Pages: 751-5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment and application of a high-quality comparative analysis strategy for the discovery and small-scale validation of low-abundance biomarker peptides in serum based on an optimized novel peptide extraction method2013

    • Author(s)
      Saito T, Kawashima Y, Minamida S, Matsumoto K, Araki K, Matsui T, Satoh M, Nomura F, Iwamura M, Maeda T, Baba S, Kodera Y
    • Journal Title

      Journal of Electrophoresis

      Volume: 57 Issue: 1 Pages: 1-9

    • DOI

      10.2198/jelectroph.57.1

    • NAID

      130003364779

    • ISSN
      1349-9394, 1349-9408
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Application of quantitative proteomic analysis using tandem mass tags for discovery and identification of novel biomarkers in periodontal disease2013

    • Author(s)
      Tsuchida S, Satoh M, Kawashima Y, Sogawa K, Kado S, Sawai S, Nishimura M, Ogita M, Takeuchi Y, Kobyashi H, Aoki A, Kodera Y,Matsushita K, Izumi Y, Nomura F
    • Journal Title

      Proteomics

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum monomeric α2-macroglobulin as a clinical biomarker in diabetes2013

    • Author(s)
      Takada T, Kodera Y, Matsubara M, Kawashima Y, Maeda T, Fujita Y, Shichiri M
    • Journal Title

      Atherosclerosis

      Volume: 228(1) Pages: 270-6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclic sample pooling using two-dimensional liquid chromatography system enhances coverage in shotgun proteomics2013

    • Author(s)
      Kawashima Y, Satoh M, Saito T, Matsui T, Nomura F, Matsumoto H, Kodera Y
    • Journal Title

      Biomed Chromatogr

      Volume: 27(6) Pages: 691-4

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oryziaslatipes, as a model for human obesity-related glomerulopathy2013

    • Author(s)
      Ichimura K, Kawashima Y, Nakamura T, Powell R, Hidoh Y, Terai S, Sakaida I,Kodera Y, Tsuji T, Ma JX, Sakai T, Matsumoto H, Obara T. Medaka
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 431(4) Pages: 712-7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Integrated view of the humanchromosome X-centric proteome project2013

    • Author(s)
      Yamamoto T, Nakayama K, Hirano H, Tomonaga T, Ishihama Y, Yamada T, Kondo T,Kodera Y, Sato Y, Araki N, Mamitsuka H, Goshima N
    • Journal Title

      J Proteome Res

      Volume: 12(1) Pages: 58-61

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin-converting enzymeinhibition curbs tyrosine nitration of mitochondrial proteins in the renal cortexduring the early stage of diabetes mellitus in rats2013

    • Author(s)
      Ishii N, Carmines PK, Yokoba M, Imaizumi H, Ichikawa T, Ikenagasa H, Kodera Y,Oh-Ishi M, Aoki Y, Maeda T, Takenaka T, Katagiri M
    • Journal Title

      Clin Sci (Lond)

      Volume: 124(8) Pages: 543-52

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preanalytical evaluation of serum 25-hydroxyvitamin D3 and25-hydroxyvitamin D2 measurements using LC-MS/MS2013

    • Author(s)
      Mochizuki A, Kodera Y, Saito T, Satoh M, Sogawa K, Nishimura M, Seimiya M, Kubota M, Nomura F
    • Journal Title

      Clin Chim Acta

      Volume: 420 Pages: 114-20

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced recovery of lyophilized peptides in shotgun proteomics by using an LC-ESI-MS compatible surfactant2013

    • Author(s)
      Kawashima Y, Takahashi N, Satoh M, Saito T, Kado S, Nomura F, Matsumoto H, Kodera Y
    • Journal Title

      Proteomics

      Volume: 13 Issue: 5 Pages: 751-755

    • DOI

      10.1002/pmic.201200462

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclic sample pooling using two-dimensional liquid chromatography system enhances coverage in shotgun proteomics2013

