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Developing the high sensitive immunochromatograhy with a newl method for improving immunofluorescent signals

Research Project

Project/Area Number 23659314
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Laboratory medicine
Research InstitutionTokyo Metropolitan Institute of Medical Science

Principal Investigator

SHIBASAKI Futoshi  公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 参事研究員 (90300954)

Co-Investigator(Kenkyū-buntansha) SAKURAI Akira  公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員 (40546628)
ENDO Fumiko  公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員 (80546630)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords診断 / 蛍光 / イムノクロマト / インフルエンザ / 子宮頚癌 / 鳥インフルエンザ / H5N1 / ワクチン / 子宮頸がん / 抗体
Research Abstract

In this study, we focused on the specific aim to develop the fluorescent enhancement methods (IMPACTag) for improving the MUSTag sensitivity and also apply this methods to Immunochromatography and the devices.
First, we tried to develop the IMPACTag, but the sensitivity was not enough to our goal, and we changed the strategy to use fluorescent beads instead of IMPACTag. During our research term, we succeeded in developing the high sensitive immunochromatography (IC) tips and the device in collaboration with companies. For detection of influenza viruses, the IC chip and the device could detect viruses 100 fold more sensitive than conventional methods. Furthermore, we also succeeded in the developing the assay system for detecting antibodies against papilloma virus L1 proteins. the system will be available for the evaluation of the cervical cancer vaccine effect after the inoculation.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (62 results)

All 2013 2012 2011 Other

All Journal Article (21 results) (of which Peer Reviewed: 19 results,  Open Access: 1 results) Presentation (32 results) (of which Invited: 7 results) Book (3 results) Remarks (4 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Protein-based open sandwich immuno-PCR for sensitive detection of small biomarkers2013

    • Author(s)
      S. Hasan, J. Dong, Y. Hara, Y. Morizane, F. Shibasaki and H. Ueda
    • Journal Title

      Anal Sci

      Volume: 29(9) Pages: 871-876

    • NAID

      10031196097

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histopathological Evaluation of the Diversity of Cells Susceptible to H5N1 Virulent Avian Influenza Virus2013

    • Author(s)
      H. Ogiwara, F. Yasui, K. Munekata, A. Takagi-Kamiya, T. Munakata, N. Nomura, F. Shibasaki, K. Kuwahara, N. Sakaguchi, Y. Sakoda, H. Kida and M. Kohara
    • Journal Title

      Am J Pathol

      Volume: S0002-9440(13) Pages: 681-0

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Broad-Spectrum Detection of H5 Subtype Influenza A Viruses with a New Fluorescent Immunochromatography System2013

    • Author(s)
      Akira Sakurai, Katsuyoshi Takayama, Namiko Nomura, Tsubasa Munakata, Naoki Yamamotod, Tsuruki Tamura, Jitsuho Yamada, Masako Hashimoto, Kazuhiko Kuwahara, Yoshihiro Sakoda, Yoshihiko Suda, Yukuharu Kobayashi, Nobuo Sakaguchi, Hiroshi Kida, Michinori Kohara, Futoshi Shibasaki
    • Journal Title

      PLoS ONE

      Volume: 8(11)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Isolation of recombinant phage antibodies targeting the hemagglutinin cleavage site of highly pathogenic avian influenza virus2013

    • Author(s)
      Dong J, Sakurai A, Nomura N, Park EY, Shibasaki F, Ueda H
    • Journal Title

      PLoS One

      Volume: 8(4)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 高感度蛍光イムノクロマト法の開発とインフルエンザウイルス検出への応用2013

    • Author(s)
      櫻井 陽 野村奈美子 細川幸生 橋本麻紗子 芝崎 太 原 光彦 関谷 紀貴 田中 理子
    • Journal Title

      東京都福祉保健医療学会誌

      Volume: (2012度版) Pages: 30-31

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protein-based open sandwich immuno-PCR for sensitive detection of small biomarkers.2013

    • Author(s)
      S. Hasan, J. Dong, Y. Hara, Y. Morizane, F. Shibasaki and H. Ueda
    • Journal Title

      Analytical Chemistry

      Volume: 29 Pages: 871-876

    • NAID

      10031196097

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histopathological evaluation of the diversity of cells susceptible to H5N1 virulent avian influenza virus2013

    • Author(s)
      Ogiwara H, Yasui F, Munekata K, Takagi-Kamiya A, Munakata T, Nomura N, Shibasaki F, Kuwahara K, Sakaguchi N, Sakoda Y, Kida H, Kohara M
    • Journal Title

