| Project/Area Number |
23659316
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | University of Toyama |
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Principal Investigator |
KURAISHI Yasushi 富山大学, 大学院医学薬学研究部(薬学), 教授 (80111970)
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| Co-Investigator(Renkei-kenkyūsha) |
ANDOH Tsugunobu 富山大学, 大学院医学薬学研究部(薬学), 准教授 (50333498)
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| Research Collaborator |
HAZA Satomi 富山大学, 大学院医学薬学教育部(薬学), 大学院生
TAKAHASHI Ryohei 富山大学, 大学院医学薬学教育部(薬学), 大学院生
MIZUTA Ayaka 富山大学, 大学院医学薬学教育部(薬学), 大学院生
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 痒み / 鎮痒薬 / バイオマーカー / 血清中因子 / 副腎皮質刺激ホルモン / アトピー性皮膚炎 / 抗アレルギー薬 / 鎮痛薬 / PAR2受容体 / グランザイムA / ACTH |
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| Research Abstract |
We searched useful biomarkers for evaluation of antipruritic agents in serum and plasma, using mouse models for chronic pruritus. Adrenocorticotropic hormone (ACTH) was found to be reduced in the plasma of mice with chronic pruritus, and this decrease was reversed by agents that inhibited itching behaviors. Thus, ACTH may be useful biomarkers for itching and itch-associated stress. Granzyme A and some serum protein, changes of which were revealed by proteomic analysis, are still analyzed as possible pruritus biomarkers.
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