    • Author(s)
      Kawashiraa Y, Satoh M, Saito T, Matsui T, Nomura F, Matsumoto H, Kodera Y
    • Journal Title

      Biomedical Chromatography

      Volume: 27 Issue: 6 Pages: 691-694

    • DOI

      10.1002/bmc.2864

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preanalytical evaluation of serum 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 measurements using LC-MS/MS.2013

    • Author(s)
      Mochizuki A, Kodera Y, Saito T, Satoh M, Sogawa K, Nishimura M, Seimiya M,Kubota M, Nomura F.
    • Journal Title

      Clin Chim Acta.

      Volume: 420 Pages: 114-120

    • DOI

      10.1016/j.cca.2012.10.041

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum monomeric α2-macroglobulin as a clinical biomarker in diabetes.2013

    • Author(s)
      Takada T, Kodera Y, Matsubara M, Kawashima Y, Maeda T, Fujita Y, Shichiri M.
    • Journal Title

      Atherosclerosis.

      Volume: 228 Issue: 1 Pages: 270-276

    • DOI

      10.1016/j.atherosclerosis.2013.02.035

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Medaka fish, Oryzias latipes, as a model for human obesity-related glomerulopathy.2013

    • Author(s)
      Ichimura K, Kawashima Y, Nakamura T, Powell R, Hidoh Y, Terai S, Sakaida I, Kodera Y, Tsuji T, Ma JX, Sakai T, Matsumoto H, Obara T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 431 Pages: 712-717

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integrated view of the human chromosome X-centric proteome project.2013

    • Author(s)
      Yamamoto T, Nakayama K, Hirano H, Tomonaga T, Ishihama Y, Yamada T, Kondo T,Kodera Y, Sato Y, Araki N, Mamitsuka H, Goshima N.
    • Journal Title

      J Proteome Res.

      Volume: 12 Issue: 1 Pages: 58-61

    • DOI

      10.1021/pr300844p

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin-converting enzyme inhibition curbs tyrosine nitration of mitochondrial proteins in the renal cortex during the early stage of diabetes mellitus in rats.2013

    • Author(s)
      Ishii N, Carmines PK, Yokoba M, Imaizumi H, Ichikawa T, Ikenagasa H, Kodera Y,Oh-Ishi M, Aoki Y, Maeda T, Takenaka T, Katagiri M.
    • Journal Title

      Clin Sci (Lond).

      Volume: 124 Issue: 8 Pages: 543-552

    • DOI

      10.1042/cs20120251

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A strategy for large-scale phosphoproteomics and SRM-based validation of human breast cancer tissue samples2012

    • Author(s)
      Narumi R, Murakami T, Kuga T, Adachi J, Shiromizu T, Muraoka S, Kume H, Kodera Y, Matsumoto M, Nakayama K, Miyamoto Y, Ishitobi M, Inaji H, Kato K, Tomonaga T
    • Journal Title

      J Proteome Res

      Volume: 11(11) Pages: 5311-22

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The application of a three-step serum proteome analysis for the discovery andidentification of novel biomarkers of hepatocellular carcinoma2012

    • Author(s)
      Kimura A, Sogawa K, Satoh M, Kodera Y, Yokosuka O, Tomonaga T, Nomura F
    • Journal Title

      Int J Proteomics

      Volume: 2012 Pages: 623190-623190

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a Novel Biomarker for Biliary Tract Cancer Using Matrix-Assisted Laser Desorption/Ionization Time-of-FlightMass Spectrometry2012

    • Author(s)
      Kikkawa S, Sogawa K, Satoh M, Umemura H, Kodera Y, Matsushita K, Tomonaga T, Miyazaki M, Yokosuka O, Nomura F
    • Journal Title

      Int J Proteomics

      Volume: 2012 Pages: 108609-108609

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Strategy for SRM-basedverification of biomarker candidates discovered by iTRAQ method in limited breast cancer tissue samples2012