      Am. J. Pathol

      Volume: 184 Issue: 1 Pages: 171-183

    • DOI

      10.1016/j.ajpath.2013.10.004

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Broad-spectrum detection of h5 subtype influenza a viruses with a new fluorescent immunochromatography system2013

    • Author(s)
      Sakurai A, Takayama K, Nomura N, Munakata T, Yamamoto N, Tamura T, Yamada J, Hashimoto M, Kuwahara K, Sakoda Y, Suda Y, Kobayashi Y, Sakaguchi N, Kida H, Kohara M, Shibasaki F
    • Journal Title

      PLoS One

      Volume: 8 Issue: 11 Pages: e76753-e76753

    • DOI

      10.1371/journal.pone.0076753

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a highly sensitive immuno-PCR assay for the measurement of alpha-galactosidase A protein levels in serum and plasma2013

    • Author(s)
      Nakano, S. Morizane, Y. Makisaka, N. Suzuki, T. Togawa, T. Tsukimura, T. Kawashima, I. Sakuraba, H. Shibasaki, F.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 11 Pages: e78588-e78588

    • DOI

      10.1371/journal.pone.0078588

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytokine marker measurement in human neuroblastoma cells with supersensitive and multiplex assay: MUSTag technology.2013

    • Author(s)
      Miyashita R1, Chen L, Morizane Y, Takeshita Y, Fukui H, Ishizaki T, Hatakeyama K, Ohseto K, Shibasaki F, Uchino H.
    • Journal Title

      Acta Neurochir Suppl.

      Volume: 118 Pages: 317-320

    • DOI

      10.1007/978-3-7091-1434-6_62

    • ISBN
      9783709114339, 9783709114346
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Int6/eIF3e silenced HIF2alpha stabilization enhances migration and tube formation of HUVECs via IL-6 and IL-8 signaling2013

    • Author(s)
      Endler, A. Chen, L. Li, Q. Uchida, K. Hashimoto, T. Lu, L. Xu, G. T. Shibasaki, F.
    • Journal Title

      Cytokine

      Volume: 62 Issue: 1 Pages: 115-122

    • DOI

      10.1016/j.cyto.2013.01.021

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Isolation of recombinant phage antibodies targeting the hemagglutinin cleavage site of highly pathogenic avian influenza virus2013

    • Author(s)
      Jinhua Dong, Akira Sakurai, Namiko Nomura, Enoch Y.Park, Futoshi Shibasaki, Hiroshi Ueda
    • Journal Title

      PLoS One

      Volume: 8巻 Issue: 4 Pages: e61158-e61158

    • DOI

      10.1371/journal.pone.0061158

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell-penetrating peptide2013

    • Author(s)
      梶原直樹、芝崎 太
    • Journal Title

      日本薬理学会雑誌

      Volume: 141 Pages: 220-221

    • NAID

      10031165479

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Updated values for molecular diagnosis for highly pathogenic avian influenza virus.2012

    • Author(s)
      Sakurai A, Shibasaki F.
    • Journal Title

      Viruses.

      Volume: 4(8) Issue: 8 Pages: 1235-1257

    • DOI

      10.3390/v4081235

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 新機能抗体開発ハンドブック ~次世代抗体創薬から産業の展開まで~ 第1編 抗体開発技術-基礎第4章 抗原-抗体反応の評価 92012

    • Author(s)
      遠藤典子、芝崎 太
    • Journal Title

      ELISA (Enzyme-Linked ImmunoSorbent Assay), (株式会社エヌ・ティー・エス)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Int6 silencing causes induction of angiogenic factors in neuronal cells via accumulation of hypoxia-inducible factor 2αand decreases br ain damage in rats2012

    • Author(s)
      Miyashita R, Chen L, Oshiro H, Uchino H, Shibasaki F
    • Journal Title

      Neurosci Lett

      Volume: 528(1) Issue: 1 Pages: 83-8

    • DOI

      10.1016/j.neulet.2012.08.033

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Updated Values for Molecular Diagnosis for Highly Pathogenic Avian Influenza Virus.2012

    • Author(s)
      Sakurai A
    • Journal Title

      Viruses

      Volume: 4 Pages: 1235-1257

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Updated Values of Molecular Diagnosis for Highly Pathogenic Avian Influenza Virus.2012

