| Project/Area Number |
23659317
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | University of Fukui |
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Principal Investigator |
MURASE Kazuyuki (2012) 福井大学, 大学院・工学研究科, 教授 (40174239)
村瀬 一之 福井大学, 工学(系)研究科(研究院), 教授 (40174289)
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| Co-Investigator(Renkei-kenkyūsha) |
IKEDA Hiroshi 福井大学, 大学院・工学研究科, 教授 (80377473)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 痛覚過敏 / グリア細胞 / 脊髄後角 / 膜電位イメージング / カルシウムイメージング / ATP / 慢性疼痛 / 中枢性感作 / 疼痛 / 共焦点顕微鏡 |
|---|
| Research Abstract |
Signaling pathway for inflammatory pain has been thought to be different from that of neuropathic pain. In order to reveal the pathways, we developed a simultaneous imaging method of membrane potentials and intracellular calcium ions. We dissociated neuronal activities, activities of astrocytes, and activities of micro glia. We revealed that astrocytes contribute to the generation of inflammatory pain and microglia of neuropathic pain
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