    • Author(s)
      Muraoka S, Kume H, Watanabe S, Adachi J, Kuwano M, Sato M, Kawasaki N, Kodera Y,Ishitobi M, Inaji H, Miyamoto Y, Kato K, Tomonaga T
    • Journal Title

      J Proteome Res

      Volume: 11(8) Pages: 4201-10

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic analysis of gingivalcrevicular fluid for discovery of novel periodontal disease markers2012

    • Author(s)
      Tsuchida S, Satoh M, Umemura H, Sogawa K, Kawashima Y, Kado S, Sawai S,Nishimura M, Kodera Y, Matsushita K, Nomura F
    • Journal Title

      Proteomics

      Volume: 12(13) Pages: 2190-202

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potential ofclassification of cancer by multiple discriminant analysis for relationshipbetween cancer and expression of human cellular phosphoprotein2012

    • Author(s)
      Motofuji Y, Saito A, Koike M, Kodera Y, Maeda T, Komatsu H
    • Journal Title

      Biomed Res

      Volume: 33(2) Pages: 139-43

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plectin promotes migration and invasion of cancer cells and is a novel prognostic marker for head and neck squamous cell carcinoma2012

    • Author(s)
      Katada K, Tomonaga T, Satoh M, Matsushita K, Tonoike Y, Kodera Y, Hanazawa T, Nomura F, Okamoto Y
    • Journal Title

      J Proteomics

      Volume: 75(6) Pages: 1803-15

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A strategy for large-scale phosphoproteomics and SRM-based validation of human breast cancer tissue samples.2012

    • Author(s)
      Narumi R, Murakami T, Kuga T, Adachi J, Shiromizu T, Muraoka S, Kume H, Kodera Y, Matsumoto M, Nakayama K, Miyamoto Y, Ishitobi M, Inaji H, Kato K, Tomonaga T.
    • Journal Title

      J Proteome Res.

      Volume: 11 Issue: 11 Pages: 5311-5322

    • DOI

      10.1021/pr3005474

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The application of a three-step serum proteome analysis for the discovery and identification of novel biomarkers of hepatocellular carcinoma.2012

    • Author(s)
      Kimura A, Sogawa K, Satoh M, Kodera Y, Yokosuka O, Tomonaga T, Nomura F.
    • Journal Title

      Int J Proteomics.

      Volume: 2012: Pages: 623190-623190

    • DOI

      10.1155/2012/623190

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Strategy for SRM-based verification of biomarker candidates discovered by iTRAQ method in limited breast cancer tissue samples.2012

    • Author(s)
      Muraoka S, Kume H, Watanabe S, Adachi J, Kuwano M, Sato M, Kawasaki N, Kodera Y, Ishitobi M, Inaji H, Miyamoto Y, Kato K, Tomonaga T.
    • Journal Title

      J Proteome Res.

      Volume: 11 Issue: 8 Pages: 4201-4210

    • DOI

      10.1021/pr300322q

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic analysis of gingival crevicular fluid for discovery of novel periodontal disease markers.2012

    • Author(s)
      Tsuchida S
    • Journal Title

      Proteomics.

      Volume: 12(13) Issue: 13 Pages: 2190-202

    • DOI

      10.1002/pmic.201100655

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential of classification of cancer by multiple discriminant analysis for relationship between cancer and expression of human cellular phosphoprotein.2012

    • Author(s)
      Motofuji Y, Saito A, Koike M, Kodera Y, Maeda T, Komatsu H.
    • Journal Title

      Biomed Res.

      Volume: 33 Pages: 139-143

    • NAID

      130004470809

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plectin promotes migration and invasion of cancer cells and is a novel prognostic marker for head and neck squamous cell carcinoma.2012

    • Author(s)
      Katada K, Tomonaga T, Satoh M, Matsushita K, Tonoike Y, Kodera Y, Hanazawa T,Nomura F, Okamoto Y.
    • Journal Title

      J Proteomics.