    • Author(s)
      Sakurai A and Shibasaki F
    • Journal Title

      Viruses

      Volume: not determined

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rapid typing of influenza viruses using super high-speed quantitative real-time PCR2011

    • Author(s)
      Sakurai A, Nomura N, Nanba R, Sinkai T, Iwaki T, Obayashi T, Hashimoto K, Hasegawa M, Sakoda Y, Naito A, Morizane Y, Hosaka M, Tsuboi K, Kida H, Kai A, Shibasaki F
    • Journal Title

      J Virol Methods

      Volume: 178(1-2) Pages: 75-81

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] インフルエンザ迅速遺伝子診断法の開発2011

    • Author(s)
      櫻井 陽、南波玲子、野村奈美子、内藤暁宏、森實芳仁、芝崎 太、大林民典、後藤 薫、新開敬行、長谷川道弥、保坂三継、甲斐明美
    • Journal Title

      東京都福祉保健医療学会誌

      Pages: 7-11

    • Related Report
      2013 Final Research Report
  • [Journal Article] Rapid typing of influenza viruses using super high-speed quantitative real-time PCR.2011

    • Author(s)
      Sakurai A, Nomura N, Nanba R, Sinkai T, Iwaki T, Obayashi T, Hashimoto K, Hasegawa M, Sakoda Y, Naito A, Morizane Y, Hosaka M, Tsuboi K, Kida H, Kai A, Shibasaki F
    • Journal Title

      J Virol Methods

      Volume: 178 Pages: 75-81

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] バイオベンチャー企業の知恵と技術2013

    • Author(s)
      芝崎 太
    • Organizer
      東京都立産業技術研究センター「バイオ応用技術フォーラム」
    • Place of Presentation
      東京イノベーションハブ
    • Year and Date
      2013-09-02
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 新規インフルエンザ診断技術の開発2013

    • Author(s)
      櫻井 陽、野村奈美子、細川幸生、橋本麻紗子、芝崎 太
    • Organizer
      Cell Biology Summer Meeting (CBSM) 2013
    • Place of Presentation
      山梨・笛吹市
    • Year and Date
      2013-07-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of New Diagnosis Systems for Detecting Influenza Viruses2013

    • Author(s)
      Shibasaki F, Sakurai A, Nomura N, Hashimoto A, Kohara M, Kuwahara K, and Sakaguchi N
    • Organizer
      2013 TEPIK&APACI International Influenza Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2013-07-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Open the Future Gate for Bio-Medical Partnerships vs"TOBIRA"2013

    • Author(s)
      Shibasaki.F and Koide T
    • Organizer
      The American Chamber of Commerce in Japan (ACCJ)
    • Place of Presentation
      Tokyo
    • Year and Date
      2013-06-28
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 産官学医連携による実用化開発の現状2013

    • Author(s)
      芝崎 太
    • Organizer
      三重大学地方イノベーション学研究科講義
    • Year and Date
      2013-06-25
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation]2013

    • Author(s)
      Shibasaki F
    • Organizer
      Opening Remark : 3^<rd> IGAKUKEN International Symposium
    • Place of Presentation
      Igakuken
    • Year and Date
      2013-02-15
    • Related Report
      2013 Final Research Report
  • [Presentation] インフルエンザウイルスの新規診断法2013

    • Author(s)
      芝崎 太、櫻井 陽、野村奈美子
    • Organizer
      第2回研究フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2013-02-05
    • Related Report
      2013 Final Research Report
  • [Presentation] 開発したH5 インフルエンザ用抗体の特徴2013

    • Author(s)
      芝崎 太、櫻井 陽、野村奈美子
    • Organizer
      1月30日 鹿児島大学共同獣医学部附属越境性動物疾病制御(TAD)研究センターセミナー
    • Place of Presentation
      鹿児島
    • Year and Date
      2013-01-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of new diagnosis systems for detecting influenza viruses2013

    • Author(s)
      Akira Sakurai
    • Organizer
      3^<rd> IGAKUKEN International Symposium on Control of Influenza virus and Hepatitis
    • Place of Presentation
      Tokyo
    • Year and Date
      2013-01-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 高感度蛍光イムノクロマト法の開発とインフルエンザウイルス検出への応用2012

    • Author(s)
      櫻井 陽、野村奈美子、細川幸生、橋本麻紗子、芝崎 太、原 光彦、関谷紀貴、田中理子
    • Organizer
      2012年 第8回東京都福祉保健医療学会
    • Place of Presentation
      東京
    • Year and Date
      2012-12-21
    • Related Report
      2013 Final Research Report
  • [Presentation] バイオマーカーの臨床評価に基づく基盤診断法・機器の開発2012

