Establishment of simple methodology on clinical monitoring for gastric cancer
| Project/Area Number |
23659308
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Showa University |
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Principal Investigator |
ITO HIROAKI 昭和大学, 医学部, 講師 (70443447)
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| Co-Investigator(Kenkyū-buntansha) |
KUDO Shin-ei 昭和大学, 医学部, 教授 (70161643)
INOUE Haruhiro 昭和大学, 医学部, 教授 (90280966)
SANDO Norimasa 昭和大学, 医学部, 兼任講師 (50602116)
木村 聡 昭和大学, 医学部, 准教授 (30255765)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 腫瘍検査学 / 循環癌細胞 / 胃癌 / 癌 / ゲノムDNA / 網羅的遺伝子解析 / 次世代シークエンサー |
|---|
| Research Abstract |
Methods: We obtained peripheral blood samples from 65 patients with gastric cancer. After infection of OBP-401, GFP-positive (GFP+) cells were counted and measured. The relationship between the number of GFP+ cells and surgical outcome was analyzed.
Results: The median follow-up period of the surviving patients was 36 months. A significant difference in overall survival was found between patients with 0-5 and patients with 6 or more large-sized GFP+ cells (L-GFP+ cells). No clear relationship was established between the number of small-sized GFP+ cells and patients' prognosis.
Conclusions: The number of L-GFP+ cells was significantly related to overall survival in patients with gastric cancer. The detection of L-GFP+ cells using OBP-401 may be a useful prognostic marker in gastric cancer.
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Report
(4 results)
Research Products
(29 results)
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[Presentation] Circulating tumor cells on gastrointestinal malignancies2013
Author(s)
Hiroaki Ito, Haruhiro Inoue, Satoshi Kimura, Manabu Onimaru, Haruo Ikeda, and Shin-ei Kudo
Organizer
5th Annual International Forum : Regional & Targeting Therapies Cancer (RTTC 2013), Session 12 : Circulating Tumor Cells and Cancer Stem Cells from Research to Clinic
Place of Presentation
Shanghai, China
Related Report
Invited
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[Presentation] OBP-401 を用いた胃癌患者末梢血中循環癌細胞検出と予後との相関2012
Author(s)
伊藤寛晃,井上晴洋, 山洞典正, 木村聡, 合田圭吾,伊藤俊, 里舘均, 小鷹紀子, 池田晴夫, 工藤進英
Organizer
第84回日本胃癌学会,ワークショップ3 微小転移の臨床的意義と臨床応用の可能性
Place of Presentation
大阪
Year and Date
2012-02-09
Related Report
Invited
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[Presentation] 循環癌細胞の個別採取と増幅抽出ゲノムDNA の次世代シークエンサーによる網羅的遺伝子解析2012
Author(s)
伊藤寛晃, 井上晴洋,山洞典正, 木村聡, 大森亨, 小鷹紀子, 里舘均, 鈴木道隆, 木田裕之, 工藤進英
Organizer
第113回日本外科学会総会, 新規治療法開発遺伝子解析
Place of Presentation
福岡
Related Report
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[Presentation] 癌細胞検出技術と臨床応用 : 胃癌循環癌細胞前向き試験の途中成績と次世代技術2011
Author(s)
伊藤寛晃, 井上晴洋, 山洞典正, 木村聡,合田圭吾, 佐藤淳, 村上克洋, 伊藤俊, 前田知世, 小鷹紀子, 里舘均, 池田晴夫,Nikolas Eleftheriadis, Roberta Maselli,鬼丸学, 吉田亮, 細谷寿久, 須藤晃佑, 工藤進英
Organizer
第41回神奈川胃癌治療研究会
Place of Presentation
横浜
Year and Date
2011-12-17
Related Report
Invited
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[Presentation] 循環癌細胞と臨床応用2011
Author(s)
伊藤寛晃, 井上晴洋, 山洞典正, 木村聡, 合田圭吾, 佐藤淳, 村上克洋, 伊藤俊, 前田知世, 里舘均,小鷹紀子, 池田晴夫, 工藤進英
Organizer
第272回新潟外科集談会
Place of Presentation
新潟
Year and Date
2011-12-03
Related Report
Invited
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