      Volume: 75 Issue: 6 Pages: 1803-1815

    • DOI

      10.1016/j.jprot.2011.12.018

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 14-3-3 protein beta/alpha as a urinary biomarker forrenal cell carcinoma: proteomic analysis of cyst fluid2011

    • Author(s)
      Minamida S, Iwamura M, Kodera Y, Kawashima Y, Tabata K, Matsumoto K, FujitaT, Satoh T, Maeda T, Baba S
    • Journal Title

      Anal Bioanal Chem

      Volume: 401(1) Pages: 245-52

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a sandwich ELISA for the 5.9-kDa fibrinogen alpha C chain fragment detected by serum proteome analysis2011

    • Author(s)
      Noda K, Sogawa K, Kikuchi W, Kiyokawa I, Miura T, Kojima R, Katayama K, Kodera Y, Nomura F
    • Journal Title

      Proteomics Clin Appl

      Volume: 5(3-4) Pages: 141-6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The measurement of a fibrinogen a C-chain 5.9 kDa fragment (FIC 5.9) using MALDI-TOF MS and a stable isotope-labeled peptidestandard dilution2011

    • Author(s)
      Sogawa K, Kodera Y, Noda K, Ishizuka Y, Yamada M, Umemura H, Maruyama K, Tomonaga T, Yokosuka O, Nomura F
    • Journal Title

      Clin Chim Acta

      Volume: 412(11-12) Pages: 1094-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Profilin 1 overexpression in renal cell carcinoma2011

    • Author(s)
      Minamida S, Iwamura M, Kodera Y, Kawashima Y, Ikeda M, Okusa H, Fujita T,Maeda T, Baba S
    • Journal Title

      Int J Urol

      Volume: 18(1) Pages: 63-71

    • NAID

      10027902072

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased serum levels of pigment epithelium-derived factor by excessive alcohol consumption-detection and identification by a three-step serum proteome analysis2011

    • Author(s)
      Sogawa K, Kodera Y, Satoh M, Kawashima Y, Umemura H, Maruyama K, Takizawa H, Yokosuka O, Nomura F
    • Journal Title

      Alcohol Clin Exp Res

      Volume: 35(2) Pages: 211-7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum Level of Fibrinogen Aα Chain Fragment Increases in Chronic Thromboembolic Pulmonary Hypertension.2011

    • Author(s)
      Yano T, Sogawa K, Umemura H, Sakao S, Kasahara Y, Tanabe N, Kodera Y, Takiguchi Y, Tatsumi K, Nomura F.
    • Journal Title

      Circ J. 75

      Volume: 75 Pages: 2675-2682

    • NAID

      10030032528

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 14-3-3 protein beta/alpha as a urinary biomarker for renal cell carcinoma: proteomic analysis of cyst fluid.2011

    • Author(s)
      Minamida S, Iwamura M, Kodera Y, Kawashima Y, Tabata K, Matsumoto K, Fujita T, Satoh T, Maeda T, Baba S.
    • Journal Title

      Anal Bioanal Chem.

      Volume: 401 Pages: 245-252

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of a sandwich ELISA for the 5.9-kDa fibrinogen alpha C chain fragment detected by serum proteome analysis2011

    • Author(s)
      Noda K, Sogawa K, Kikuchi W, Kiyokawa I, Miura T, Kojima R, Katayama K, Kodera Y, Nomura F
    • Journal Title

      Proteomics Clin Appl

      Volume: 5 Issue: 3-4 Pages: 141-146

    • DOI

      10.1002/prca.201000127

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The measurement of a fibrinogen α C-chain 5.9 kDa fragment (FIC 5.9) using MALDI-TOF MS and a stable isotope-labeled peptide standard dilution.2011

    • Author(s)
      Sogawa K, Kodera Y, Noda K, Ishizuka Y, Yamada M, Umemura H, Maruyama K, Tomonaga T, Yokosuka O, Nomura F.
    • Journal Title

      Clin Chim Acta.