    • Author(s)
      芝崎 太、櫻井 陽、野村奈美子、遠藤典子
    • Organizer
      日本プロテオーム学会2012年大会
    • Place of Presentation
      東京
    • Year and Date
      2012-07-27
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 高病原性トリインフルエンザウイルスH5N1 亜型における新規侵入経路の発見2012

    • Author(s)
      櫻井 陽 (協力研究者 : 芝崎 太、川島育夫、梶原直樹、野村奈美子、橋本麻紗子)
    • Organizer
      2012年 第60回日本ウイルス学会総会
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] 超高速RT-PCR によるインフルエンザウイルス検出系の確立2012

    • Author(s)
      櫻井 陽
    • Organizer
      第11回CBSM2012
    • Place of Presentation
      伊勢市
    • Related Report
      2013 Final Research Report
  • [Presentation] Sensitive detection of small molecule biomarkers by Open Sandwich Immuno-PCR2012

    • Author(s)
      Sharif Hasan、董 金華、森實 芳仁、芝崎 太、*上田 宏
    • Organizer
      化学工業会 第44回秋季大会
    • Place of Presentation
      仙台
    • Related Report
      2012 Research-status Report
  • [Presentation] 正常血管誘導サイトカイン群の同定と診断・細胞移植療法への応用2011

    • Author(s)
      芝崎 太
    • Organizer
      第3回サイトカイン研究会(招待講演)
    • Place of Presentation
      神戸
    • Related Report
      2011 Research-status Report
  • [Presentation] イムノPCR「MUSTag法」の臨床応用と今後の展望2011

    • Author(s)
      芝崎 太
    • Organizer
      第51回日本臨床化学会年次学術集会 企業シンポジウム(招待講演)
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] バイオマーカー測定による癌の新規診断法開発2011

    • Author(s)
      岩田典子、中野早知栄、森實芳仁、鎌田裕子、芝崎 太
    • Organizer
      Conference of BioSignal and Medicine (CBSM)
    • Place of Presentation
      軽井沢
    • Related Report
      2011 Research-status Report
  • [Presentation] MUSTag法/IMPACTag法の基盤技術の確立と分子標的診断への応用2011

    • Author(s)
      森實芳仁 、中野早知栄、長谷川江里香、岩田典子、細川幸生、早川英毅、内藤暁宏、櫻井 陽、野村奈美子、橋本麻紗子、芝崎 太
    • Organizer
      Conference of BioSignal and Medicine (CBSM)
    • Place of Presentation
      軽井沢
    • Related Report
      2011 Research-status Report
  • [Presentation] Cytokine marker measurement in the human neuroblastoma cells with supersensitive and multiplex assay, MUSTag technology2011

    • Author(s)
      Miyashiata, T, Morizane Y, Iwata F, Shibasaki F, Uchino H
    • Organizer
      Brain Edema 2011
    • Place of Presentation
      神戸
    • Related Report
      2011 Research-status Report
  • [Presentation] evelopment of New Diagnosis Systems for Detecting Influenza Viruses

    • Author(s)
      1. Shibasaki F, Sakurai A, Nomura N, Hashimoto A, Kohara M, Kuwahara K, and Sakaguchi N:
    • Organizer
      TEPIK&APACI International Influenza Symposium
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Development of a highly sensitive immune-PCR measurement of alpha-galactosidase A protein levels in serum and plasma

    • Author(s)
      Shibasaki F, Nakano S, Togawa T, Tsukimura T, Kawashima I, Sakuraba H
    • Organizer
      he 3rd Asian congress for Inherited Metabolic Diseases (ACIMD) & The 55th Annual Meeting of The Japanese Society for Inherited Metabolic Diseases (JSIMD)
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Annual Research Report
  • [Presentation] 新規インフルエンザ診断技術の開発

    • Author(s)
      14. 櫻井 陽、野村奈美子、細川幸生、橋本麻紗子、芝崎 太
    • Organizer
      第12回Conference for BioSignal and Medicine
    • Place of Presentation
      Yamanashi
    • Related Report
      2013 Annual Research Report
  • [Presentation] Diagnostic Values of Modified Immuno-PCR Method (MUSTag) to Differentially Detect alpha-Galactosidase Proteins in A Subset of Fabry Disease Patients.