      Volume: 412 Pages: 1094-1099

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of a high molecular weight kininogen fragment as a marker for early gastric cancer by serum proteome analysis.2011

    • Author(s)
      Umemura H, Togawa A, Sogawa K, Satoh M, Mogushi K, Nishimura M, Matsushita K, Tanaka H, Takizawa H, Kodera Y, Nomura F.
    • Journal Title

      J Gastroenterol.

      Volume: 46 Pages: 577-585

    • NAID

      10029028943

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Profilin 1 overexpression in renal cell carcinoma2011

    • Author(s)
      Minamida S, Iwamura M, Kodera Y, Kawashima Y, Ikeda M, Okusa H, Fujita T, Maeda T, Baba S
    • Journal Title

      Int J Urol

      Volume: 18 Issue: 1 Pages: 63-71

    • DOI

      10.1111/j.1442-2042.2010.02670.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increased serum levels of pigment epithelium-derived factor by excessive alcohol consumption-detection and identification by a three-step serum proteome analysis2011

    • Author(s)
      Sogawa K, Kodera Y, Satoh M, Kawashima Y, Umemura H, Maruyama K, Takizawa H, Yokosuka O, Nomura F
    • Journal Title

      Alcohol Clin Exp Res

      Volume: 35 Issue: 2 Pages: 211-217

    • DOI

      10.1111/j.1530-0277.2010.01336.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 血中診断マーカーペプチド獲得を目指したペプチドーム解析法の包括的な開発2012

    • Author(s)
      小寺義男
    • Organizer
      第19回遺伝子診療学会/シンポジウム
    • Place of Presentation
      千葉
    • Year and Date
      2012-07-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 血中診断マーカーペプチド獲得を目指した ペプチドーム解析法の包括的な開発2012

    • Author(s)
      小寺義男
    • Organizer
      第10回日本プロテオーム学会(JHUPO)年会(シンポジウム)
    • Place of Presentation
      東京
    • Year and Date
      2012-07-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 血中疾患マーカーペプチド獲得を目指した包括的なアプローチ2012

    • Author(s)
      小寺義男
    • Organizer
      東北大学医学部・最先端学術セミナー
    • Place of Presentation
      東北大学医学部(招待講演)
    • Year and Date
      2012-06-15
    • Related Report
      2012 Final Research Report
  • [Presentation] High quality method for discovery and verification of low abundance biomarker peptides in serum2012

    • Author(s)
      "Yoshio Kodera Tatsuya Saito, Yusuke Kawashima, Satoru Minamida, Kazumasa Matsumoto, Keita Araki, Takashi Matsui, Mamoru Satoh, Fumio Nomura,Masatsugu Iwamura, Shiro Baba ,Tadakazu Maeda
    • Organizer
      AOHUPO(Asia Oceania HUman Proteomics Organization)
    • Place of Presentation
      北京/中国
    • Related Report
      2012 Annual Research Report
  • [Presentation] 血中診断マーカーペプチド獲得を目指した ペプチドーム解析法の包括的な開発2012

    • Author(s)
      "小寺義男,川島祐介,斎藤達也,佐藤守 ,曽川一幸 ,前田忠計 ,朝長毅 ,野村文夫
    • Organizer
      第10回日本プロテオーム学会(JHUPO)年会/シンポジウム
    • Place of Presentation
      日本科学未来館(東京)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 血中診断マーカーペプチド獲得を目指したペプチドーム解析法の包括的な開発2012

    • Author(s)
      小寺義男
    • Organizer
      第19回遺伝子診療学会/シンポジウム
    • Place of Presentation
      三井ガーデンホテル千葉
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Comprehensive approach to develop diagnostic biomarker peptides in serum –Establishment of discovery and validation methods targeting low-abundance peptides–2012