    • Author(s)
      Futoshi Shibasaki, Sachie Nakano, and Hitoshi Sakuraba
    • Organizer
      第4回国際ライソゾーム病フォーラム
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] バイオマーカーの臨床評価に基づく基盤診断法・機器の開発

    • Author(s)
      芝崎 太、櫻井 陽、野村奈美子、遠藤典子
    • Organizer
      JHUPO
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 産学連携体制を基盤とした次世代の診断法の開発東京バイオマーカー・イノベーション技術研究組合の意義

    • Author(s)
      芝崎 太
    • Organizer
      三重大学大学院 特別講演
    • Place of Presentation
      三重
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 子宮頸がん予防ワクチンの接種効果測定法の検討

    • Author(s)
      遠藤典子、櫻井 陽、細川幸生、野村奈美子、橋本麻紗子、清水達哉、田畑 務、芝崎 太
    • Organizer
      第11回Conference of BioSignal and Medicine (CBSM)
    • Place of Presentation
      伊勢市
    • Related Report
      2012 Research-status Report
  • [Presentation] HIF-2αと新規結合因子CGI-97/SBDSの相互作用解

    • Author(s)
      貞任大地,田島陽一、陳リー、*芝崎 太
    • Organizer
      第11回Conference of BioSignal and Medicine (CBSM)
    • Place of Presentation
      伊勢市
    • Related Report
      2012 Research-status Report
  • [Presentation] 子宮頸がん予防ワクチンの効果測定法開発

    • Author(s)
      遠藤典子、櫻井 陽、細川幸生、野村奈美子、橋本麻紗子、清水達哉、川村眞智子、菅沼明彦、芝崎 太
    • Organizer
      第8回 東京都福祉保健医療学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 高感度蛍光イムノクロマト法の開発とインフルエンザウイルス検出への応用

    • Author(s)
      櫻井 陽、細川幸生、野村奈美子、橋本麻紗子、*芝崎 太
    • Organizer
      第8回 東京都福祉保健医療学会
    • Place of Presentation
      仙台
    • Related Report
      2012 Research-status Report
  • [Presentation] 子宮頸がん予防ワクチンの接種効果測定法の検討

    • Author(s)
      遠藤典子、川村眞智子、菅沼明彦、小林行治、小林薫、安藤義将、芝崎 太
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] HIF-2αと新規結合因子CGI-97/SBDSの相互作用解析

    • Author(s)
      貞任大地,田島陽一、陳リー、芝崎 太
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 高感度多項目測定(MUSTag)法を用いたFabry病中間型診断への応用

    • Author(s)
      中野早知栄、櫻庭 均、芝崎 太
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Book] Biochemical Basis and Therapeutic Implications of Angiogenesis2013

    • Author(s)
      Hideki Hayakawa
    • Total Pages
      532
    • Publisher
      Springer
    • Related Report
      2012 Research-status Report
  • [Book] 新機能抗体開発ハンドブック2012

    • Author(s)
      遠藤典子、芝崎 太
    • Total Pages
      680
    • Publisher
      株式会社 エヌ・ティー・エス
    • Related Report
      2012 Research-status Report
  • [Book] 新機能抗体開発ハンドブック ~次世代抗体創製から産業の展開まで~第1編 抗体開発技術-基礎、第4章 抗原-抗体反応の評価2012

    • Author(s)
      芝崎太、岩田典子
    • Publisher
      (株)エヌ・ティー・エス
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.molmed.jp/index.html

    • Related Report
      2013 Final Research Report
  • [Remarks] (公財)東京都医学総合研究所

    • URL

      http://www.igakuken.or.jp/

    • Related Report
      2013 Annual Research Report
  • [Remarks] ゲノム医科学分野 分子医療プロジェクト

    • URL

      http://www.molmed.jp/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 研究目的

    • URL

      http://www.molmed.jp/projectcorner/project.html

    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] α-ガラクトシダーゼ濃度を測定する方法2012

    • Inventor(s)
      芝崎 太、中野早知栄、櫻庭 均
    • Industrial Property Rights Holder
      芝崎 太、中野早知栄、櫻庭 均
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-10-04
    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] 高病原性トリインフルエンザに対する抗体2012

    • Inventor(s)
      芝崎 太、小原道法、阪口薫雄、桑原一彦
    • Industrial Property Rights Holder
      芝崎 太、小原道法、阪口薫雄、桑原一彦
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-12-10
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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