    • Author(s)
      Yoshio Kodera,Tatsuya Saitoh,Yusuke Kawashima, Kazuyuki Sogawa, Satoru Minamida, Kazumasa Matsumoto, Masatsugu Iwamura, Shiro Baba,Tadakazu Maeda,Takeshi Tomonaga,Fumio Nomura
    • Organizer
      HUPO 2012 11th World Congress
    • Place of Presentation
      ボストン(USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 血中診断マーカーペプチド提案を目指した 探索ならびに多検体評価法の包括的な開発2012

    • Author(s)
      "小寺義男,川島祐介,斎藤達也,佐藤守 ,曽川一幸 ,前田忠計 ,朝長毅,野村文夫
    • Organizer
      第85回 日本生化学会
    • Place of Presentation
      福岡国際会議場、マリンメッセ福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 血中診断マーカーペプチド獲得を目指した包括的なアプローチ2011

    • Author(s)
      小寺義男
    • Organizer
      第2回バイオビジネス・スタートアップ -バイオマーカー研究と診断への応用-
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 血中診断マーカーペプチド開発に向けた様々なアプローチ2011

    • Author(s)
      小寺義男
    • Organizer
      第224回液体クロマトグラフィー研究懇談会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-25
    • Related Report
      2012 Final Research Report
  • [Presentation] 共同利用における LC-MS 解析2011

    • Author(s)
      小寺義男
    • Organizer
      第84回日本生化学会・フォーラム(フォーラム企画、発表)
    • Place of Presentation
      京都
    • Year and Date
      2011-09-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 血中診断マーカー獲得を目指した定量的プロテオミクス2011

    • Author(s)
      小寺義男
    • Organizer
      日本プロテオーム学会 2011 大会(シンポジウム)
    • Place of Presentation
      新潟
    • Year and Date
      2011-07-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 血中診断マーカー獲得を目指した定量的プロテオミクス2011

    • Author(s)
      小寺 義男
    • Organizer
      日本プロテオーム学会2011大会・シンポジウム(招待講演)
    • Place of Presentation
      新潟
    • Related Report
      2011 Research-status Report
  • [Presentation] 共同利用におけるLC-MS解析2011

    • Author(s)
      小寺 義男
    • Organizer
      第84回日本生化学会・フォーラム(招待講演)
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] 血中診断マーカーペプチド開発に向けた様々なアプローチ2011

    • Author(s)
      小寺義男
    • Organizer
      第244回液体クロマトグラフィー研究懇談会(招待講演)
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 血中診断マーカーペプチド獲得を目指した包括的なアプローチ2011

    • Author(s)
      小寺義男
    • Organizer
      第2回バイオビジネス・スタートアップ  -バイオマーカー研究と診断への応用-(招待講演)
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] Comprehensive approach to develop diagnostic biomarker peptides in serum. –Establishment of discovery and validation methods targeting low-abundance peptides–

    • Author(s)
      Yoshio Kodera
    • Organizer
      RCAI Seminar Series 2012
    • Place of Presentation
      (独)理化学研究所・免疫アレルギー科学総合研究センター(RCAI)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 血中疾患マーカーペプチド獲得を目指した包括的なアプローチ

    • Author(s)
      小寺義男
    • Organizer
      東北大学医学部・最先端学術セミナー
    • Place of Presentation
      東北大学医学部
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] 臨床プロテオミクス-バイオマーカー探索から個別化医療へ-, 第3 章 臨床試料の取り扱い「2.血液(血漿)および生体試液」2012

    • Author(s)
      小寺義男,朝長毅
    • Publisher
      金原出版株式会社
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] METHOD FOR CONCENTRATION OF LOW-MOLECULAR-WEIGHT PROTEINS AND PEPTIDES IN BODY FLUID SAMPLE2013

    • Inventor(s)
      Kodera Y. Kawashima Y. Maeda T
    • Industrial Property Rights Holder
      The Kitasato Institute
    • Filing Date
      2013-03-19
    • Related Report
      2012 Final Research Report
    • Overseas

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Published: 2011-08-05   Modified: 2019-07-29  

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